Novel Approach to Systematically Characterize Exercise- and Nutrient- responsive genes in Type 2 diabetes and cardiovascular disease

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Accessible data curation and analytics for international-scale citizen science datasets.

Author(s): Murray B, Kerfoot E, Chen L, Deng J, Graham MS, Sudre CH, Molteni E, Canas LS, Antonelli M, Klaser K, Visconti A, Hammers A, Chan AT, Franks PW, Davies R, Wolf J, Spector TD, Steves CJ, Modat M, Ourselin S.
Published in: Sci Data, Issue 8(1), 2021, Page(s) 297, ISSN 2052-4463
Publisher: Springer
DOI: 10.1038/s41597-021-01071-x

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes.

Author(s): Sonia García-Calzón; Sonia García-Calzón; Alexander Perfilyev; Mats Martinell; Monta Ustinova; Sebastian Kalamajski; Paul W. Franks; Karl Bacos; Ilze Elbere; Jussi Pihlajamäki; Petr Volkov; Allan Vaag; Leif Groop; Marlena Maziarz; Janis Klovins; Janis Klovins; Emma Ahlqvist; Charlotte Ling
Published in: Sci Transl Med, Issue 25, 2020, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz1803

Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

Author(s): Deirdre K. Tobias; Jordi Merino; Abrar Ahmad; Catherine Aiken; Jamie L. Benham; Dhanasekaran Bodhini; Amy L. Clark; Kevin Colclough; Rosa Corcoy; Sara J. Cromer; Daisy Duan; Jamie L. Felton; Ellen C. Francis; Pieter Gillard; Véronique Gingras; Romy Gaillard; Eram Haider; Alice Hughes; Jennifer M. Ikle; Laura M. Jacobsen; Anna R. Kahkoska; Jarno L. T. Kettunen; Raymond J. Kreienkamp; Lee-Ling Lim;
Published in: Nat Med, Issue 29(10), 2023, Page(s) 2438-2457, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-023-02502-5

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Author(s): Robert W. Koivula; Robert W. Koivula; Ian M Forgie; Azra Kurbasic; Ana Viñuela; Ana Viñuela; Alison Heggie; Giuseppe N. Giordano; Tue H. Hansen; Michelle Hudson; Anitra D.M. Koopman; Femke Rutters; Maritta Siloaho; Kristine H. Allin; Soren Brage; Soren Brage; Caroline Brorsson; Adem Y. Dawed; Federico De Masi; Christopher J. Groves; Tarja Kokkola; Anubha Mahajan; Mandy H Perry; Simone P. Rauh; M
Published in: Diabetologia, Issue 62, 2019, Page(s) 1601-15, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-4906-1

Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity

Author(s): Harshal A Deshmukh, Anne Lundager Madsen, Ana Viñuela, Christian Theil Have, Niels Grarup, Andrea Tura, Anubha Mahajan, Alison J Heggie, Robert W Koivula, Federico De Masi, Konstantinos K Tsirigos, Allan Linneberg, Thomas Drivsholm, Oluf Pedersen, Thorkild I A Sørensen, Arne Astrup, Anette A P Gjesing, Imre Pavo, Andrew R Wood, Hartmut Ruetten, Angus G Jones, Anitra D M Koopman, Henna Cederberg,
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 106, 2021, Page(s) 80-90, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgaa653

Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover

Author(s): Mi Huang; Melina Claussnitzer; Alham Saadat; Daniel E. Coral; Sebastian Kalamajski; Paul W. Franks
Published in: Diabetologia, Issue 66(7), 2023, Page(s) 1289-1305, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-023-05915-6

Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness.

Author(s): Amra Jujic; Peter M. Nilsson; Naeimeh Atabaki-Pasdar; Anna Dieden; Tiinamaija Tuomi; Paul W. Franks; Paul W. Franks; Jens J. Holst; Signe S. Torekov; Susana Ravassa; Javier Díez; Margaretha Persson; Emma Ahlqvist; Olle Melander; Maria F. Gomez; Leif Groop; Leif Groop; Martin Magnusson
Published in: Diabetes Care, Issue 44(1), 2021, Page(s) 224-230, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc20-1318

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study.

Author(s): Robert W. Koivula; Robert W. Koivula; Naeimeh Atabaki-Pasdar; Giuseppe N. Giordano; Thomas E. White; Jerzy Adamski; Jerzy Adamski; Jimmy D. Bell; Joline W.J. Beulens; Soren Brage; Soren Brage; Søren Brunak; Søren Brunak; Federico De Masi; Federico De Masi; Emmanouil T. Dermitzakis; Emmanouil T. Dermitzakis; Ian M Forgie; Gary Frost; Torben Hansen; Torben Hansen; Tue H. Hansen; Andrew T. Hattersl
Published in: Diabetologia, Issue 63(4), 2020, Page(s) 744-756, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-05083-6

Validity of continuous glucose monitoring for categorizing glycemic responses to diet: implications for use in personalized nutrition

Author(s): Jordi Merino; Inbar Linenberg; Kate M Bermingham; Sajaysurya Ganesh; Elco Bakker; Linda M Delahanty; Andrew T Chan; Joan Capdevila Pujol; Jonathan Wolf; Haya Al Khatib; Paul W Franks; Tim D Spector; Jose M Ordovas; Sarah E Berry; Ana M Valdes
Published in: Am J Clin Nutr, Issue 115(6), 2022, Page(s) 1569-1576, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqac026

Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Author(s): Wendy K. Chung; Karel A. Erion; Jose C. Florez; Andrew T. Hattersley; Marie-France Hivert; Christine G. Lee; Mark I. McCarthy; John J. Nolan; Jill M. Norris; Ewan R. Pearson; Louis H. Philipson; Allison T. McElvaine; William T. Cefalu; Stephen S. Rich; Paul W. Franks
Published in: Diabetes Care, Issue 32, 2020, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dci20-0022

Human Genetic Variation at rs10071329 Correlates with Adiposity-related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function

Author(s): Huang M, Prasad RB, Coral DE, Hjort L, Minja DTR, Mulder H, Franks PW, Kalamajski S.
Published in: Diabetes, Issue Jan 8, 2024, Page(s) db230531, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db23-0531

Association of Established Blood Pressure Loci With 10-Year Change in Blood Pressure and Their Ability to Predict Incident Hypertension

Author(s): Poveda A, Atabaki-Pasdar N, Ahmad S, Hallmans G, Renström F, Franks PW
Published in: J Am Heart Assoc, Issue 9(16), 2020, Page(s) e14513, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.119.014513

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.

Author(s): Francesco Asnicar; Sarah Berry; Ana M. Valdes; Ana M. Valdes; Long H. Nguyen; Gianmarco Piccinno; David A. Drew; Emily R Leeming; Rachel J. Gibson; Caroline I. Le Roy; Haya Al Khatib; Lucy Francis; Mohsen Mazidi; Olatz Mompeo; Mireia Valles-Colomer; Adrian Tett; Francesco Beghini; Leonard Dubois; Davide Bazzani; Andrew Maltez Thomas; Chloe Mirzayi; Asya Khleborodova; Sehyun Oh; Rachel Hine; Christ
Published in: The Lancet Microbe, Vol 2, Iss 11, Pp e565-e566 (2021), Issue 30, 2021, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-020-01183-8

A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19

Author(s): Carl Bonander; Debora Stranges; Johanna Gustavsson; Matilda Almgren; Malin Inghammar; Mahnaz Moghaddassi; Anton Nilsson; Joan Capdevila Pujol; Claire Steves; Paul W Franks; Maria F Gomez; Tove Fall; Jonas Björk; Andrew T Chan; Sébastien Ourselin; Tim D Spector; Jonathan Wolf; Beatrice Kennedy; Hugo Fitipaldi; Ulf Hammar; Marlena Maziarz; Neli Tsereteli; Nikolay Oskolkov; Georgios Varotsis; Lampr
Published in: Eur J Publ Health, Issue 32(5), 2022, Page(s) 799-806, ISSN 1464-360X
Publisher: Oxford Academic
DOI: 10.1093/eurpub/ckac101

Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression.

Author(s): MetGen Plus Consortium; Kalamajski, Sebastian; Huang, Mi; Dalla-Riva, Jonathan; Keller, Maria; Dawed, Adem Y.; Hansson, Ola; Pearson, Ewan R.; Mulder, Hindrik; Franks, Paul W.
Published in: Hum Mol Genet, Issue 31(4), 2022, Page(s) 491-498, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddab266

App-based COVID-19 surveillance and prediction: The COVID Symptom Study Sweden

Author(s): Beatrice Kennedy; Hugo Fitipaldi; Ulf Hammar; Marlena Maziarz; Neli Tsereteli; Nikolay Oskolkov; Georgios Varotsis; Camilla A Franks; Lampros Spiliopoulos; Hans-Olov Adami; Jonas Björk; Stefan Engblom; Katja Fall; Anna Grimby-Ekman; Jan-Eric Litton; Mats Martinell; Anna Oudin; Anna Oudin; Torbjörn Sjöström; Toomas Timpka; Carole H. Sudre; Mark Graham; Julien Lavigne du Cadet; Andrew T. Chan; R
Published in: Nat Commun, Issue 13 (1), 2021, Page(s) 2110, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29608-7

Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits

Author(s): Poveda, Alaitz; Pomares-Millan, Hugo; Chen, Yan; Kurbasic, Azra; Patel, Chirag J.; Renström, Frida; Hallmans, Göran; Johansson, Ingegerd; Franks, Paul W.
Published in: Scientific Reports, Issue 12(1), 2022, Page(s) 4088, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-08050-1

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration.

Author(s): Henry R, Wilman; Constantinos A, Parisinos; Naeimeh, Atabaki-Pasdar; Matt, Kelly; E Louise, Thomas; Stefan, Neubauer; Anubha, Mahajan; Aroon D, Hingorani; Riyaz S, Patel; Harry, Hemingway; Paul W, Franks; Jimmy D, Bell; Rajarshi, Banerjee; Brandon, Whitcher
Published in: Journal of Hepatology, Issue 25, 2019, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2019.05.032

GWAS in people of Middle Eastern descent reveals a locus protective of kidney function—a cross-sectional study

Author(s): Siham A. Mohamed; Juan Fernadez-Tajes; Paul W. Franks; Louise Bennet
Published in: BMC Medicine, Issue 20(1), 2022, Page(s) 76, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-022-02267-7

Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research.

Author(s): Franks PW, Pomares-Millan H.
Published in: Diabetologia, Issue 63(12), 2020, Page(s) 2521-2532, ISSN 1432-0428
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05246-w

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts.

Author(s): Atabaki-Pasdar N, Ohlsson M, Viñuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, Forgie IM, McDonald TJ, Rutters F, Cederberg H, Chabanova E, Dale M, Masi F, Thomas CE, Allin KH, Hansen TH, Heggie A, Hong MG, Elders PJM, Kennedy G, Kokkola T, Pedersen HK, Mahajan A, McEvoy D, Pattou F, Raverdy V, Häu
Published in: PLoS Med, 2020, ISSN 1549-1277
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1003149

Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study.

Author(s): Bermingham KM, Linenberg I, Hall WL, Kadé K, Franks PW, Davies R, Wolf J, Hadjigeorgiou G, Asnicar F, Segata N, Manson JE, Newson LR, Delahanty LM, Ordovas JM, Chan AT, Spector TD, Valdes AM, Berry SE.
Published in: EBioMedicine, Issue 85, 2022, Page(s) 104303, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104303

A saturated map of common genetic variants associated with human height

Author(s): Yengo, Loïc; Vedantam, Sailaja; Marouli, Eirini; Sidorenko, Julia; Bartell, Eric; Sakaue, Saori; Graff, Marielisa; Eliasen, Anders U; Jiang, Yunxuan; Raghavan, Sridharan; Miao, Jenkai; Arias, Joshua D; Graham, Sarah E; Mukamel, Ronen E; Spracklen, Cassandra N; Yin, Xianyong; Chen, Shyh-Huei; Ferreira, Teresa; Highland, Heather H; Ji, Yingjie; Karaderi, Tugce; Lin, Kuang; Lüll, Kreete; Malden, De
Published in: Nature, Issue 610(7933), 2022, Page(s) 704-712, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05275-y

Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women.

Author(s): Mutie PM, Pomares-Milan H, Atabaki-Pasdar N, Coral D, Fitipaldi H, Tsereteli N, Tajes JF, Franks PW, Giordano GN.
Published in: Diabetologia, Issue 66(2), 2023, Page(s) 321-335, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-022-05811-5

Ethnic, gender and other sociodemographic biases in genome-wide association studies for the most burdensome non-communicable diseases: 2005–2022

Author(s): Hugo, Fitipaldi; Paul W, Franks
Published in: Hum Mol Genet, Issue 32(3), 2023, Page(s) 520-532, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddac245

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study.

Author(s): Valborg Gudmundsdottir; Helle Krogh Pedersen; Gianluca Mazzoni; Gianluca Mazzoni; Kristine H. Allin; Kristine H. Allin; Anna Artati; Joline W.J. Beulens; Joline W.J. Beulens; Karina Banasik; Caroline Brorsson; Henna Cederberg; Elizaveta Chabanova; Federico De Masi; Petra J. M. Elders; Ian M Forgie; Giuseppe N. Giordano; Harald Grallert; Ramneek Gupta; Ramneek Gupta; Mark Haid; Torben Hansen; Torbe
Published in: Genome Med, Issue 12(1), 2020, Page(s) 109, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-020-00806-6

Human postprandial responses to food and potential for precision nutrition

Author(s): Berry SE, Valdes AM, Drew DA, Asnicar F, Mazidi M, Wolf J, Capdevila J, Hadjigeorgiou G, Davies R, Al Khatib H, Bonnett C, Ganesh S, Bakker E, Hart D, Mangino M, Merino J, Linenberg I, Wyatt P, Ordovas JM, Gardner CD, Delahanty LM, Chan AT, Segata N, Franks PW, Spector TD.
Published in: Nat Med, 2020, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-020-0934-0

How people wake up is associated with previous night's sleep together with physical activity and food intake

Author(s): Vallat R, Berry SE, Tsereteli N, Capdevila J, Khatib HA, Valdes AM, Delahanty LM, Drew DA, Chan AT, Wolf J, Franks PW, Spector TD, Walker MP.
Published in: Nat Commun, Issue 13(1), 2022, Page(s) 7116, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34503-2

Characterisation of Fasting and Postprandial NMR Metabolites: Insights from the ZOE PREDICT 1 Study.

Author(s): Bermingham KM, Mazidi M, Franks PW, Maher T, Valdes AM, Linenberg I, Wolf J, Hadjigeorgiou G, Spector TD, Menni C, Ordovas JM, Berry SE, Hall WL.
Published in: Nutrients, Issue 15(11), 2023, Page(s) 2638, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15112638

Snack quality and snack timing are associated with cardiometabolic blood markers: the ZOE PREDICT study.

Author(s): Bermingham KM, May A, Asnicar F, Capdevila J, Leeming ER, Franks PW, Valdes AM, Wolf J, Hadjigeorgiou G, Delahanty LM, Segata N, Spector TD, Berry SE.
Published in: Eur J Nutr., Issue 63(1), 2024, Page(s) 121-133, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-023-03241-6

Identification of a weight loss-associated causal eQTL in<i>MTIF3</i>and the effects of<i>MTIF3</i>deficiency on human adipocyte function

Author(s): Mi Huang; Daniel Coral; Hamidreza Ardalani; Peter Spegel; Alham Saadat; Melina Claussnitzer; Hindrik Mulder; Paul W Franks; Sebastian Kalamajski
Published in: eLife, Issue 12, 2023, Page(s) e84168, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.84168

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.

Author(s): Carl Herdenberg; Pascal M. Mutie; Ola Billing; Ahmad Sharmi Abdullah; Rona J. Strawbridge; Rona J. Strawbridge; Ingrid Dahlman; Simon Tuck; Camilla Holmlund; Peter Arner; Roger Henriksson; Paul W. Franks; Håkan Hedman
Published in: Commun Biol, Issue 4(1), 2021, Page(s) 90, ISSN 2399-3642
Publisher: Nature Portfolio
DOI: 10.1038/s42003-020-01613-w

ADA/EASD Precision Medicine in Diabetes Initiative: An International Perspective and Future Vision for Precision Medicine in Diabetes

Author(s): John J. Nolan; Anna R. Kahkoska; Zhila Semnani-Azad; Marie-France Hivert; Linong Ji; Viswanathan Mohan; Robert H. Eckel; Louis H. Philipson; Stephen S. Rich; Chandra Gruber; Paul W. Franks
Published in: Diabetes Care, Issue 45(2), 2022, Page(s) 261-266, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-2216

A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

Author(s): Daniel E. Coral; Juan Fernandez-Tajes; Neli Tsereteli; Hugo Pomares-Millan; Hugo Fitipaldi; Pascal M. Mutie; Naeimeh Atabaki-Pasdar; Sebastian Kalamajski; Alaitz Poveda; Tyne W. Miller-Fleming; Xue Zhong; Giuseppe N. Giordano; Ewan R. Pearson; Nancy J. Cox; Paul W. Franks
Published in: Nat Metab, Issue 5(2), 2023, Page(s) 237-247, ISSN 2522-5812
Publisher: Nature Portfolio
DOI: 10.1038/s42255-022-00731-5

Established BMI-associated genetic variants and their prospective associations with BMI and other cardiometabolic traits: the GLACIER Study

Author(s): S Ahmad, A Poveda, D Shungin, I Barroso, G Hallmans, F Renström, P W Franks
Published in: International Journal of Obesity, Issue 40/9, 2016, Page(s) 1346-1352, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/ijo.2016.72

Lifestyle precision medicine: the next generation in type 2 diabetes prevention?

Author(s): Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks
Published in: BMC Medicine, Issue 15/1, 2017, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-017-0938-x

Bicycling to Work and Primordial Prevention of Cardiovascular Risk: A Cohort Study Among Swedish Men and Women

Author(s): Anders Grøntved, Robert W. Koivula, Ingegerd Johansson, Patrik Wennberg, Lars Østergaard, Göran Hallmans, Frida Renström, Paul W. Franks
Published in: Journal of the American Heart Association, Issue 5/11, 2016, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/JAHA.116.004413

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Author(s): Laura J. Corbin, Vanessa Y. Tan, David A. Hughes, Kaitlin H. Wade, Dirk S. Paul, Katherine E. Tansey, Frances Butcher, Frank Dudbridge, Joanna M. Howson, Momodou W. Jallow, Catherine John, Nathalie Kingston, Cecilia M. Lindgren, Michael O’Donavan, Stephen O’Rahilly, Michael J. Owen, Colin N. A. Palmer, Ewan R. Pearson, Robert A. Scott, David A. van Heel, John Whittaker, Tim Frayling, Martin D.
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03109-y

A Global Overview of Precision Medicine in Type 2 Diabetes

Author(s): Hugo Fitipaldi, Mark I. McCarthy, Jose C. Florez, Paul W. Franks
Published in: Diabetes, Issue 67/10, 2018, Page(s) 1911-1922, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi17-0045

The heritable basis of gene–environment interactions in cardiometabolic traits

Author(s): Alaitz Poveda, Yan Chen, Anders Brändström, Elisabeth Engberg, Göran Hallmans, Ingegerd Johansson, Frida Renström, Azra Kurbasic, Paul W. Franks
Published in: Diabetologia, Issue 60/3, 2017, Page(s) 442-452, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-016-4184-0

The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden: the GLACIER Study

Author(s): Yan Chen, Angela C. Estampador, Maria Keller, Alaitz Poveda, Jonathan Dalla-Riva, Ingegerd Johansson, Frida Renström, Azra Kurbasic, Paul W. Franks, Tibor V. Varga
Published in: International Journal of Obesity, 2018, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-018-0112-3

Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?

Author(s): Paul W Franks, Alaitz Poveda
Published in: Diabetologia, Issue 60/5, 2017, Page(s) 784-792, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4207-5

Exposing the exposures responsible for type 2 diabetes and obesity

Author(s): P. W. Franks, M. I. McCarthy
Published in: Science, Issue 354/6308, 2016, Page(s) 69-73, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaf5094

Causal inference in obesity research

Author(s): P. W. Franks, N. Atabaki-Pasdar
Published in: Journal of Internal Medicine, Issue 281/3, 2017, Page(s) 222-232, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12577

Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults

Author(s): Tibor V. Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, George Hindy, Stefan Gustafsson, Jian’an Luan, Dmitry Shungin, Yan Chen, Christina-Alexandra Schulz, Peter M. Nilsson, Göran Hallmans, Inês Barroso, Panos Deloukas, Claudia Langenberg, Robert A. Scott, Nicholas J. Wareham, Lars Lind, Erik Ingelsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W. Franks
Published in: International Journal of Epidemiology, 2017, Page(s) dyw245, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyw245

Statistical power considerations in genotype-based recall randomized controlled trials

Author(s): Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Dmitry Shungin, Azra Kurbasic, Erik Ingelsson, Ewan R. Pearson, Ashfaq Ali, Paul W. Franks
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep37307

Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

Author(s): Dmitry Shungin, Wei Q. Deng, Tibor V. Varga, Jian'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P. Morris, Nita G. Forouhi, Cecilia Lindgren, Patrik K. E. Magnusson, Nancy L. Pedersen, Göran Hallmans, Audrey Y. Chu, Anne E. Justice, Mariaelisa Graff, Thomas W. Winkler, Lynda M. Rose, Claudia Langenberg, L. Adrienne Cupples, Paul M. Ridker, Nicholas J. Wareham, Ken K. Ong, Ruth J. F. Loos, Dan
Published in: PLOS Genetics, Issue 13/6, 2017, Page(s) e1006812, ISSN 1553-7404
Publisher: PLoS Genetics
DOI: 10.1371/journal.pgen.1006812

Genotype-Based Recall Studies in Complex Cardiometabolic Traits

Author(s): Paul W. Franks, Nicholas J. Timpson
Published in: Circulation: Genomic and Precision Medicine, Issue 11/8, 2018, ISSN 2574-8300
Publisher: American Heart Association, Inc
DOI: 10.1161/CIRCGEN.118.001947

Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring.

Author(s): Josefine Jönsson; Kristina M Renault; Sonia García-Calzón; Alexander Perfilyev; Angela C. Estampador; Kirsten Nørgaard; Mads Vendelbo Lind; Allan Vaag; Line Hjort; Kim F. Michaelsen; Emma Malchau Carlsen; Emma Malchau Carlsen; Paul W. Franks; Charlotte Ling
Published in: Diabetes, Issue 70(4), 2021, Page(s) 854-866, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-0487

Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality

Author(s): Hugo Pomares-Millan; Alaitz Poveda; Naemieh Atabaki-Pasdar; Ingegerd Johansson; Jonas Björk; Mattias Ohlsson; Giuseppe N. Giordano; Paul W. Franks
Published in: Nutrients, Issue 14(15), 2022, Page(s) 3171, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14153171

Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions.

Author(s): Tsereteli N, Vallat R, Fernandez-Tajes J, Delahanty LM, Ordovas JM, Drew DA, Valdes AM, Segata N, Chan AT, Wolf J, Berry SE, Walker MP, Spector TD, Franks PW
Published in: Diabetologi, Issue 65(2), 2022, Page(s) 356-365, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-021-05608-y

Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app.

Author(s): Louca P, Murray B, Klaser K, Graham MS, Mazidi M, Leeming ER, Thompson E, Bowyer R, Drew DA, Nguyen LH, Merino J, Gomez M, Mompeo O, Costeira R, Sudre CH, Gibson R, Steves CJ, Wolf J, Franks PW, Ourselin S, Chan AT, Berry SE, Valdes AM, Calder PC, Spector TD, Menni C.
Published in: BMJ Nutr Prev Health, Issue 4(1), 2021, Page(s) 149-157, ISSN 2516-5542
Publisher: BMJ
DOI: 10.1136/bmjnph-2021-000250

An investigation of causal relationships between prediabetes and vascular complications.

Author(s): Mutie PM, Pomares-Millan H, Atabaki-Pasdar N, Jordan N, Adams R, Daly NL, Tajes JF, Giordano GN, Franks PW.
Published in: Nat Commun, Issue 11(1), 2020, Page(s) 4592, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18386-9

Postprandial glycaemic dips predict appetite and energy intake in healthy individuals

Author(s): Patrick Wyatt; Sarah Berry; Graham Finlayson; Ruairi O'Driscoll; George Hadjigeorgiou; David A. Drew; Haya Al Khatib; Long H. Nguyen; Inbar Linenberg; Andrew T. Chan; Tim D. Spector; Paul W. Franks; Jonathan Wolf; John E. Blundell; Ana M. Valdes; Ana M. Valdes; Ana M. Valdes
Published in: 2522-5812, Issue 3(4), 2021, Page(s) 523-529, ISSN 2522-5812
Publisher: Springer
DOI: 10.1038/s42255-021-00383-x

Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort

Author(s): Bermingham KM, Stensrud S, Asnicar F, Valdes AM, Franks PW, Wolf J, Hadjigeorgiou G, Davies R, Spector TD, Segata N, Berry SE, Hall WL
Published in: Eur J Nutr, Issue 62(8), 2023, Page(s) 3135-3147, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-023-03204-x

Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors

Author(s): Merino, Jordi; Jablonski, Kathleen A; Mercader, Josep M; Kahn, Steven E; Chen, Ling; Harden, Maegan; Delahanty, Linda M; Araneta, Maria Rosario G; Walford, Geoffrey A; Jacobs, Suzanne BR; Ibebuogu, Uzoma N; Franks, Paul W; Knowler, William C; Florez, Jose C; Bray, George A; Gadde, Kishore; Chatellier, Annie; Arceneaux, Jennifer; Dragg, Amber; Duncan, Crystal; Greenway, Frank L; Hsia, Daniel; Levy,
Published in: Diabetes, Issue 69(1), 2020, Page(s) 112-120, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db19-0097

Estimating the Direct Effect between Dietary Macronutrients and Cardiometabolic Disease, Accounting for Mediation by Adiposity and Physical Activity.

Author(s): Pomares-Millan, Hugo; Atabaki-Pasdar, Naeimeh; Coral, Daniel; Johansson, Ingegerd; Giordano, Giuseppe N.; Franks, Paul W.
Published in: Nutrients, Issue 14(6), 2022, Page(s) 1218, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14061218

Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study.

Author(s): Francesco Zaccardi; Paul W. Franks; Paul W. Franks; Frank Dudbridge; Melanie J. Davies; Melanie J. Davies; Kamlesh Khunti; Thomas Yates; Thomas Yates
Published in: Eur Soc Cardiol, Issue 28, 2021, Page(s) 704-712, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1177/2047487319885041

Optimizing Exposome-wide Assessments in Cardiometabolic Risk

Author(s): Pomares-Millan, Hugo
Published in: ISSN: 1652-8220, Issue 1, 2022
Publisher: Lund University, Faculty of Medicine

Socioeconomic Disparities Across the Spectrum of Genetic Burden in Type 2 Diabetes and Obesity Risk

Author(s): Paul W. Franks
Published in: Diabetes Care, Issue 46(5), 2023, Page(s) 916-917, ISSN 0149-5992
Publisher: ADA
DOI: 10.2337/dci22-0066

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