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COMPACT BIOPHOTONIC PLATFORM FOR DRUG ALLERGY DIAGNOSIS

Objective

Drug hypersensitivity to antibiotics, mainly Beta-lactams (BLCs) affects more than 2.5 million European citizens. Moreover, preventable adverse drug reactions are estimated in additional hospitalization costs of 1750-4500 €/patient. Currently, the allergy diagnosis is mainly based on the information given by invasive, single, and risky in vivo assays. In daily practice, few in vitro diagnostic methods are available and only used at the tertiary health services. These tests also lack of sensitivity (>0.35 kUA/L) and selectivity (<98%), resulting in an inaccurate diagnosis, analyze few drugs allergens (5), are time consuming (60-180 min), and expensive (30 €/allergen).

COBIOPHAD aims the development of an innovative in vitro diagnostic (IVD) device for diagnosis of IgE-mediated drug allergies by building an integrated biophotonic system based on compact disc technology. For that, key enabling technologies will be integrated in order to achieve high sensitive (<0.1 kUA/L), selective (>98%), multiplexed (10 BLCs), rapid (30 min), and low-cost (2.4 €/allergen) drug allergy test. The solution involves an advanced approach to the diagnosis and management of drug allergy with the aim to ameliorate patient safety.

The consortium comprises multidisciplinary knowledge on optics, electronics, advanced materials, biotechnology, smart microstructures, microfluidics, surface/organic chemistry, allergy, manufacturing systems, and telecom networking. Also, the key industrial actors, present in the consortium, will contribute to the manufacturing and placing the product on the IVD market.

Field of science

  • /medical and health sciences/clinical medicine/allergology/drug allergy
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/adverse drug reactions

Call for proposal

H2020-ICT-2015
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

UNIVERSITAT POLITECNICA DE VALENCIA
Address
Camino De Vera Sn Edificio 3A
46022 Valencia
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 026 678,75

Participants (12)

BIOTRONICS 3D LIMITED
United Kingdom
EU contribution
€ 211 596,88
Address
5 Greenwich View Place City Reach Third Floor Suite D
E14 9NN London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
France
EU contribution
€ 451 932
Address
Avenue Du Doyen Gaston Giraud 191
34000 Montpellier
Activity type
Other
EUREXPLOIT LTD
United Kingdom
EU contribution
€ 153 128,50
Address
78 Mill Lane
NW6 1JZ London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DR. FOOKE-ACHTERRATH LABORATORIEN GMBH
Germany
EU contribution
€ 314 978,13
Address
Habichtweg 16
41468 Neuss
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Spain
EU contribution
€ 364 687
Address
Av Fernando Abril Martorell 106
46026 Valencia
Activity type
Research Organisations
OPTOELECTRONICA - 2001 SA
Romania
EU contribution
€ 159 300,75
Address
Bd Tudor Vladimirescu 22 Green Gate Offices Fl 8
050880 Bucharest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STIFTELSEN SINTEF

Participation ended

Norway
EU contribution
€ 462 945
Address
Strindveien 4
7034 Trondheim
Activity type
Research Organisations
SONY DADC AUSTRIA

Participation ended

Austria
EU contribution
€ 32 373,25
Address
Sonystrasse 20
5081 Anif
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DAS PHOTONICS SL

Participation ended

Spain
EU contribution
€ 38 854,27
Address
Cmno De Vera S/n Planta 2 Edificio 8F
46022 Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STRATEC CONSUMABLES GMBH
Austria
EU contribution
€ 304 097,88
Address
Sonystrasse 20
5081 Anif
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LUMENSIA SENSORS SL
Spain
EU contribution
€ 76 733,23
Address
Calle Islas Canarias 6 Puerta 8
46023 Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SINTEF AS
Norway
EU contribution
€ 137 475
Address
Strindvegen 4
7034 Trondheim
Activity type
Research Organisations