Objective
The impact of insults to the developing brain upon cognition and behaviour has far-reaching consequences for the child, their family, education and health care systems, and government expenditure. Many variables (illness, environmental) contribute to different outcomes following similar insults, and they exert their influence via the child’s developing brain. Predicting which child will recover from early brain insult and identifying those at risk of poor outcome represents a major challenge, with significant health economic implications. An unexplored question is whether direct measurement of the structure and function of the developing brain can improve our ability to predict outcomes in the long-term. Thus, PROBIt aims to assess the utility of brain imaging biomarkers to predict individual neuropsychological and neurobehavioural outcomes following paediatric brain injury, and to identify those factors that combine optimally to classify outcomes. The proposal adopts an unorthodox approach of combining heterogeneous injury groups to explore the structural and functional consequences of perturbing developing brain networks. PROBIt integrates data from clinically relevant paediatric cognitive and behavioural assessment, neuroimaging and computational modelling in large cohorts of children with brain insults. Multivariate pattern analysis will be used to train a statistical classifier to reliably predict individual child outcomes across three core domains: achievement, behaviour and cognitive ability. PROBIt significantly advances our understanding of features that confer risk and resilience to different neurodevelopmental outcomes and has important implications for clinical diagnosis and rehabilitation of children with early brain insults.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-COG - Consolidator Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-CoG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
B4 7ET Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.