CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level

Información del proyecto

CellViewer

Identificador del acuerdo de subvención: 686637

DOI 10.3030/686637

Proyecto cerrado

Fecha de la firma de la CE 6 Noviembre 2015

Fecha de inicio 1 Febrero 2016

Fecha de finalización 30 Septiembre 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total € 3 988 752,50

Aportación de la UE € 3 988 752,50

Coordinado por

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain

Resultado final

Documents, reports (3)

Final report on dissemination and exploitation activities

Delivery of the final report on dissemination and exploitation activities

Quality plan

Development of a project quality plan

Final report

Delivery of the final report, including a publishable summary

Websites, patent fillings, videos etc. (1)

Project website

Project website (public)

Publicaciones

Peer reviewed articles (9)

Visualizing the genome in high resolution challenges our textbook understanding

Autores: Melike Lakadamyali, Maria Pia Cosma
Publicado en: Nature Methods, Edición 17/4, 2020, Página(s) 371-379, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-020-0758-3

Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions

Autores: Francesco Aulicino, Elisa Pedone, Francesco Sottile, Frederic Lluis, Lucia Marucci, Maria Pia Cosma
Publicado en: Stem Cell Reports, Edición 15/3, 2020, Página(s) 646-661, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2020.07.019

Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells

Autores: Ilda Theka, Francesco Sottile, Marco Cammisa, Sarah Bonnin, Marta Sanchez-Delgado, Umberto Di Vicino, Maria Victoria Neguembor, Karthik Arumugam, Francesco Aulicino, David Monk, Andrea Riccio, Maria Pia Cosma
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-37442-5

Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development

Autores: João Frade, Shoma Nakagawa, Paola Cortes, Umberto di Vicino, Neus Romo, Frederic Lluis, Maria Pia Cosma
Publicado en: Science Advances, Edición 5/10, 2019, Página(s) eaax4199, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aax4199

Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

Autores: Pablo Aurelio Gómez-García, Stephanie Portillo-Ledesma, Maria Victoria Neguembor, Martina Pesaresi, Walaa Oweis, Talia Rohrlich, Stefan Wieser, Eran Meshorer, Tamar Schlick, Maria Pia Cosma, Melike Lakadamyali
Publicado en: Cell Reports, Edición 34/2, 2021, Página(s) 108614, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108614

Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo

Autores: Jason Otterstrom, Alvaro Castells-Garcia, Chiara Vicario, Pablo A Gomez-Garcia, Maria Pia Cosma, Melike Lakadamyali
Publicado en: Nucleic Acids Research, Edición 47/16, 2019, Página(s) 8470-8484, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkz593

PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation

Autores: Gajendra Kumar Azad, Kenji Ito, Badi Sri Sailaja, Alva Biran, Malka Nissim-Rafinia, Yasuhiro Yamada, David T. Brown, Takumi Takizawa, Eran Meshorer
Publicado en: The Journal of Cell Biology, Edición 217/2, 2018, Página(s) 473-481, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201703141

(Po)STAC (Polycistronic SunTAg modified CRISPR) enables live-cell and fixed-cell super-resolution imaging of multiple genes

Autores: Maria V Neguembor, Ruben Sebastian-Perez, Francesco Aulicino, Pablo A Gomez-Garcia, Maria P Cosma, Melike Lakadamyali
Publicado en: Nucleic Acids Research, Edición 46/5, 2017, Página(s) e30-e30, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkx1271

Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis

Autores: Francesco Sottile, Francesco Aulicino, Ilda Theka & Maria Pia Cosma
Publicado en: Scientific Reports, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep36863

Derechos de propiedad intelectual

Patent (1)

METHOD FOR QUANTIFYING PROTEIN COPY-NUMBER

Número de solicitud/publicación: EP 17382394
Fecha: 2017-06-23