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Automated diagnostic platform, data management system and innovative communication tool, for improving the impact of malaria vector control interventions

Deliverables

Report on fluidic layouts

D3.7 Report on fluidic layouts: Report for the function and performance of the serial microfluidic reaction chambers (mo. 27)

Periodic report 1

D1.2 Interim report submitted to the EC: Detailed report of the key outputs from project

First Report on communication activities

Report on communication activities: Description of communication activities (presentations in conferences etc), of DMC-MALVEC activities and outcomes

Agenda of the Startup meeting

Protocol of the Start-up meeting: Agenda and detailed program of the Start up meeting

First Annual plan for dissemination

Annual plan for dissemination of information/knowledge and external communication: Description of planned activities that serve dissemination of DMC-MALVEC activities and outcomes (mo. 12, 24, 36 & 48)

Exploitation Plan

D6.5 Exploitation Plan: Detailed plan for the exploitation of project results and translation to market, which will summarise the key innovations of the project and its components, and will outline an exploitation/commercialisation strategy, including target groups (end users), impact, IP, competitive technologies, and routes to access to market (mo. 18)

Second Report on communication activities

Report on communication activities: Description of communication activities (presentations in conferences etc), of DMC-MALVEC activities and outcomes

Report of lab testing of systems diagnostic performance

D3.6 Report of lab testing of systems diagnostic performance: Detailed report for the diagnostic performance of the LabDisk, i.e. accuracy and sensitivity versus standard individual tube assays (mo. 27)

Third Report on communication activities

Report on communication activities: Description of communication activities (presentations in conferences etc), of DMC-MALVEC activities and outcomes

Report on NA assay protocol (extraction and amplification)

D3.1 Report on NA assay protocol (extraction and amplification): Detailed optimised protocols and assays for the extraction (mo. 12)

Annual plan for dissemination of information/knowledge and external communication

Annual plan for dissemination of information/knowledge and external communication: Description of planned activities that serve dissemination of DMC-MALVEC activities and outcomes (mo. 12, 24, 36 & 48)

Quality control handbook

D2.4 Quality control handbook: specified procedures (SOPs), roadmap and guidelines for QC in each process (mo. 15).

Second Annual plan for dissemination of information/knowledge and external communication

Annual plan for dissemination of information/knowledge and external communication: Description of planned activities that serve dissemination of DMC-MALVEC activities and outcomes

Documented baseline information for the DDMS and GAME requirements

D2.3 Documented baseline information for the DDMS and GAME requirements: All requirements and technical details that are required for the DDMS and GAME, based on end user analysis, summarised in an Box format, and supported by explanatory text (mo. 6).

Risk management plan

D2.2 Risk management plan: Detailed description of risks as project begins and evolves, and contingency plan - table forma, and explanatory text for actions (mo. 6).

Third Annual newsletter

Annual newsletter summarizing key activities and results of network suitable for lay audience: copies of the annual newsletters with key outputs and description of activities

Fourth Annual newsletter

Annual newsletter summarizing key activities and results of network suitable for lay audience: copies of the annual newsletters with key outputs and description of activities

First Annual newsletter

Annual newsletter summarizing key activities and results of network suitable for lay audience: copies of the annual newsletters with key outputs and description of activities.

Second Annual newsletter

Annual newsletter summarizing key activities and results of network suitable for lay audience: copies of the annual newsletters with key outputs and description of activities

Project website to support networking and information exchange

D6.1 Project website to support networking and information exchange: functional website address, and details for the networking - information exchange system (mo. 4)

Adapted and expanded GAME

D4.3 Adapted and expanded GAME: Detailed report with modifications and outcome that describe the adaptation and expansion of the GAME for including data outputs from the LabDisk (mo. 12)

TaqMan kits and lyophilised components are manufactured and delivered to partners

D3.3 TaqMan kits & lyophilised components are manufactured and delivered to partners: Reagents will be distributed, and detailed report (what sent - delivered) will be provided (mo. 18)

DDMS adapted to cater for gene expression data and analysis of pools of mosquito data

D4.1 DDMS adapted to cater for gene expression data and analysis of pools of mosquitoes: Report and screenshot examples for the inclusion of gene expression in the DDMS software platform and the ability to analyse and interprete data from pools of mosquitoes (mo. 12)

DDMS configured and validated in Cameroon for collation of historical entomology data

D4.2 DDMS configured and validated in Cameroon for collection of historical data (LSTM, mo. 24) Report and data set examples for the development and pilot implementation (historical data) of the DDMS in Cameroon (mo. 12)

Demo of LabDisk operation at lab scale

D3.5 Demo of Disc operation at lab scale: Detailed reports of laboratory demonstration, for the Disc operation (mo. 24).

Validated GAME available for pilot implementation

D4.4 Validated GAME available for pilot implementation: the added components and new data outputs of the GAME will be validated in Zambia and Ethiopia (with available entomological and insecticide resistance databases) and detailed report and feedback will be provided (mo. 24)

Publications

Converging Human and Malaria Vector Diagnostics with Data Management towards an Integrated Holistic One Health Approach

Author(s): Konstantinos Mitsakakis, Sebastian Hin, Pie Müller, Nadja Wipf, Edward Thomsen, Michael Coleman, Roland Zengerle, John Vontas, Konstantinos Mavridis
Published in: International Journal of Environmental Research and Public Health, Issue 15/2, 2018, Page(s) 259, ISSN 1660-4601
DOI: 10.3390/ijerph15020259

New rapid one-step PCR diagnostic assay for Plasmodium falciparum infective mosquitoes

Author(s): Mary Kefi, Konstantinos Mavridis, Maria L. Simões, George Dimopoulos, Inga Siden-Kiamos, John Vontas
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-19780-6

Detection and Monitoring of Insecticide Resistance Mutations in Anopheles gambiae: Individual vs Pooled Specimens

Author(s): Konstantinos Mavridis, Nadja Wipf, Pie Müller, Mohamed M. Traoré, Gunter Muller, John Vontas
Published in: Genes, Issue 9/10, 2018, Page(s) 479, ISSN 2073-4425
DOI: 10.3390/genes9100479

Automated innovative diagnostic, data management and communication tool, for improving malaria vector control in endemic settings

Author(s): John Vontas, Konstantinos Mitsakakis, Roland Zengerle, Delenasaw Yewhalaw, Chadwick Haadezu Sikaala, Josiane Etang, Matteo Fallani, Bill Carman, Pie Müller, Mouhamadou Chouaïbou, Marlize Coleman, Michael Coleman
Published in: Studies in Health Technology and Informatics, Issue Volume 224: pHealth 2016, 2016, Page(s) 54 - 60
DOI: 10.3233/978-1-61499-653-8-54