Dissecting the role of the ubiquitin proteasome system in the pathogenesis and therapy of B-cell malignancies

Project Information

BCM-UPS

Grant agreement ID: 682473

DOI

10.3030/682473

Project closed

EC signature date 1 July 2016

Start date 1 September 2016

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 973 255,00

EU contribution

€ 1 973 255,00

Coordinated by

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

MCT1 is a predictive marker for lenalidomide maintenance therapy in multiple myeloma

Author(s): Jacob Stroh, Anja Seckinger, Michael Heider, Martina Rudelius, Ruth Eichner, Markus Schick, Jolanta Slawska, Martina Emde-Rajaratnam, Hans Salwender, Uta Bertsch, Hartmut Goldschmidt, Katja Weisel, Christof Scheid, Ulrich Keller, Dirk Hose, Florian Bassermann
Published in: Blood Advances, Issue 24739537, 2022, ISSN 2473-9537
Publisher: Elsevier
DOI: 10.1182/bloodadvances.2021005532

RIG-I activation is critical for responsiveness to checkpoint blockade

Author(s): Simon Heidegger, Alexander Wintges, Florian Stritzke, Sarah Bek, Katja Steiger, Paul-Albert Koenig, Sascha Göttert, Thomas Engleitner, Rupert Öllinger, Tatiana Nedelko, Julius C. Fischer, Vladimir Makarov, Christof Winter, Roland Rad, Marcel R.M. van den Brink, Jürgen Ruland, Florian Bassermann, Timothy A. Chan, Tobias Haas, Hendrik Poeck
Published in: Science Immunology, Issue 4/39, 2019, Page(s) eaau8943, ISSN 2470-9468
Publisher: Science Immunology
DOI: 10.1126/sciimmunol.aau8943

Multiple Myeloma: Molecular Pathogenesis and Disease Evolution

Author(s): Michael Heider, Katharina Nickel, Marion Högner, Florian Bassermann
Published in: Oncology Research and Treatment, 2021, ISSN 2296-5270
Publisher: S. Karger AG
DOI: 10.1159/000520312

SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma

Author(s): Guus J J E Heynen, Francis Baumgartner, Michael Heider, Upayan Patra, Maximilian Holz, Jan Braune, Melanie Kaiser, Isabell Schäffer, Stefanos A Bamopoulos, Evelyn Ramberger, Arunima Murgai, Yuen Lam Dora Ng, Uta Margareta Demel, Dominik Laue, Sven Liebig, Josefine Krüger, Martin Janz, Axel Nogai, Markus Schick, Philipp Mertins, Stefan Müller, Florian Bassermann, Jan Krönke, Ulrich Keller, Matt
Published in: Blood Advances, 2022, ISSN 2473-9529
Publisher: Elsevier
DOI: 10.1182/bloodadvances.2022007875

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

Author(s): Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S. P. Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffe
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18372-1

FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis

Author(s): Peng Xu, Daniel C. Scott, Beisi Xu, Yu Yao, Ruopeng Feng, Li Cheng, Kalin Mayberry, Yong-Dong Wang, Wenjian Bi, Lance E. Palmer, Moeko T. King, Hong Wang, Yuxin Li, Yiping Fan, Arno F. Alpi, Chunliang Li, Junmin Peng, James Papizan, Shondra M. Pruett-Miller, Ria Spallek, Florian Bassermann, Yong Cheng, Brenda A. Schulman, Mitchell J. Weiss
Published in: Blood, Issue 137/2, 2021, Page(s) 155-167, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020007809

Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival

Author(s): Michael Dietachmayr, Abirami Rathakrishnan, Oleksandra Karpiuk, Felix von Zweydorf, Thomas Engleitner, Vanesa Fernández-Sáiz, Petra Schenk, Marius Ueffing, Roland Rad, Martin Eilers, Christian Johannes Gloeckner, Katharina Clemm von Hohenberg, Florian Bassermann
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15059-5

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma

Author(s): Michael Heider, Ruth Eichner, Jacob Stroh, Volker Morath, Anna Kuisl, Jana Zecha, Jannis Lawatscheck, Kheewoong Baek, Anne-Kathrin Garz, Martina Rudelius, Friedrich-Christian Deuschle, Ulrich Keller, Simone Lemeer, Mareike Verbeek, Katharina S. Götze, Arne Skerra, Wolfgang A. Weber, Johannes Buchner, Brenda A. Schulman, Bernhard Kuster, Vanesa Fernández-Sáiz, Florian Bassermann
Published in: Molecular Cell, Issue 81/6, 2021, Page(s) 1170-1186.e10, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.12.046

Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling

Author(s): Jana Zecha, Wassim Gabriel, Ria Spallek, Yun-Chien Chang, Julia Mergner, Mathias Wilhelm, Florian Bassermann, Bernhard Kuster
Published in: nature communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27639-0

The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma

Author(s): Carmen Paulmann, Ria Spallek, Oleksandra Karpiuk, Michael Heider, Isabell Schäffer, Jana Zecha, Susan Klaeger, Michaela Walzik, Rupert Öllinger, Thomas Engleitner, Matthias Wirth , Ulrich Keller, Jan Krönke, Martina Rudelius, Susanne Kossatz, Roland Rad, Bernhard Kuster, Florian Bassermann
Published in: The EMBO Journal, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022110871

Tumor cell‐intrinsic RIG‐I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice

Author(s): Hendrik Poeck, Alexander Wintges, Sarah Dahl, Florian Bassermann, Tobias Haas, Simon Heidegger
Published in: European Journal of Immunology, 2018, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202049158

Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia

Author(s): Irina A. Kerle; Ludwig Jägerhuber; Ramona Secci; Nicole Pfarr; Philipp Blüm; Romina Roesch; Katharina S. Götze; Wilko Weichert; Florian Bassermann; Jürgen Ruland; Christof Winter
Published in: Cancers, Issue 2, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061371

The target landscape of clinical kinase drugs

Author(s): Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter, Huichao Qiao, Dominic Helm, Heiner Koch, Melanie Schoof, Giulia Canevari, Elena Casale, Stefania Re Depaolini, Annette Feuchtinger, Zhixiang Wu, Tobias Schmidt, Lars Rueckert, Wilhelm Becker, Jan Huenges, Anne
Published in: Science, Issue 358/6367, 2017, Page(s) eaan4368, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aan4368

IKZF1 expression is a prognostic marker in newly diagnosed standard-risk multiple myeloma treated with lenalidomide and intensive chemotherapy: a study of the German Myeloma Study Group (DSMM)

Author(s): J Krönke, F Kuchenbauer, M Kull, V Teleanu, L Bullinger, D Bunjes, A Greiner, S Kolmus, S Köpff, M Schreder, L-O Mügge, C Straka, M Engelhardt, H Döhner, H Einsele, F Bassermann, R Bargou, S Knop, C Langer
Published in: Leukemia, Issue 31/6, 2017, Page(s) 1363-1367, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2016.384

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration

Author(s): Ella Fung, Carmen Richter, Hong‐Bin Yang, Isabell Schäffer, Roman Fischer, Benedikt M Kessler, Florian Bassermann, Vincenzo D'Angiolella
Published in: EMBO reports, Issue 19/3, 2018, Page(s) e44799, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201744799

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis

Author(s): Catharina Wenk, Anne-Kathrin Garz, Sonja Grath, Christina Huberle, Denis Witham, Marie Weickert, Roberto Malinverni, Julia Niggemeyer, Michèle Kyncl, Judith Hecker, Charlotta Pagel, Christopher B. Mulholland, Catharina Müller-Thomas, Heinrich Leonhardt, Florian Bassermann, Robert A. J. Oostendorp, Klaus H. Metzeler, Marcus Buschbeck, Katharina S. Götze
Published in: Blood Advances, Issue 2/23, 2018, Page(s) 3447-3461, ISSN 2473-9529
Publisher: Blood Advances
DOI: 10.1182/bloodadvances.2018022053

CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease

Author(s): Judith S. Hecker, Luise Hartmann, Jennifer Rivière, Michèle C. Buck, Mark van der Garde, Maja Rothenberg-Thurley, Luise Fischer, Susann Winter, Bianka Ksienzyk, Frank Ziemann, Maria Solovey, Martina Rauner, Elena Tsourdi, Katja Sockel, Marie Schneider, Anne S. Kubasch, Martin Nolde, Dominikus Hausmann, Alexander C. Paulus, Jörg Lützner, Andreas Roth, Florian Bassermann, Kar
Published in: Blood, 2021, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020010163

MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF

Author(s): Xin Wang, Uris Ros, Deepti Agrawal, Eva C Keller, Julia Slotta-Huspenina, Veronika Dill, Bo Shen, Run Shi, Tobias Herold, Claus Belka, Ritu Mishra, Florian Bassermann, Ana J Garcia-Saez, Philipp J Jost
Published in: Cell Death & Differentiation, Issue 13509047, 2021, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-021-00811-1

Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300

Author(s): Franziska Hettler, Christina Schreck, Sandra Romero Marquez, Thomas Engleitner, Baiba Vilne, Theresa Landspersky, Heike Weidner, Renate Hausinger, Ritu Mishra, Rupert Oellinger, Martina Rauner, Ronald Naumann, Christian Peschel, Florian Bassermann, Roland Rad, Rouzanna Istvanffy, Robert A J Oostendorp
Published in: Haematologica, Issue 03906078, 2022, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.280760

Comprehensive characterization of central BCL-2 family members in aberrant eosinophils and their impact on therapeutic strategies

Author(s): Timo O Odinius, Lars Buschhorn, Celina Wagner, Richard T Hauch, Veronika Dill, Marta Dechant, Michele C Buck, Khalid Shoumariyeh, Philipp Moog, Juliana Schwaab, Andreas Reiter, Knut Brockow, Katharina Götze, Florian Bassermann, Ulrike Höckendorf, Caterina Branca, Philipp J Jost, Stefanie Jilg
Published in: Journal of Cancer Research and Clinical Oncology, 2021, ISSN 0171-5216
Publisher: Springer Verlag
DOI: 10.1007/s00432-021-03827-9

Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease

Author(s): Oliver Hartmann, Michaela Reissland, Carina R. Maier, Thomas Fischer, Cristian Prieto-Garcia, Apoorva Baluapuri, Jessica Schwarz, Werner Schmitz, Martin Garrido-Rodriguez, Nikolett Pahor, Clare C. Davies, Florian Bassermann, Amir Orian, Elmar Wolf, Almut Schulze, Marco A. Calzado, Mathias T. Rosenfeldt, Markus E. Diefenbacher
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, ISSN 2296-634X
Publisher: Front Cell Dev Diol
DOI: 10.3389/fcell.2021.641618

Book chapters (1)

Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma

Author(s): Ruth Eichner, Vanesa Fernández-Sáiz, Bianca-Sabrina Targosz, Florian Bassermann
Published in: International Review of Cell and Molecular Biology volume 343, Issue 343, 2019, Page(s) 219-297, ISBN 9780-128167038
Publisher: Elsevier
DOI: 10.1016/bs.ircmb.2018.06.001