Skip to main content

Simulation Modeling of coronary ARTery disease: a tool for clinical decision support

Deliverables

Complete database of clinical, molecular and omics data

Report on the complete non imaging database containing clinical records, phenotype and genotype of each patient

Data Management plan v2

The v2 management plan of the data that will be generated during the project

The prognostic CDSS

This deliverable describes the outcomes of tasks 4.1 and 4.4 with the approach and methodology followed to refine the models as well as the validation results

Error propagation studies

This deliverable describes the outcomes of task 4.7 and will present the detailed error propagation analysis studies, from the source of the data to the clinical decision

SMARTool Report on Gender and Equal Opportunities

This deliverable will provide sex-disaggregated data on the project workforce, on the impact of the working environment and on the career and professional mobility.

The diagnostic CDSS

This deliverable describes the outcomes of the tasks 4.2 and 4.5

Database of clinical, molecular and omics baseline data

Report on creation of a database containing patient non imaging data from WP2 and WP3

Dissemination plan and activities v1

These deliverables include both the planning as well as the implemented activities for disseminating the project research results at M12

Report of Clinical and Regulatory requirements

This deliverable is a report on the CDSS platform application in terms of clinical and regulatory requirements

Dissemination plan and activities v3

This deliverable includes both the planning as well as the implemented activities for disseminating the project research results at M42

The treatment CDSS

This deliverable describes the outcomes of the tasks 4.3 and 4.6.

Data Management plan v1

The v1 management plan of the data that will be generated during the project

Cost effectiveness analysis and impact assessment

Report on the cost-effectiveness evaluation and impact assessment of the platform

Dissemination plan and activities v2

These deliverables include both the planning as well as the implemented activities for disseminating the project research results at M24

Development and validation of CAD stratification algorithm

Report on creation of SMARTool CAD stratification algorithm based on patient-specific non imaging data collected at baseline and follow-up

Assessment of behavioural, ethical, legal, regulatory and social implications of the platform

Report with the implications of the applications of the platform, taking into consideration healthcare-system specific information of the current status of behavioural, ethical, legal, regulatory and social implications

SMARTool promotional material at M6

This deliverable will collect information on the promotional material developed to promote and disseminate SMARTool at M6

SMARTool promotional material at M30

These deliverables will collect information on the promotional material developed to promote and disseminate SMARTool at M30

Searching for OpenAIRE data...

Publications

Non-Invasive Assessment of Coronary Stenoses and Comparison to Invasive Techniques: a proof-of-concept study

Author(s): Panagiota I. Tsompou, Panagiotis K. Siogkas, Antonis I. Sakellarios, Pedro A. Lemos, Lampros K. Michalis, Dimitrios I. Fotiadis
Published in: 30th IEEE International Symposium on Computer-Based Medical Systems (IEEE CBMS 2017), 2017

SMARTool: A tool for clinical decision support for the management of patients with coronary artery disease based on modeling of atherosclerotic plaque process

Author(s): Antonis I. Sakellarios, George Rigas, Vassiliki Kigka, Panagiotis Siogkas, Panagiota Tsompou, Georgia Karanasiou, Themis Exarchos, Ioannis Andrikos, Nikolaos Tachos, Gualtriero Pelosi, Oberdan Parodi, Dimitrios I. Fotiaids
Published in: 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017, Page(s) 96-99
DOI: 10.1109/EMBC.2017.8036771

Computational estimation of the hemodynamic significance of coronary stenoses in arterial branches deriving from CCTA: A proof-of-concept study

Author(s): Panagiotis K. Siogkas, George Rigas, Themis P. Exarchos, Antonis I. Sakellarios, Michail I. Papafaklis, Gualtiero Pelosi, Oberdan Parodi, Lampros K. Michalis, Dimitrios I. Fotiadis
Published in: 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017, Page(s) 1348-1351
DOI: 10.1109/EMBC.2017.8037082

In Silico Assessment of the Effects of Material on Stent Deployment

Author(s): Karanasiou, Nikolaos Tachos, Antonios Sakellarios, Claire Conway, Lampros Michalis, Elazer Edelman, Dimitrios Fotiadis
Published in: 17th IEEE International Conference on BioInformatics and BioEngineering (BIBE 2017), 2017

Analysis of Coronary Computed Tomography Angiography for 3D Reconstruction of Arterial Trees and Plaque Detection

Author(s): P. Siogkas, V. Kigka, A. Sakellarios, T. Exarchos, D. Fotiadis
Published in: IEEE International Conference on Biomedical and Health Informatics (BHI) 16-19 February, 2017, 2017

Computational Hemodynamic Assessment of coronary lesions from Computed Tomography Angiography. A novel approach.

Author(s): P.K. Siogkas, C.D. Anagnostopoulos, T.P. Exarchos, R.Liga, J. Knuuti, Arthur J.H.A. Scholte, M.I. Papafaklis, O. Parodi, L.K. Michalis, D. Neglia, D.I. Fotiadis
Published in: ESC Congress 2016, 2016

A methodology and a software tool for 3D reconstruction of coronary and carotid arteries and atherosclerotic plaques

Author(s): A.I. Sakellarios, G. Rigas, T.P. Exarchos, D.I. Fotiadis
Published in: 2016 IEEE International Conference on Imaging Systems and Techniques (IST), 2016, Page(s) 537-542
DOI: 10.1109/IST.2016.7738284

Coupled computer modeling of atherosclerosis development in the coronary arteries

Author(s): Nenad Filipovic, Velibor Isailovic, Zarko Milosevic, Dalibor Nikolic, Igor Saveljic, Milica Nikolic, Marija Gacic, Bojana Cirkovic-Andjelkovic, Exarchos Themis, Dimitris Fotiadis, Gualtiero Pelosi, Oberdan Parodi
Published in: 17th IEEE International Conference on BioInformatics and BioEngineering, 2017

Simulation of fractional flow reserve and plaque development in the coronary arteries

Author(s): Nenad Filipovic, Arso Vukicevic, Velibor Isailovic, Dalibor Nikolic, Zarko Milosevic, Igor Saveljic,Nikola Jagic, Oberdan Parodi
Published in: ICCB 2017 Abstract Book, 2017

Decision Support System for Selecting Optimal Coronary Revascularization Strategy

Author(s): Lazar Velicki ,Ilija Srdanovic, Aleksandar Redzek, Stamenko Susak, Dalibor Nikolic, Igor Saveljic, Nenad Filipovic
Published in: ICI Meeting 2017, 2017

Computational modeling of plaque development in the coronary arteries

Author(s): Nenad Filipovic, Velibor Isailovic, Zarko Milosevic, Dalibor Nikolic, Igor Saveljic, Milos Radovic, Milica Nikolic, Bojana Cirkovic-Andjelkovic, Exarchos Themis, Dimitris Fotiadis, Gualtiero Pelosi, Oberdan Parodi
Published in: IFMBE Proceedings, Issue 62, 2017, Page(s) 269-274
DOI: 10.1007/978-981-10-4166-2_40

Continuum-discrete modelling of plaque development in the coronary arteries

Author(s): N. Filipovic, I. Saveljic, D. Nikolic, Z. Milosevic, V. Isailovic, O. Parodi, N. Zdravkovic
Published in: 2017

Geometry Optimization of Nitinol Stent Design and Effects on Mechanical Performance: Finite ElementAnalysis

Author(s): Dalibor Nikolić, Nenad Filipović
Published in: 4th South-East European Conference on Computational Mechanics - SEECCM 2017, 2017

Solving Contact Problems Using One-dimensional Finite Elements as Elastic Supports and Application in Angioplasty and Stent Deployment Modeling

Author(s): V. Isailovic, N. Filipovic, M. Kojic
Published in: 4th South-East European Conference on Computational Mechanics - SEECCM 2017, 2017

Prediction of Coronary Plaque Progression Using Data Driven Approach

Author(s): Bojana Andjelkovic Cirkovic, Velibor Isailovic, Dalibor Nikolic, Igor Saveljic, Oberdan Parodi and Nenad Filipovic
Published in: 3rd EAI International Conference on Future Access Enablers of Ubiquitous and Intelligent Infrastructures, Fabulous 2017, 2017

Computer Risk Prediction for Atherosclerosis Development in the Coronary Arteries

Author(s): Nenad Filipovic
Published in: 3rd EAI International Conference on Future Access Enablers of Ubiquitous and Intelligent Infrastructures, Fabulous 2017, 2017

Computer Modeling of Atherosclerosis in the Human Arteries

Author(s): Nenad Filipovic, Velibor Isailovic, Zarko Milosevic, Dalibor Nikolic, Igor Saveljic, Milica Nikolic, Bojana Cirkovic-Andjelkovic, Exarchos Themis, Dimitris Fotiadis, Gualtiero Pelosi, Oberdan Parodi
Published in: International Conference on Innovative Technologies, IN-TECH 2017, 2017

Machine learning approach for predicting the severity of coronary artery disease

Author(s): M. Radovic, B. Andjelkovic, O. Parodi, N. Filipovic
Published in: 66th International Congress of ESCVS, 2017

Simulation of stent deployment in patient-specific coronary artery; models for their hemodynamics analysis

Author(s): D. Nikolić, D. Krsmanovic, I. Koncar, L. Davidovic, O. Parodi, N. Filipović
Published in: 66th International Congress of ESCVS, 2017

A novel concept of the management of coronary artery disease patients based on machine learning risk stratification and computational biomechanics

Author(s): Antonis I. Sakellarios, Nikolaos Tachos, Elena Georga, George Rigas, Vassiliki Kigka, Panagiotis Siogkas, Savvas Kyriakidis, Georgia Karanasiou, Panagiota Tsompou, Ioannis Andrikos, Silvia Rocchiccioli, Gualtriero Pelosi, Oberdan Parodi, Dimitrios I. Fotiadis
Published in: World Congress on Medical Physics & Biomedical Engineering (IUPESM), Prague, Czech Republic, Issue 3-8 June, 2018, Page(s) 629-633
DOI: 10.1007/978-981-10-9035-6_117

A three-dimensional quantification of non-calcified plaque based on computed tomography coronary angiography images: comparison with virtual histology intravascular ultrasound

Author(s): Vassiliki I. Kigka, Antonis Sakellarios, George Rigas, Panagiota Tsobou, Ioannis O. Andrikos, Lampros K. Michalis, Dimitrios I. Fotiadis
Published in: World Congress on Medical Physics & Biomedical Engineering (IUPESM), Prague, Czech Republic, Issue 3-8 June, 2018, Page(s) 207-211
DOI: 10.1007/978-981-10-9035-6_37

A Multimodal Machine Learning Approach to Omics-based Risk Stratification in Coronary Artery Disease

Author(s): Eleni I. Georga, Nikolaos S. Tachos, Antonis I. Sakellarios, Gualtiero Pelosi, Silvia Rocchiccioli, Oberdan Parodi, Lampros K. Michalis, Dimitrios I. Fotiadis
Published in: World Congress on Medical Physics & Biomedical Engineering (IUPESM), Prague, Czech Republic, Issue 3-8 June, 2018, Page(s) 879-882
DOI: 10.1007/978-981-10-9023-3_158

Non-invasive quantification of coronary artery disease in arterial bifurcations using CCTA and CFD: comparison to fractional flow reserve measurements

Author(s): Panagiotis K. Siogkas, Antonis I. Sakellarios, Lampros K. Michalis, Dimitrios I. Fotiadis
Published in: World Congress on Medical Physics & Biomedical Engineering (IUPESM), Prague, Czech Republic, Issue 3-8 June, 2018, Page(s) 639-643
DOI: 10.1007/978-981-10-9035-6_119

Towards Precise Predictive Modelling of Coronary Artery Disease Elaborating on Omics Data

Author(s): Eleni I. Georga, Nikolaos S. Tachos, Antonis I. Sakellarios, Themis P. Exarchos, Silvia Rocchiccioli, Gualtiero Pelosi, Oberdan Parodi, Lampros K. Michalis, Dimitrios I. Fotiadis
Published in: IEEE Conference on Biomedical and Health Informatics (BHI), Las Vegas, Nevada- USA, Issue 4-7 March, 2018

Next generation sequencing of blood mRNAs for the development of a risk stratification algorithm in coronary artery disease.

Author(s): Silvia Rocchiccioli, Moritz Schütte, Christine Voigt, Bodo Lange , Nikolaos Tachos, Eleni Georga, Antonis Sakellarios, Jeff M. Smit, Arthur JHA. Scholte, Dimitris I. Fotiadis, Gualtiero Pelosi, on behalf of SMARTool Study Investigators
Published in: International Work-Conference on Bioinformatics and Biomedical Engineering IWBBIO 2019, 2019

SMARTool H2020 project: an ICT Approach to Coronary Artery Disease Management: Clinical Study Design and Preliminary Data

Author(s): Gualtiero Pelosi1, Silvia Rocchiccioli1, Themis P. Exarchos2, Danilo Neglia3, Arthur Scholte8, Juani Knuuti5, Ronny Buechel4,9, Paolo Stoffella7, Joao Correia6, Michela Rial1, Dimitris I. Fotiadis2, Oberdan Parodi1
Published in: ICCAD 2017, 2017

Immune Response and Coronary Atherosclerosis: Putative Cellular Markers of Plaque Development

Author(s): Silvia Rocchiccioli1, Silverio Sbrana2, Moritz Schuette3, Tatiana Borodina3, Federico Vozzi1, Alexander R. Rosendael4, Danilo Neglia5, Oberdan Parodi1, Gualtiero Pelosi1
Published in: ICCAD 2017, 2017

SMARTool project: an ICT view for coronary artery disease management” 18TH international conference on experimental mechanics

Author(s): Pelosi, Gualtiero, Rocchiccioli Silvia, Exarchos Themis, Neglia Danilo, Scholte Arthur, Knuuti Juani, Buechel Ronny, Barbon Fabio, Correia Joao, Sakellarios Antonis, Fotiadis Dimitris, Rial Michela and Parodi Oberdan
Published in: ICEM 2018, 2018

The impact of genomics in the development of a diagnostic model for stable coronary artery disease

Author(s): S. Rocchiccioli, M. Shuette, N.Tachos, E. Georga, S. Sbrana, J. Campolo, C. Caselli, A. Sakellarios, F. Vozzi, JM. Smit, AJHA. Scholte, D. Neglia, D. I. Fotiadis, O. Parodi, G. Pelosi
Published in: VPH 2018, 2018

nnate Immunity and Coronary Atherosclerosis Progression: putative cellular and molecular marker

Author(s): Rocchiccioli Silvia, Sbrava Silverio, Schuette Moritz, Borodina Tatiana, Vozzi Federico, Campolo Jonica, Caselli Chiara, Rosendael Elexander, Neglia Danilo, Oberdan Parodi, Gualtiero Pelosi
Published in: ICEM 2018, 2018

Scientific and Clinical Framework of the SMARTool Project

Author(s): Parodi O
Published in: CAD risk prediction and stratification: the ICT approach, 2018

SMARTool clinical and biohumoral results

Author(s): Caselli C
Published in: CAD risk prediction and stratification: the ICT approach, 2018

SMARTool lipidomics for ATS risk prediction and point of care testing

Author(s): Rocchiccioli S
Published in: CAD risk prediction and stratification: the ICT approach, 2018

Expected clinical and health-economics impacts of DSS in CAD

Author(s): Pelosi G
Published in: CAD risk prediction and stratification: the ICT approach, 2018

Experimental testing and numerical modeling of stents in the coronary arteries

Author(s): Nenad Filipovic; Dalibor Nikolic; Igor Saveljic; Themis Exarchos; Oberdan Parodi
Published in: Issue 3, 2016
DOI: 10.5281/zenodo.3369679

3D reconstruction of coronary arteries and atherosclerotic plaques based on computed tomography angiography images

Author(s): Vassiliki I. Kigka, George Rigas, Antonis Sakellarios, Panagiotis Siogkas, Ioannis O. Andrikos, Themis P. Exarchos, Dimitra Loggitsi, Constantinos D. Anagnostopoulos, Lampros K. Michalis, Danilo Neglia, Gualtriero Pelosi, Oberdan Parodi, Dimitrios I. Fotiadis
Published in: Biomedical Signal Processing and Control, Issue 40, 2018, Page(s) 286-294, ISSN 1746-8094
DOI: 10.1016/j.bspc.2017.09.009

CARS 2017—Computer Assisted Radiology and Surgery Proceedings of the 31st International Congress and Exhibition Barcelona, Spain, June 20–24, 2017

Author(s): N. Filipovic, V. Isailovic, Z. Milosevic, D. Nikolic, I. Saveljic, M. Nikolic, B. Cirkovic-Andjelkovic, M. Radovic, T. Exarchos, D. Fotiadis, G. Pelosi, O. Parodi
Published in: International Journal of Computer Assisted Radiology and Surgery, Issue 12/S1, 2017, Page(s) 1-286, ISSN 1861-6410
DOI: 10.1007/s11548-017-1588-3

Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers

Author(s): Aliki Tsopela, Sandro Meucci, Silvia Rocchiccioli, Gualtiero Pelosi, Monica Brivio
Published in: Proceedings, Issue 2/8, 2018, Page(s) 390, ISSN 2504-3900
DOI: 10.3390/icem18-05215

Characterization of functionally significant coronary artery disease by a coronary computed tomography angiography-based index: a comparison with positron emission tomography

Author(s): Constantinos D Anagnostopoulos, Panagiotis K Siogkas, Riccardo Liga, Georgios Benetos, Teemu Maaniitty, Antonis I Sakellarios, Iosif Koutagiar, Ioannis Karakitsios, Michail I Papafaklis, Valentina Berti, Roberto Sciagrà, Arthur J H A Scholte, Lampros K Michalis, Oliver Gaemperli, Philipp A Kaufmann, Gualtiero Pelosi, Oberdan Parodi, Juhani Knuuti, Dimitrios I Fotiadis, Danilo Neglia
Published in: European Heart Journal - Cardiovascular Imaging, 2019, ISSN 2047-2404
DOI: 10.1093/ehjci/jey199

Noninvasive CT-based hemodynamic assessment of coronary lesions derived from fast computational analysis: a comparison against fractional flow reserve

Author(s): Panagiotis K. Siogkas, Constantinos D. Anagnostopoulos, Riccardo Liga, Themis P. Exarchos, Antonis I. Sakellarios, George Rigas, Arthur J. H. A. Scholte, M. I. Papafaklis, Dimitra Loggitsi, Gualtiero Pelosi, Oberdan Parodi, Teemu Maaniitty, Lampros K. Michalis, Juhani Knuuti, Danilo Neglia, Dimitrios I. Fotiadis
Published in: European Radiology, 2018, ISSN 0938-7994
DOI: 10.1007/s00330-018-5781-8

Three-dimensional reconstruction and NURBS-based structured meshing of coronary arteries from the conventional X-ray angiography projection images

Author(s): Arso M. Vukicevic, Serkan Çimen, Nikola Jagic, Gordana Jovicic, Alejandro F. Frangi, Nenad Filipovic
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-19440-9

Effects of Geometry Optimization on Mechanical Performance of Nitinol Stent Design: Finite Element Analysis

Author(s): D. Nikolić, N. Filipović
Published in: IPSI BgD Transactions on Advanced Research, 2018, ISSN 1820-4511

Contact Problems: Angioplasty and Stent Deployment Modeling

Author(s): V. Isailović, M. Kojić, N. Filipović
Published in: IPSI BgD Transactions on Advanced Research, 2018, ISSN 1820-4511

Numerical simulation of stent deployment within patient-specific artery and its validation against clinical data

Author(s): Tijana Djukic, Igor Saveljic, Gualtiero Pelosi, Oberdan Parodi, Nenad Filipovic
Published in: Computer Methods and Programs in Biomedicine, Issue 175, 2019, Page(s) 121-127, ISSN 0169-2607
DOI: 10.1016/j.cmpb.2019.04.005

Prediction of Atherosclerotic Plaque Development in an In Vivo Coronary Arterial Segment Based on a Multilevel Modeling Approach

Author(s): Antonis I. Sakellarios, Lorenz Raber, Christos V. Bourantas, Themis P. Exarchos, Lambros S. Athanasiou, Gualtiero Pelosi, Konstantinos C. Koskinas, Oberdan Parodi, Katerina K. Naka, Lampros K. Michalis, Patrick W. Serruys, Hector M. Garcia-Garcia, Stephan Windecker, Dimitrios I. Fotiadis
Published in: IEEE Transactions on Biomedical Engineering, Issue 64/8, 2017, Page(s) 1721-1730, ISSN 0018-9294
DOI: 10.1109/TBME.2016.2619489

Machine Learning Approach for Predicting Wall Shear Distribution for Abdominal Aortic Aneurysm and Carotid Bifurcation Models

Author(s): Milos Jordanski, Milos Radovic, Zarko Milosevic, Nenad Filipovic, Zoran Obradovic
Published in: IEEE Journal of Biomedical and Health Informatics, 2016, Page(s) 1-1, ISSN 2168-2194
DOI: 10.1109/JBHI.2016.2639818

Computer Simulation of Flow through the True and False Lumen of Aortic Dissection

Author(s): Saveljic, L. Velicki, N. Filipovic
Published in: IPSI BgD Transactions on Advanced Research, 2017, ISSN 1820-4511

Safe Operation Assessment of the Cardiovascular Stent

Author(s): Jovčić, A. Vukićević, N. Filipović
Published in: IPSI BgD Transactions on Advanced Research, 2017, ISSN 1820-4511

Available Computational Techniques to Model Atherosclerotic Plaque Progression Implementing a Multi-Level Approach

Author(s): Antonis I. Sakellarios, Georgia Karanasiou, Panagiotis Siogkas, Vasiliki Kigka, Themis Exarchos, George Rigas, Lampros K. Michalis, Dimitrios I. Fotiadis
Published in: Computational Biomechanics for Medicine (From Algorithms to Models and Applications), 2017, Page(s) 39-55
DOI: 10.1007/978-3-319-54481-6_4

Computer Simulation of Electroporation and Drug Transport Through Membranes

Author(s): Nenad Filipovic, Igor Saveljic, Irena Tanaskovic
Published in: Computer Methods in Biomechanics and Biomedical Engineering, 2018, Page(s) 175-180
DOI: 10.1007/978-3-319-59764-5_20

Computer modeling of stent deployment in the coronary artery coupled with plaque progression

Author(s): N. Filipovic, Z. Milosevic, I. Saveljic, D. Nikolic, M. Radovic
Published in: Biomaterials in Clinical Practice, 2018

A targeted LC-MS/MS analysis of the human plasma lipid profile to highlight novel markers of coronary artery disease severity

Author(s): Elena Michelucci, Francesco Finamore, Giovanni Signore, Silvia Rocchiccioli
Published in: ItPA and HPS International XIV Congress 2019, 2019

Biohumoral predictors of coronary atherosclerosis progression in patients with suspected coronary artery disease from the SMARTool Study

Author(s): C Caselli S Rocchiccioli A Rosendael R Buechel A Teresinska M N Pizzi J M Smit M Magnacca S Del Ry F Vozzi J Knuuti G Pelosi O Parodi A Scholte D Neglia SMARTool Investigators
Published in: European Heart Journal, Issue Volume 39, Issue suppl_1, 2018

Low leptin plasma levels are associated with progression of coronary atherosclerosis in patients with stable coronary artery disease from the SMARTool Study

Author(s): Caselli C, Rocchiccioli S, Rosendael A, Buechel R, Teresinska A, Pizzi MN, Smith JM, Poddighe R, Campolo J, Vozzi F, Knuuti J, Pelosi G, Parodi O, Scholte A, Neglia D
Published in: ESC CONGRESS 2019, 2019

Razvoj softverskog alata za trodimenzionalnu rekonstrukciju i biomehaničku analizu zida aorte

Author(s): Milošević, Žarko N.
Published in: Issue 16, 2018