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Design of polyPEPTIdes diblock copolymers as emulsifiers to produce safe, controlled and reliable novel stimuli-responsive nanoCAPSules for skin care applications

Obiettivo

PeptiCaps aims at producing and validating a new family of stimuli-responsive nanocapsules able to encapsulate efficiently and protect specific active ingredients for skin care application. Those nanocapsules will be assembled by nanoemulsion technique using amphiphilic and biocompatible polypeptides diblock copolymers with one hydrophilic poly(ethylene glycol) block and one hydrophobic polypeptide block. Adjustment of the length of each block to finely tune the hydrophilic/Lipophilic balance of the macroemulsifier will allow the encapsulation of either hydrophobic or hydrophilic active ingredients. In addition, polypeptides block will be specifically designed to respond to changes in pH and the presence of enzyme occurring for the skin conditions targeted to allow a triggered release of the active ingredient. After scaling-up selected macroemulsifiers under GMP-like process, two manufacturing processes will be used for the production of the nanocapsules, i.e. high-pressure homogenizer and tubular flow contactor. The most promising process will be selected to produce selected nanocapsules. Physico-chemical properties and (eco)toxicity of the nanocapsules will be extensively characterised using techniques and protocols recommended by the EU Cosmetic regulation to establish their risk and safety assessment. The advantages of safe nanocapsules from PeptiCaps will be demonstrated on validated relevant skin models for each application. All results obtained will be gathered to constitute a Dossier for the validation of the nanocapsules as cosmetic product by the authorities. In addition, PeptiCaps will actively participate to the standardization for nano-safety by developing software to predict the toxicity of nanomaterials (CORAL). Finally, a business plan will be elaborated for the commercialization of PeptiCaps nanocapsules for all cosmetic applications as well as other markets (dermatology and food) to ensure full exploitation of the PeptiCaps technology.

Invito a presentare proposte

H2020-NMP-PILOTS-2015
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Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

FUNDACION CIDETEC
Indirizzo
Paseo Miramon 196 Parque Tecnologico De Miramon
20014 San Sebastian
Spagna
Tipo di attività
Research Organisations
Contributo UE
€ 895 000

Partecipanti (8)

UNIVERSITE DE BORDEAUX
Francia
Contributo UE
€ 417 278,75
Indirizzo
Place Pey Berland 35
33000 Bordeaux
Tipo di attività
Higher or Secondary Education Establishments
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spagna
Contributo UE
€ 460 656,25
Indirizzo
Barrio Sarriena S N
48940 Leioa
Tipo di attività
Higher or Secondary Education Establishments
AHAVA DEAD SEA LABORATORIES LTD
Israele
Contributo UE
€ 371 522,50
Indirizzo
Arava Street 1
70150 Airport City
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
POLYPEPTIDE THERAPEUTIC SOLUTIONS SOCIEDAD LIMITADA
Spagna
Contributo UE
€ 482 875
Indirizzo
Parque Tecnologico Calle Benjamin Franklin 19
46980 Valencia
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE LYON 1 CLAUDE BERNARD
Francia
Contributo UE
€ 419 093,75
Indirizzo
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Tipo di attività
Higher or Secondary Education Establishments
ANGEL CONSULTING SAS DI MATTEO ZANOTTI RUSSO & C
Italia
Contributo UE
€ 147 500
Indirizzo
Via San Senatore 14
20122 Milano
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italia
Contributo UE
€ 435 500
Indirizzo
Via Mario Negri 2
20156 Milano
Tipo di attività
Research Organisations
SPINVERSE OY
Finlandia
Contributo UE
€ 222 867,50
Indirizzo
Keilasatama 5
02150 Espoo
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)