Mechanisms and regulation of inflammasome-associated programmed cell death

Project Information

PyroPop

Grant agreement ID: 683144

DOI

10.3030/683144

Project closed

EC signature date 22 June 2016

Start date 1 January 2017

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 997 915,00

EU contribution

€ 1 997 915,00

Coordinated by

UNIVERSITEIT GENT
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Therapeutic modulation of inflammasome pathways

Author(s): Dhruv Chauhan,Lieselotte Vande Walle,Mohamed Lamkanfi
Published in: Immunological Reviews, 2020, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.12908

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax

Author(s): Filip Van Hauwermeiren, Nina Van Opdenbosch, Hanne Van Gorp, Nathalia de Vasconcelos, Geert van Loo, Peter Vandenabeele, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
Published in: Proc Natl Acad Sci U S A., 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2116415119

Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever

Author(s): Hanne Van Gorp, Linyan Huang, Pedro Saavedra, Marnik Vuylsteke, Tomoko Asaoka, Giusi Prencipe, Antonella Insalaco, Benson Ogunjimi, Jerold Jeyaratnam, Ilaria Cataldo, Peggy Jacques, Karim Vermaelen, Melissa Dullaers, Rik Joos, Vito Sabato, Alessandro Stella, Joost Frenkel, Fabrizio De Benedetti, Joke Dehoorne, Filomeen Haerynck, Giuseppe Calamita, Piero Portincasa, Mohamed Lamkanfi
Published in: Annals of the Rheumatic Diseases, 2020, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-216701

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

Author(s): Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi
Published in: Cell Reports, Issue 2, 2020, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107959

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

Author(s): Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H.V. Saavedra, Nathalia M. de Vasconcelos, Amanda Gonçalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D’Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
Published in: Cell Reports, Issue 21/12, 2017, Page(s) 3427-3444, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.11.088

Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease

Author(s): Hanne Van Gorp, Nina Van Opdenbosch, Mohamed Lamkanfi
Published in: Cold Spring Harbor Perspectives in Biology, 2018, Page(s) a028563, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a028563

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

Author(s): Apurva Kanneganti, R.K. Subbarao Malireddi, Pedro H.V. Saavedra, Lieselotte Vande Walle, Hanne Van Gorp, Hiroto Kambara, Heather Tillman, Peter Vogel, Hongbo R. Luo, Ramnik J. Xavier, Hongbo Chi, Mohamed Lamkanfi
Published in: The Journal of Experimental Medicine, Issue 215/6, 2018, Page(s) 1519-1529, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20172060

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

Author(s): Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens, Mohamed Lamkanfi
Published in: Cell Death & Differentiation, 2018, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-018-0106-7

The emerging roles of inflammasome‐dependent cytokines in cancer development

Author(s): Hanne Van Gorp, Mohamed Lamkanfi
Published in: EMBO reports, Issue 20/6, 2019, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201847575

Caspases in Cell Death, Inflammation, and Disease

Author(s): Nina Van Opdenbosch, Mohamed Lamkanfi
Published in: Immunity, Issue 50/6, 2019, Page(s) 1352-1364, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2019.05.020

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Author(s): Pedro H. V. Saavedra, Linyan Huang, Farzaneh Ghazavi, Stephanie Kourula, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeele, Mohamed Lamkanfi
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07386-5

DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

Author(s): Nathalia M de Vasconcelos, Gwendolyn Vliegen, Amanda Gonçalves, Emilie De Hert, Rosa Martín-Pérez, Nina Van Opdenbosch, Anvesh Jallapally, Ruth Geiss-Friedlander, Anne-Marie Lambeir, Koen Augustyns, Pieter Van Der Veken, Ingrid De Meester, Mohamed Lamkanfi
Published in: Life Science Alliance, Issue 2/1, 2019, Page(s) e201900313, ISSN 2575-1077
Publisher: EMBO Press, Rockefeller University Press, Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.201900313

Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis

Author(s): Nathalia M. de Vasconcelos, Mohamed Lamkanfi
Published in: Cold Spring Harbor Perspectives in Biology, 2019, Page(s) a036392, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a036392

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Author(s): Lieselotte Vande Walle, Irma B. Stowe, Pavel Šácha, Bettina L. Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H. V. Saavedra, Petr Šimon, Vladimír Šubrt, Libor Kostka, Craig E. Stivala, Victoria C. Pham, Steven T. Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi
Published in: PLOS Biology, Issue 17/9, 2019, Page(s) e3000354, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3000354