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CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level


Final report on dissemination and exploitation activities

Delivery of the final report on dissemination and exploitation activities

Quality plan

Development of a project quality plan

Final report

Delivery of the final report, including a publishable summary


Visualizing the genome in high resolution challenges our textbook understanding

Author(s): Melike Lakadamyali, Maria Pia Cosma
Published in: Nature Methods, Issue 17/4, 2020, Page(s) 371-379, ISSN 1548-7091
DOI: 10.1038/s41592-020-0758-3

Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions

Author(s): Francesco Aulicino, Elisa Pedone, Francesco Sottile, Frederic Lluis, Lucia Marucci, Maria Pia Cosma
Published in: Stem Cell Reports, Issue 15/3, 2020, Page(s) 646-661, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2020.07.019

Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells

Author(s): Ilda Theka, Francesco Sottile, Marco Cammisa, Sarah Bonnin, Marta Sanchez-Delgado, Umberto Di Vicino, Maria Victoria Neguembor, Karthik Arumugam, Francesco Aulicino, David Monk, Andrea Riccio, Maria Pia Cosma
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-018-37442-5

Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development

Author(s): João Frade, Shoma Nakagawa, Paola Cortes, Umberto di Vicino, Neus Romo, Frederic Lluis, Maria Pia Cosma
Published in: Science Advances, Issue 5/10, 2019, Page(s) eaax4199, ISSN 2375-2548
DOI: 10.1126/sciadv.aax4199

Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

Author(s): Pablo Aurelio Gómez-García, Stephanie Portillo-Ledesma, Maria Victoria Neguembor, Martina Pesaresi, Walaa Oweis, Talia Rohrlich, Stefan Wieser, Eran Meshorer, Tamar Schlick, Maria Pia Cosma, Melike Lakadamyali
Published in: Cell Reports, Issue 34/2, 2021, Page(s) 108614, ISSN 2211-1247
DOI: 10.1016/j.celrep.2020.108614

Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo

Author(s): Jason Otterstrom, Alvaro Castells-Garcia, Chiara Vicario, Pablo A Gomez-Garcia, Maria Pia Cosma, Melike Lakadamyali
Published in: Nucleic Acids Research, Issue 47/16, 2019, Page(s) 8470-8484, ISSN 0305-1048
DOI: 10.1093/nar/gkz593

PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation

Author(s): Gajendra Kumar Azad, Kenji Ito, Badi Sri Sailaja, Alva Biran, Malka Nissim-Rafinia, Yasuhiro Yamada, David T. Brown, Takumi Takizawa, Eran Meshorer
Published in: The Journal of Cell Biology, Issue 217/2, 2018, Page(s) 473-481, ISSN 0021-9525
DOI: 10.1083/jcb.201703141

(Po)STAC (Polycistronic SunTAg modified CRISPR) enables live-cell and fixed-cell super-resolution imaging of multiple genes

Author(s): Maria V Neguembor, Ruben Sebastian-Perez, Francesco Aulicino, Pablo A Gomez-Garcia, Maria P Cosma, Melike Lakadamyali
Published in: Nucleic Acids Research, Issue 46/5, 2017, Page(s) e30-e30, ISSN 0305-1048
DOI: 10.1093/nar/gkx1271

Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis

Author(s): Francesco Sottile, Francesco Aulicino, Ilda Theka & Maria Pia Cosma
Published in: Scientific Reports, 2016, ISSN 2045-2322
DOI: 10.1038/srep36863