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Design of polyPEPTIdes diblock copolymers as emulsifiers to produce safe, controlled and reliable novel stimuli-responsive nanoCAPSules for skin care applications

Objective

PeptiCaps aims at producing and validating a new family of stimuli-responsive nanocapsules able to encapsulate efficiently and protect specific active ingredients for skin care application. Those nanocapsules will be assembled by nanoemulsion technique using amphiphilic and biocompatible polypeptides diblock copolymers with one hydrophilic poly(ethylene glycol) block and one hydrophobic polypeptide block. Adjustment of the length of each block to finely tune the hydrophilic/Lipophilic balance of the macroemulsifier will allow the encapsulation of either hydrophobic or hydrophilic active ingredients. In addition, polypeptides block will be specifically designed to respond to changes in pH and the presence of enzyme occurring for the skin conditions targeted to allow a triggered release of the active ingredient. After scaling-up selected macroemulsifiers under GMP-like process, two manufacturing processes will be used for the production of the nanocapsules, i.e. high-pressure homogenizer and tubular flow contactor. The most promising process will be selected to produce selected nanocapsules. Physico-chemical properties and (eco)toxicity of the nanocapsules will be extensively characterised using techniques and protocols recommended by the EU Cosmetic regulation to establish their risk and safety assessment. The advantages of safe nanocapsules from PeptiCaps will be demonstrated on validated relevant skin models for each application. All results obtained will be gathered to constitute a Dossier for the validation of the nanocapsules as cosmetic product by the authorities. In addition, PeptiCaps will actively participate to the standardization for nano-safety by developing software to predict the toxicity of nanomaterials (CORAL). Finally, a business plan will be elaborated for the commercialization of PeptiCaps nanocapsules for all cosmetic applications as well as other markets (dermatology and food) to ensure full exploitation of the PeptiCaps technology.

Call for proposal

H2020-NMP-2014-2015

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Sub call

H2020-NMP-PILOTS-2015

Coordinator

FUNDACION CIDETEC
Net EU contribution
€ 895 000,00
Address
Paseo Miramon 196 Parque Tecnologico De Miramon
20014 San Sebastian
Spain

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Other funding
€ 0,00

Participants (11)

UNIVERSITE DE BORDEAUX
France
Net EU contribution
€ 272 500,00
Address
Place Pey Berland 35
33000 Bordeaux

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT POLYTECHNIQUE DE BORDEAUX
France
Net EU contribution
€ 97 825,00
Address
Av Du Docteur Albert Schweitzer 1
33402 Talence

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 46 953,75
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spain
Net EU contribution
€ 460 656,25
Address
Barrio Sarriena S N
48940 Leioa

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Region
Noreste País Vasco Bizkaia
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
AHAVA DEAD SEA LABORATORIES LTD
Israel
Net EU contribution
€ 371 522,50
Address
Arava Street 1
70150 Airport City

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
POLYPEPTIDE THERAPEUTIC SOLUTIONS SOCIEDAD LIMITADA
Spain
Net EU contribution
€ 482 875,00
Address
Parque Tecnologico Calle Benjamin Franklin 19
46980 Valencia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITE LYON 1 CLAUDE BERNARD
France
Net EU contribution
€ 288 447,50
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 130 646,25
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
ANGEL CONSULTING SAS DI MATTEO ZANOTTI RUSSO & C
Italy
Net EU contribution
€ 147 500,00
Address
Via San Senatore 14
20122 Milano

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Net EU contribution
€ 435 500,00
Address
Via Mario Negri 2
20156 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Other funding
€ 0,00
SPINVERSE OY
Finland
Net EU contribution
€ 222 867,50
Address
Keilasatama 5
02150 Espoo

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00