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Mechanisms and regulation of inflammasome-associated programmed cell death

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Publications

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

Author(s): Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H.V. Saavedra, Nathalia M. de Vasconcelos, Amanda Gonçalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D’Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
Published in: Cell Reports, Issue 21/12, 2017, Page(s) 3427-3444, ISSN 2211-1247
DOI: 10.1016/j.celrep.2017.11.088

Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease

Author(s): Hanne Van Gorp, Nina Van Opdenbosch, Mohamed Lamkanfi
Published in: Cold Spring Harbor Perspectives in Biology, 2018, Page(s) a028563, ISSN 1943-0264
DOI: 10.1101/cshperspect.a028563

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

Author(s): Apurva Kanneganti, R.K. Subbarao Malireddi, Pedro H.V. Saavedra, Lieselotte Vande Walle, Hanne Van Gorp, Hiroto Kambara, Heather Tillman, Peter Vogel, Hongbo R. Luo, Ramnik J. Xavier, Hongbo Chi, Mohamed Lamkanfi
Published in: The Journal of Experimental Medicine, Issue 215/6, 2018, Page(s) 1519-1529, ISSN 0022-1007
DOI: 10.1084/jem.20172060

The emerging roles of inflammasome‐dependent cytokines in cancer development

Author(s): Hanne Van Gorp, Mohamed Lamkanfi
Published in: EMBO reports, Issue 20/6, 2019, ISSN 1469-221X
DOI: 10.15252/embr.201847575

Caspases in Cell Death, Inflammation, and Disease

Author(s): Nina Van Opdenbosch, Mohamed Lamkanfi
Published in: Immunity, Issue 50/6, 2019, Page(s) 1352-1364, ISSN 1074-7613
DOI: 10.1016/j.immuni.2019.05.020

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Author(s): Pedro H. V. Saavedra, Linyan Huang, Farzaneh Ghazavi, Stephanie Kourula, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeele, Mohamed Lamkanfi
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-07386-5

DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

Author(s): Nathalia M de Vasconcelos, Gwendolyn Vliegen, Amanda Gonçalves, Emilie De Hert, Rosa Martín-Pérez, Nina Van Opdenbosch, Anvesh Jallapally, Ruth Geiss-Friedlander, Anne-Marie Lambeir, Koen Augustyns, Pieter Van Der Veken, Ingrid De Meester, Mohamed Lamkanfi
Published in: Life Science Alliance, Issue 2/1, 2019, Page(s) e201900313, ISSN 2575-1077
DOI: 10.26508/lsa.201900313

Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis

Author(s): Nathalia M. de Vasconcelos, Mohamed Lamkanfi
Published in: Cold Spring Harbor Perspectives in Biology, 2019, Page(s) a036392, ISSN 1943-0264
DOI: 10.1101/cshperspect.a036392

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Author(s): Lieselotte Vande Walle, Irma B. Stowe, Pavel Šácha, Bettina L. Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H. V. Saavedra, Petr Šimon, Vladimír Šubrt, Libor Kostka, Craig E. Stivala, Victoria C. Pham, Steven T. Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi
Published in: PLOS Biology, Issue 17/9, 2019, Page(s) e3000354, ISSN 1545-7885
DOI: 10.1371/journal.pbio.3000354