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A Federated Collaborative Care Cure Cloud Architecture for Addressing the Needs of Multi-morbidity and Managing Poly-pharmacy

Deliverables

New Organisational Models for Improved Delivery of Integrated Care

The document presenting the adaptive organisational models developed for improved delivery of patient-centred integrated care and that address the challenges posed by varying contexts

User Training Materials and Preparation Outcomes

The report presenting the training materials prepared for the actual users of the C3-Cloud pilot application and the outcomes of the training workshops organised prior to and at the beginning of pilot application validation

Guidelines for Management of Changes in the Models of Care Delivery

The document presenting the guidelines for smooth management of changes in models of care delivery, which are identified necessary for integrated care services

Test and Evaluation Report for C3-Cloud Components

The report presenting the results of test and evaluation of C3-Cloud software components

Final Report

The final report of the project

Dissemination Plan (a)

The report presenting the dissemination activities till M12, and the plans for the following months

Use Cases and Requirement Specifications of the Pilot Application

Requirements specification of the C3-Cloud pilot application by considering the current application landscape of end-users and the use cases to be piloted

Conceptual Design of the C3-Cloud Architecture

The Conceptual Design document of the C3-Cloud Software Architecture in accordance with the well-established IEEE Std. 1016 Recommended Practice for Software Design Descriptions

Dissemination Plan (c)

The report presenting the dissemination activities till M36, and the plans for the following months

Guidance for the Development of New Patient Pathways and Corresponding Care Plans

The report providing guidance for and development of new patient pathways and corresponding personalised care plans that can perform multi-morbid chronic disease management, by reusing individual clinical guidelines

Functional and Non-functional Testing Criteria for C3-Cloud Components

The document specifying the functional and non-functional testing criteria for C3-Cloud components as a part of the 4-layered C3-Cloud evaluation approach

Design of the Implementation of the Pilot Application Scenarios

The document presenting the detailed design of the C3-Cloud pilot application by considering the differing characteristics of each pilot site

Project Presentation

Presentation of the project

Qualitative and Quantitative Evaluation Criteria for C3-Cloud Pilot Application

The document specifying the qualitative and quantitative evaluation criteria for C3-Cloud pilot application as a part of the 4-layered C3-Cloud evaluation approach

Survey of the State of the Art

A comprehensible survey report in the related research areas addressed by C3Cloud project

Dissemination Plan (b)

The report presenting the dissemination activities till M24, and the plans for the following months

Final Result of Evaluation and Modelling Large-Scale Impact of the C3-Cloud Pilot Application

The document presenting the outcomes of the full evaluation of the C3-Cloud pilot application after 15 months of operation, according to the evaluation criteria defined earlier, and the final version of the large-scale impact model

Interim Evaluation Results for the C3-Cloud Pilot Application

The document presenting the outcomes of the interim evaluation of the C3-Cloud pilot application after 8 months of operation, according to the evaluation criteria defined earlier

Requirements Specification of the C3-Cloud Architecture

The Requirements Specification Document of the C3-Cloud Software Architecture developed in accordance with the well-established standards IEEE Std. 830-1998 and IEEE Std. 1233-1998

Self-Management Training Materials for Increasing Patient Adherence to Care Plans

Static and dynamic self-management training materials for the patients and their informal care givers to increase patient’s adherence and confidence in their care management

Dissemination Plan (d)

The report presenting the dissemination activities till the end of the project, and the plans for beyond the project

Updated Guidance for the Development of New Patient Pathways and Corresponding Care Plans

The revised report with the experience gained in the pilots, providing guidance for and development of new patient pathways and corresponding personalised care plans that can perform multi-morbid chronic disease management, by reusing individual clinical guidelines

Report on Industry Liaison

The report presenting all the industry liaison activities realised during the lifetime of the project

Evidence Based Clinical Guideline Definitions and Flowcharts for Individual Chronic Conditions

The document providing the identified clinical guidelines that are re-presented clearly and enriched with flowcharts, in a way that can be easily understood by the technical partners and modelled in a computer executable manner

Open Research Data Management Plan

A Data Management Plan to determine which of the research data can and will be made open through the Horizon 2020 Pilot Action on Open Research Data

C3-Cloud Coordinated Care and Cure Delivery Platform

Implementation of the Coordinated Care and Cure Delivery Platform and integration of all the technical components implemented in WP5, WP6 and WP7 before deployment at the pilot sites

Personalised Care Plan Development Platform

Implementation of the Personalised Care Plan Development Platform

C3-Cloud Technical Interoperability Implementation Guidelines and Open Source Toolkits

Development of Technical Interoperability Implementation Guidelines and Implementation of the Open Source Toolkits to enable structural interoperability

Deployment of C3-Cloud Pilot Application

Deployment of the pilot application to real life settings

C3-Cloud Semantic Interoperability Platform

Implementation of the C3-Cloud Semantic Interoperability Platform that will enable common understanding of clinical data

Clinical Decision Support Modules for Personalised Care Plan Development and Execution

Implementation of several clinical decision support modules to be used by Personalised Care Plan Development Platform and the Coordinated Care and Cure Delivery Platform

Open Source Privacy and Security Toolkits for the C3-Cloud Architecture

Open source privacy and security toolkits to ensure sensitive patient information is exchanged in a safe and ethical way in the whole ecosystem

Data Collection and Feedback Mechanism

Implementation of the interaction mechanisms to communicate with the patient to establish connection with the formal and informal care givers both synchronously and asynchronously

Responsive Multi-Channel Patient Empowerment Platform

Implementation of the Responsive Multi-Channel Patient Empowerment Platform as the final outcome of WP5 by extending and improving the Medixine Clinic

Publications

Localisation, Personalisation and Delivery of Best Practice Guidelines on an Integrated Care and Cure Cloud Architecture: The C3-Cloud Approach to Managing Multimorbidity

Author(s): George Despotou, Gokce B. Laleci Erturkmen, Mustafa Yuksel, Bunyamin Sarigul, Pontus Lindman, Marie-Christine Jaulent, Jacques Bouaud, Lamine Traore, Sarah N. Lim Choi Keung, Esteban De Manuel, Dolores Verdoy, Antonio De Blas, Nicolas Gonzalez, Mikael Lilja, Marie Sherman, Malte Von Tottleben, Marie Beach, Christopher Marguerie, Liran Karni, Gunnar O. Klein, Dipak Kalra, Rong Chen, Theodoros N. Ar
Published in: Studies in Health Technology and Informatics, Issue 270, 2020, Page(s) 623-627, ISBN 978-1-64368-083-5
Publisher: IOS Press
DOI: 10.3233/shti200235

Personalised Care Plan Management Utilizing Guideline-Driven Clinical Decision Support Systems

Author(s): Gokce Banu Laleci Erturkmen, Mustafa Yuksel, Bunyamin Sarigul, Mikael Lilja, Rong Chen, Theodoros N. Arvanitis
Published in: Studies in Health Technology and Informatics, Issue 247, 2018, Page(s) 750 - 754, ISBN 978-1-61499-852-5
Publisher: IOS Press
DOI: 10.3233/978-1-61499-852-5-750

C3-Cloud: Çoklu morbidite ihtiyaçlarını karşılamak üzere katılımcı ve bütünleşik bakım ve tedavi mimarisi [C3-Cloud: A Federated and Collaborative Care and Cure Cloud Architecture for Addressing the Needs of Multi-Morbidity]

Author(s): G. B. Laleci Erturkmen, M. Yuksel, B. Sarigul, and T. N. Arvanitis
Published in: X International Medical Informatics Conference, Antalya: Turkey, 2017, 2017, Page(s) 5
Publisher: MIACONFERENCES

Secondary use of Electronic Health Records (EHRs) in diabetes research: to what extent have we unlocked their potential?

Author(s): TD Robbins, RCS Tucker and TN Arvanitis
Published in: Diabetic Medicine, Issue 34 (S1), 2017, Page(s) 60 (P81)
Publisher: Wiley

Integrated healthcare in the C3-Cloud project pilots – a technical perspective

Author(s): Sarah N. Lim Choi Keung, Lei Zhao, George Despotou, Theodoros N. Arvanitis
Published in: Digital Health & Care and Safety of Connected Health: Improvement & Applications Conference (DICOH’18), Coventry, UK, 3 May 2018, 2018
Publisher: University of Warwick

Una Arquitectura en la Nube de Atención y Cuidados Colaborativa que Cubre las Necesidades de la Pluripatología y la Gestión de la Polifarmacia, Proyecto C3-CLOUD [A Federated Collaborative Care Cure Cloud Architecture for Addressing the Needs of Multi-Morbidity and Managing Poly-Pharmacy, C3-Cloud Project]

Author(s): D. Verdoy, G. Laleci Erturkmen, M. Yuksel , A. De Bias, N. Gonzalez, and T. Arvanitis
Published in: Libro de Communicationes, IX Congresso Nacional de Atención Sanitaria al Paciente Crónico, Oviedo: Spain, 2017, Page(s) 106-107
Publisher: Oveido

A health informatics approach to risk stratification at hospital discharge for patients with diabetes; assessing strengths of association across patient cohorts and outcomes

Author(s): T Robbins, SN Lim Choi Keung, S Sankaranarayanan, H Randeva and TN Arvanitis
Published in: Diabetic Medicine, Issue 36(S1) Targeting Risk Factors, 2019, Page(s) A65 (P321)
Publisher: Wiley

Male hypogonadism and diabetic foot disease: Retrospective analysis of a poorly understood and under‐researched multi‐morbid disease set

Author(s): T Robbins, G Jobburn, R Rao, TN Arvanitis, H Randeva and N Murthy
Published in: Diabetic Medicine, Issue 36(S1), 2019, Page(s) 125 (P291)
Publisher: Wiley

Concurrent execution of multiple computer-interpretable clinical practice guidelines and their interrelations

Author(s): Eda Bilici, George Despotou, Theodoros N. Arvanitis
Published in: Studies in Health Technology and Informatics, Issue 262, Health Informatics Vision: From Data via Information to Knowledge, 2019, Page(s) 7-10, ISBN 9781614999867
Publisher: IOS Press
DOI: 10.3233/shti190003

Drug Interaction Advisory Service for Clinical Decision Support of Multimordity Patient Centric Care Plans in the C3-Cloud System

Author(s): George Despotou, Mustafa Yuksel, Bunyamin Sarigul, Theodoros N. Arvanitis
Published in: Studies in Health Technology and Informatics, Issue 262, 2019, Page(s) 388 - 391, ISSN 1879-8365
Publisher: IOS Press
DOI: 10.3233/shti190100

Risk factors for readmission of inpatients with diabetes: A systematic review

Author(s): Tim D. Robbins, S.N. Lim Choi Keung, S. Sankar, H. Randeva, T.N. Arvanitis
Published in: Journal of Diabetes and its Complications, Issue 33/5, 2019, Page(s) 398-405, ISSN 1056-8727
Publisher: Elsevier BV
DOI: 10.1016/j.jdiacomp.2019.01.004

Diabetes and the direct secondary use of electronic health records: Using routinely collected and stored data to drive research and understanding

Author(s): Tim Robbins, Sarah N Lim Choi Keung, Sailesh Sankar, Harpal Randeva, Theodoros N Arvanitis
Published in: DIGITAL HEALTH, Issue 4, 2018, Page(s) 205520761880465, ISSN 2055-2076
Publisher: SAGE
DOI: 10.1177/2055207618804650

A Systematic Review Considering Risk factors for Mortality of Patients Discharged from Hospital with a Diagnosis of Diabetes

Author(s): Teesta Mukherjee, Tim Robbins, Sarah N. Lim Choi Keung, Sailesh Sankar, Harpal Randeva, Theodoros N. Arvanitis
Published in: Journal of Diabetes and its Complications, 2020, Page(s) 107705, ISSN 1056-8727
Publisher: Elsevier BV
DOI: 10.1016/j.jdiacomp.2020.107705

Facilitating coordinated Care for Multi-morbidity patients through integrated preventive Clinical Decision Support (C3-Cloud)

Author(s): George Despotou, Mustafa Yuksel, Gokce Laleci, Esteban De Manuel Keenoy, Sarah Lim Choi Keung, Dolores Verdoy Berastegui, Lei Zhao, Theodoros N Arvanitis
Published in: International Journal of Integrated Care, Issue 19/4, 2019, Page(s) 29, ISSN 1568-4156
Publisher: Igitur, Utrecht Publishing and Archiving Services
DOI: 10.5334/ijic.s3029

User-Centered Design of the C3-Cloud Platform for Elderly with Multiple Diseases-Functional Requirements and Application Testing

Author(s): Lamine Traore, Ariane Assele-Kama, Sarah N. Lim Choi Keung, Liran Karni, Gunnar O. Klein, Mikael Lilja, Isabella Scandurra, Dolores Verdoy, Mustafa Yuksel, Theodoros N. Arvanitis, Rosy Tsopra, Marie-Christine Jaulent
Published in: Studies in Health Technology and Informatics, Issue 264, 2019, Page(s) 843-847, ISSN 1879-8365
Publisher: IOS Press
DOI: 10.3233/shti190342

Application of standardised effect sizes to hospital discharge outcomes for people with diabetes

Author(s): Tim Robbins, Sarah N. Lim Choi Keung, Sailesh Sankar, Harpal Randeva, Theodoros N. Arvanitis
Published in: BMC Medical Informatics and Decision Making, Issue 20/1, 2020, ISSN 1472-6947
Publisher: BioMed Central
DOI: 10.1186/s12911-020-01169-z

Addendum to Informatics for Health 2017: Advancing both science and practice

Author(s): Philip Scott, Ronald Cornet, Colin McCowan, Niels Peek
Published in: Journal of Innovation in Health Informatics, Issue 24/3, 2017, Page(s) 291, ISSN 2058-4563
Publisher: BCS, The Chartered Institute for IT
DOI: 10.14236/jhi.v24i3.969

A federated collaborative care cure cloud architecture for addressing the needs of multi-morbidity and managing poly-pharmacy (c3-cloud project)

Author(s): Theodoros N. Arvanitis, Gokce Banu Laleci Erturkmen, Mustafa Yuksel, Antonio De Blas, Nicolas González, Dolores Verdoy, Esteban De Manuel
Published in: International Journal of Integrated Care, Issue 17/5, 2017, Page(s) 182, ISSN 1568-4156
Publisher: Igitur, Utrecht Publishing and Archiving Services
DOI: 10.5334/ijic.3490

Management of personalised guideline-driven care plans addressing the needs of multi-morbidity via clinical decision support services

Author(s): Gokce Banu Laleci Erturkmen, Mustafa Yuksel, Bunyamin Sarigul, Pontus Lindman, Rong Chen, Lei Zhao, Jacques Bouaud, Mikael Lilja, Esteban De Manuel, Dolores Verdoy, Antonio De Blas, Christopher Marguerie, Gunnar Klein, Sarah N. Lim Choi Keung, Theodoros N. Arvanitis
Published in: International Journal of Integrated Care, Issue 18/s2, 2018, Page(s) 132, ISSN 1568-4156
Publisher: Igitur, Utrecht Publishing and Archiving Services
DOI: 10.5334/ijic.s2132

Organizational and care model analysis for c3-cloud deployment preparation

Author(s): Antonio De Blas, Nicolás González, Mikel Ogueta, Dolores Verdoy, Mikael Lilja, Marie Holm Sherman, Christopher Marguerie, Danny Roberts, Marie Beach, Mustafa Yuksel, Gokce Banu Laleci Erturkmen, Theodoros N. Arvanitis
Published in: International Journal of Integrated Care, Issue 18/s2, 2018, Page(s) 335, ISSN 1568-4156
Publisher: Igitur, Utrecht Publishing and Archiving Services
DOI: 10.5334/ijic.s2335

The use of computer-interpretable clinical guidelines to manage care complexities of patients with multimorbid conditions: A review

Author(s): Eda Bilici, George Despotou, Theodoros N Arvanitis
Published in: DIGITAL HEALTH, Issue 4, 2018, Page(s) 205520761880492, ISSN 2055-2076
Publisher: Sage
DOI: 10.1177/2055207618804927

A collaborative platform for Management of Chronic Diseases via guideline-driven individualized care plans

Author(s): Gokce B. Laleci Erturkmen, Mustafa Yuksel, Bunyamin Sarigul, Theodoros N. Arvanitis, Pontus Lindman, Rong Chen, Lei Zhao, Eric Sadou, Jacques Bouaud, Lamine Traore, Alper Teoman, Sarah N. Lim Choi Keung, George Despotou, Esteban de Manuel, Dolores Verdoy, Antonio de Blas, Nicolas Gonzalez, Mikael Liljaj, Malte von Tottleben, Marie Beach, Christopher Marguerie, Gunnar O. Klein, Dipak Kalra
Published in: Computational and Structural Biotechnology Journal, Issue Available online 12 June 2019, 2019, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2019.06.003

Abstract no. 56 C3-Cloud: a federated collaborative care and cure cloud architecture for addressing the needs of multi-morbidity and managing poly-pharmacy

Author(s): Gökce Banu Laleci Erturkmen, Mustafa Yuksel, Theodoros Arvanitis
Published in: BMJ Health & Care Informatics, Issue 24(3), 2017, Page(s) Abstract 56, ISSN 2632-1009
Publisher: BMJ

C3-Cloud personalised care plan development platform for addressing the needs of multi-morbidity and managing poly-pharmacy: Protocol for a pilot technology trial (Pre-print)

Author(s): M. Von Tottleben, K. Grinyer, A. Arfa, L. Traore, D. Verdoy, S. N. Lim Choi Keung, I. Larrañaga Uribetxebarria, M-C. Jaulent, E. De Manuel Keenoy, M. Lilja, M. Beach, C. Marguerie, M. Yuksel, G. B. Laleci Ertukmen, G. O. Klein, P. Lindman, Javier Mar, D. Kalra, T. N. Arvanitis (on behalf of the C3-Cloud Consortium)
Published in: JMIR Research Protocols, 2020, ISSN 1929-0748
Publisher: JMIR Publications
DOI: 10.2196/preprints.21994

E-health for active ageing; A systematic review

Author(s): Timothy David Robbins, Sarah N. Lim Choi Keung, Theodoros N. Arvanitis
Published in: Maturitas, Issue 114, 2018, Page(s) 34-40, ISSN 0378-5122
Publisher: Elsevier BV
DOI: 10.1016/j.maturitas.2018.05.008

Structuring Clinical Decision Support Rules for Drug Safety Using Natural Language Processing

Author(s): George Despotou, Ioannis Korkontzelos, Nicholas Matragkas, Eda Bilici, Theodoros N. Arvanitis
Published in: Studies in Health Technology and Informatics, Issue 251, 2018, Page(s) 89 - 92, ISSN 1879-8365
Publisher: IOS Press
DOI: 10.3233/978-1-61499-880-8-89

Evaluating data across care boundaries: integrated care in the context of multi-morbidity

Author(s): Timothy Robbins, Sarah N. Lim Choi Keung, Sailesh Sankaranarayanan, Harpal Randeva, Theodoros N. Arvanitis
Published in: International Journal of Integrated Care, Issue 19/4, 2019, Page(s) 3, ISSN 1568-4156
Publisher: Igitur, Utrecht Publishing and Archiving Services
DOI: 10.5334/ijic.s3003

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