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COMPACT BIOPHOTONIC PLATFORM FOR DRUG ALLERGY DIAGNOSIS

Objective

Drug hypersensitivity to antibiotics, mainly Beta-lactams (BLCs) affects more than 2.5 million European citizens. Moreover, preventable adverse drug reactions are estimated in additional hospitalization costs of 1750-4500 €/patient. Currently, the allergy diagnosis is mainly based on the information given by invasive, single, and risky in vivo assays. In daily practice, few in vitro diagnostic methods are available and only used at the tertiary health services. These tests also lack of sensitivity (>0.35 kUA/L) and selectivity (<98%), resulting in an inaccurate diagnosis, analyze few drugs allergens (5), are time consuming (60-180 min), and expensive (30 €/allergen).

COBIOPHAD aims the development of an innovative in vitro diagnostic (IVD) device for diagnosis of IgE-mediated drug allergies by building an integrated biophotonic system based on compact disc technology. For that, key enabling technologies will be integrated in order to achieve high sensitive (<0.1 kUA/L), selective (>98%), multiplexed (10 BLCs), rapid (30 min), and low-cost (2.4 €/allergen) drug allergy test. The solution involves an advanced approach to the diagnosis and management of drug allergy with the aim to ameliorate patient safety.

The consortium comprises multidisciplinary knowledge on optics, electronics, advanced materials, biotechnology, smart microstructures, microfluidics, surface/organic chemistry, allergy, manufacturing systems, and telecom networking. Also, the key industrial actors, present in the consortium, will contribute to the manufacturing and placing the product on the IVD market.

Coordinator

UNIVERSITAT POLITECNICA DE VALENCIA
Net EU contribution
€ 1 026 678,75
Address
Camino De Vera Sn Edificio 3a
46022 Valencia
Spain

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (12)

BIOTRONICS 3D LIMITED
United Kingdom
Net EU contribution
€ 211 596,88
Address
5 Greenwich View Place
E14 9NN London

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
London Inner London — East Tower Hamlets
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 90 684,37
CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
France
Net EU contribution
€ 451 932,00
Address
Avenue Du Doyen Gaston Giraud 191
34000 Montpellier

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Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Research Organisations
Other funding
€ 0,00
EUREXPLOIT LTD
United Kingdom
Net EU contribution
€ 153 128,50
Address
78 Mill Lane
NW6 1JZ London

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
London Inner London — West Camden and City of London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 65 626,50
DR. FOOKE-ACHTERRATH LABORATORIEN GMBH
Germany
Net EU contribution
€ 314 978,13
Address
Habichtweg 16
41468 Neuss

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Düsseldorf Rhein-Kreis Neuss
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 134 990,62
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Spain
Net EU contribution
€ 364 687,00
Address
Av Fernando Abril Martorell 106
46026 Valencia

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Research Organisations
Other funding
€ 0,90
OPTOELECTRONICA - 2001 SA
Romania
Net EU contribution
€ 159 300,75
Address
Strada Lacului 35
077125 Magurele

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Macroregiunea Trei Bucureşti-Ilfov Ilfov
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 68 271,75
STIFTELSEN SINTEF

Participation ended

Norway
Net EU contribution
€ 462 945,00
Address
Strindveien 4
7034 Trondheim
Region
Norge Trøndelag Trøndelag
Activity type
Research Organisations
Other funding
€ 0,00
SONY DADC AUSTRIA

Participation ended

Austria
Net EU contribution
€ 32 373,25
Address
Sonystrasse 20
5081 Anif
Region
Westösterreich Salzburg Salzburg und Umgebung
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 13 874,25
DAS PHOTONICS SL

Participation ended

Spain
Net EU contribution
€ 38 854,27
Address
Cmno De Vera S/n Planta 2 Edificio 8f
46022 Valencia
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 16 651,83
STRATEC CONSUMABLES GMBH
Austria
Net EU contribution
€ 304 097,88
Address
Sonystrasse 20
5081 Anif

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Region
Westösterreich Salzburg Salzburg und Umgebung
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 130 327,66
LUMENSIA SENSORS SL
Spain
Net EU contribution
€ 76 733,23
Address
Calle Islas Canarias 6 Puerta 8
46023 Valencia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 32 885,67
SINTEF AS
Norway
Net EU contribution
€ 137 475,00
Address
Strindvegen 4
7034 Trondheim

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Region
Norge Trøndelag Trøndelag
Activity type
Research Organisations
Other funding
€ 0,00