Reliable Novel Liquid Biopsy technology for early detection of colorectal cancer

Objective

The overall aim of LIQBIOPSENS project is the further development and validation in real settings of a novel diagnostic platform for the early and fast detection of ctDNA and their KRAS and BRAF mutations associated to colorectal cancer through blood samples. The main features of LIQBIOPSENS are: reliability (detection rates vary from 95–100 %), low-cost (40-50 € per sample analysis), sensitivity (in the zM range), multiplexing capabilities (analysis of 27 KRAS and BRAF mutations simultaneously), short analysis time (30-60 min.), user-friendly interface and flexibility. Solution proposed by the LIQBIOPSENS project relies on the multidisciplinary integration of different Key Enabled Technologies: microelectronics, microfluidics, nanomaterials and genomics. In particular, LIQBIOPSENS platform is based on the integration of two novel complementary technologies. On the one hand, the revolutionary DGL© technology property of DestiNA Genomics Ltd, capable of delivering faster, more error-free detection of nucleic acids and their mutations than current enzyme-based detection systems, making 'false positive' results a thing of the past. On the other hand, a novel high resolution acoustic wave microsensor technology property of AWSensors, that allows an accurate, inexpensive, label-free, direct and real time transduction method to quantitatively evaluate the results of the application of the above mentioned DGL© technique.

Field of science

• /social sciences/economics and business/business and management/innovation management
• /medical and health sciences/clinical medicine/cancer/colorectal cancer
• /medical and health sciences/health sciences/public and environmental health
• /medical and health sciences/clinical medicine/cancer/breast cancer
• /natural sciences/biological sciences/genetics and heredity/mutation
• /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid

Programme(s)

• H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Topic(s)

• ICT-28-2015 - Cross-cutting ICT KETs

Call for proposal

H2020-ICT-2015
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

ADVANCED WAVE SENSORS S.L.

Address

C/ Ciscar 40-8
46005 Valencia
Spain

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU contribution

€ 415 668,75

Participants (6)

DESTINA GEONOMICS LTD

United Kingdom

EU contribution

€ 386 281,88

Address

7 11 Melville Street
EH3 7JA Edinbourgh

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

IDRYMA TECHNOLOGIAS KAI EREVNAS

Greece

EU contribution

€ 450 000

Address

N Plastira Str 100
70013 Irakleio

Activity type

Research Organisations

SERVICIO ANDALUZ DE SALUD

Spain

EU contribution

€ 433 750

Address

Avenida De La Constitucion 18
41071 Sevilla

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

BEABLE SL

Participation ended

Spain

EU contribution

€ 0

Address

Calle Genova 7 5 Izq Esc Int 7
28004 Madrid

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU contribution

€ 501 625

Address

Place De L Universite 1
1348 Louvain La Neuve

Activity type

Higher or Secondary Education Establishments

SISTEMAS GENOMICOS SL

Spain

EU contribution

€ 119 875

Address

Ronda G Marconi - Parque Tecnologico De Valencia 6
46980 Paterna

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)