CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level

Project Information

CellViewer

Grant agreement ID: 686637

DOI

10.3030/686637

Project closed

EC signature date 6 November 2015

Start date 1 February 2016

End date 30 September 2020

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 3 988 752,50

EU contribution

€ 3 988 752,50

Coordinated by

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

Final report on dissemination and exploitation activities

Delivery of the final report on dissemination and exploitation activities

Quality plan

Development of a project quality plan

Final report

Delivery of the final report, including a publishable summary

Websites, patent fillings, videos etc. (1)

Project website

Project website (public)

Publications

Peer reviewed articles (9)

Visualizing the genome in high resolution challenges our textbook understanding

Author(s): Melike Lakadamyali, Maria Pia Cosma
Published in: Nature Methods, Issue 17/4, 2020, Page(s) 371-379, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-020-0758-3

Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions

Author(s): Francesco Aulicino, Elisa Pedone, Francesco Sottile, Frederic Lluis, Lucia Marucci, Maria Pia Cosma
Published in: Stem Cell Reports, Issue 15/3, 2020, Page(s) 646-661, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.07.019

Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells

Author(s): Ilda Theka, Francesco Sottile, Marco Cammisa, Sarah Bonnin, Marta Sanchez-Delgado, Umberto Di Vicino, Maria Victoria Neguembor, Karthik Arumugam, Francesco Aulicino, David Monk, Andrea Riccio, Maria Pia Cosma
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-37442-5

Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development

Author(s): João Frade, Shoma Nakagawa, Paola Cortes, Umberto di Vicino, Neus Romo, Frederic Lluis, Maria Pia Cosma
Published in: Science Advances, Issue 5/10, 2019, Page(s) eaax4199, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aax4199

Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

Author(s): Pablo Aurelio Gómez-García, Stephanie Portillo-Ledesma, Maria Victoria Neguembor, Martina Pesaresi, Walaa Oweis, Talia Rohrlich, Stefan Wieser, Eran Meshorer, Tamar Schlick, Maria Pia Cosma, Melike Lakadamyali
Published in: Cell Reports, Issue 34/2, 2021, Page(s) 108614, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108614

Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo

Author(s): Jason Otterstrom, Alvaro Castells-Garcia, Chiara Vicario, Pablo A Gomez-Garcia, Maria Pia Cosma, Melike Lakadamyali
Published in: Nucleic Acids Research, Issue 47/16, 2019, Page(s) 8470-8484, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz593

PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation

Author(s): Gajendra Kumar Azad, Kenji Ito, Badi Sri Sailaja, Alva Biran, Malka Nissim-Rafinia, Yasuhiro Yamada, David T. Brown, Takumi Takizawa, Eran Meshorer
Published in: The Journal of Cell Biology, Issue 217/2, 2018, Page(s) 473-481, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201703141

(Po)STAC (Polycistronic SunTAg modified CRISPR) enables live-cell and fixed-cell super-resolution imaging of multiple genes

Author(s): Maria V Neguembor, Ruben Sebastian-Perez, Francesco Aulicino, Pablo A Gomez-Garcia, Maria P Cosma, Melike Lakadamyali
Published in: Nucleic Acids Research, Issue 46/5, 2017, Page(s) e30-e30, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx1271

Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis

Author(s): Francesco Sottile, Francesco Aulicino, Ilda Theka & Maria Pia Cosma
Published in: Scientific Reports, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep36863

Intellectual Property Rights

Patent (1)

METHOD FOR QUANTIFYING PROTEIN COPY-NUMBER

Application/Publication number: EP 17382394
Date: 2017-06-23
Applicant(s): FUNDACIO INSTITUT DE CIENCIES FOTONIQUES