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Pathogen and Graphene

Livrables

Newsletter 1

Newletter 1 written up

pathogen-host interaction

Knowledge of how and if these pathogen interact with host surfaces

Newsletter 3

Newsletter 3 written up

switch

Results on the possibility to switch antibacterial character

Dissemination Activities Final

Final Report on Dissemination Activities

Final Report Protocol for the synthesis of various ligands for modulating glycan-protein interactions

Protocol for the synthesis of various ligands for modulating glycan-protein interactions

Menthol

Protocol for the chemical integration of menthol and antibacterial peptides

photothermal-photodynamic

Protocol for the formulation of photothermal-photodynamic rGO

Immune response

Protocol for the functions and immune response

Dissemination

First Report on Dissemination Activities

Project start up

get everybody started

Newsletter 4

Newsletter 4 written up

Newsletter

Newsletter 2 written up

bacteriocidal effect

Results on bacteriocidal effect of Graphene interfaces

nzyme-linked lectinosorbent assay

Protocol for the testing of bacterial antagonists with Enzyme-linked lectinosorbent assay

chemically modified rGO nanoparticles

Results on antibacterial properties of chemically modified rGO nanoparticles together with their formulation

Effect on Macrophage

Protocol for the testing of synthesized compounds on their effect on macrophage.

SPR analysis

Results of SPR analysis under static and flow conditions

Publications

Flexible Nanoholey Patches for Antibiotic-Free Treatments of Skin Infections

Auteurs: Chengnan Li, Ran Ye, Julie Bouckaert, Amaia Zurutuza, Djamel Drider, Tetiana Dumych, Solomiya Paryzhak, Volodymyr Vovk, Rostyslav O. Bilyy, Sorin Melinte, Musen Li, Rabah Boukherroub, Sabine Szunerits
Publié dans: ACS Applied Materials & Interfaces, Issue 9/42, 2017, Page(s) 36665-36674, ISSN 1944-8244
DOI: 10.1021/acsami.7b12949

On demand electrochemical release of drugs from porous reduced graphene oxide modified flexible electrodes

Auteurs: Samia Boulahneche, Roxana Jijie, Alexandre Barras, Fereshteh Chekin, Santosh K. Singh, Julie Bouckaert, Mohamed Salah Medjram, Sreekumar Kurungot, Rabah Boukherroub, Sabine Szunerits
Publié dans: J. Mater. Chem. B, Issue 5/32, 2017, Page(s) 6557-6565, ISSN 2050-7518
DOI: 10.1039/c7tb00687j

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

Auteurs: Roxana Jijie, Alexandre Barras, Florina Teodorescu, Rabah Boukherroub, Sabine Szunerits
Publié dans: Mol. Syst. Des. Eng., Issue 2/4, 2017, Page(s) 349-369, ISSN 2058-9689
DOI: 10.1039/c7me00048k

Selective isolation and eradication of E. coli associated with urinary tract infections using anti-fimbrial modified magnetic reduced graphene oxide nanoheaters

Auteurs: Fatima Halouane, Roxana Jijie, Dalila Meziane, Chengnan Li, Santosh K. Singh, Julie Bouckaert, Jean Jurazek, Sreekumar Kurungot, Alexandre Barras, Musen Li, Rabah Boukherroub, Sabine Szunerits
Publié dans: J. Mater. Chem. B, Issue 5/40, 2017, Page(s) 8133-8142, ISSN 2050-7518
DOI: 10.1039/c7tb01890h

Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors

Auteurs: Jin Chen, Ricardo A. Chaurio, Christian Maueröder, Anja Derer, Manfred Rauh, Andriy Kost, Yi Liu, Xianming Mo, Axel Hueber, Rostyslav Bilyy, Martin Herrmann, Yi Zhao, Luis E. Muñoz
Publié dans: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
DOI: 10.3389/fimmu.2017.00504

Neutrophil Extracellular Traps Open the Pandora’s Box in Severe Malaria

Auteurs: Sebastian Boeltz, Luis E. Muñoz, Tobias A. Fuchs, Martin Herrmann
Publié dans: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
DOI: 10.3389/fimmu.2017.00874

Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation

Auteurs: Mona H. C. Biermann, Malgorzata J. Podolska, Jasmin Knopf, Christiane Reinwald, Daniela Weidner, Christian Maueröder, Jonas Hahn, Deborah Kienhöfer, Alexandre Barras, Rabah Boukherroub, Sabine Szunerits, Rostyslav Bilyy, Markus Hoffmann, Yi Zhao, Georg Schett, Martin Herrmann, Luis E. Munoz
Publié dans: Frontiers in Immunology, Issue 7, 2016, ISSN 1664-3224
DOI: 10.3389/fimmu.2016.00557

Photothermally triggered on-demand insulin release from reduced graphene oxide modified hydrogels

Auteurs: Florina Teodorescu, Yavuz Oz, Gurvan Quéniat, Amar Abderrahmani, Catherine Foulon, Marie Lecoeur, Rana Sanyal, Amitav Sanyal, Rabah Boukherroub, Sabine Szunerits
Publié dans: Journal of Controlled Release, Issue 246, 2017, Page(s) 164-173, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2016.10.028

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Auteurs: Luis E. Muñoz, Rostyslav Bilyy, Mona H. C. Biermann, Deborah Kienhöfer, Christian Maueröder, Jonas Hahn, Jan M. Brauner, Daniela Weidner, Jin Chen, Marina Scharin-Mehlmann, Christina Janko, Ralf P. Friedrich, Dirk Mielenz, Tetiana Dumych, Maxim D. Lootsik, Christine Schauer, Georg Schett, Markus Hoffmann, Yi Zhao, Martin Herrmann
Publié dans: Proceedings of the National Academy of Sciences, Issue 113/40, 2016, Page(s) E5856-E5865, ISSN 0027-8424
DOI: 10.1073/pnas.1602230113

Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs

Auteurs: Christian Maueröder, Aparna Mahajan, Susanne Paulus, Stefanie Gößwein, Jonas Hahn, Deborah Kienhöfer, Mona H. Biermann, Philipp Tripal, Ralf P. Friedrich, Luis E. Munoz, Markus F. Neurath, Christoph Becker, Georg Andreas Schett, Martin Herrmann, Moritz Leppkes
Publié dans: Frontiers in Immunology, Issue 7, 2016, ISSN 1664-3224
DOI: 10.3389/fimmu.2016.00583

Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin

Auteurs: Florina Teodorescu, Gurvan Quéniat, Catherine Foulon, Marie Lecoeur, Alexandre Barras, Samia Boulahneche, Mohmaed Salah Medjram, Thomas Hubert, Amar Abderrahmani, Rabah Boukherroub, Sabine Szunerits
Publié dans: Journal of Controlled Release, Issue 245, 2017, Page(s) 137-146, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2016.11.029

Elevated Serum Lysophosphatidylcholine in Patients with Systemic Lupus Erythematosus Impairs Phagocytosis of Necrotic Cells In Vitro

Auteurs: Gerhard E. Grossmayer, Hildegard Keppeler, Sebastian Boeltz, Christina Janko, Jürgen Rech, Martin Herrmann, Kirsten Lauber, Luis E. Muñoz
Publié dans: Frontiers in Immunology, Issue 8, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2017.01876

Oligomannose-Rich Membranes of Dying Intestinal Epithelial Cells Promote Host Colonization by Adherent-Invasive E. coli

Auteurs: Tetiana Dumych, Nao Yamakawa, Adeline Sivignon, Estelle Garenaux, Stefania Robakiewicz, Bernadette Coddeville, Antonino Bongiovanni, Fabrice Bray, Nicolas Barnich, Sabine Szunerits, Christian Slomianny, Martin Herrmann, Sébastien G. Gouin, Alexander D. Lutsyk, Luis E. Munoz, Frank Lafont, Christian Rolando, Rostyslav Bilyy, Julie M. J. Bouckaert
Publié dans: Frontiers in Microbiology, Issue 9, 2018, ISSN 1664-302X
DOI: 10.3389/fmicb.2018.00742

Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery

Auteurs: Sabine Szunerits, Rabah Boukherroub
Publié dans: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
DOI: 10.3389/fbioe.2018.00015

Missing in action-The meaning of cell death in tissue damage and inflammation

Auteurs: Luis E. Muñoz, Moritz Leppkes, Tobias A. Fuchs, Markus Hoffmann, Martin Herrmann
Publié dans: Immunological Reviews, Issue 280/1, 2017, Page(s) 26-40, ISSN 0105-2896
DOI: 10.1111/imr.12569

Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG

Auteurs: Jasmin Knopf, Iryna Magorivska, Juan M. Maler, Philipp Spitzer, Rostyslav Bilyy, Mona H.C. Biermann, Kateryna Hychka, Albert Bondt, Manfred Wuhrer, Rene E.M. Toes, Georg Schett, Martin Herrmann, Luis E. Muñoz
Publié dans: Journal of Neuroimmunology, Issue 320, 2018, Page(s) 19-24, ISSN 0165-5728
DOI: 10.1016/j.jneuroim.2018.04.010

Altered glycan accessibility on native immunoglobulin G complexes in early rheumatoid arthritis and its changes during therapy

Auteurs: J. Stümer, M. H. C. Biermann, J. Knopf, I. Magorivska, A. Kastbom, A. Svärd, C. Janko, R. Bilyy, G. Schett, C. Sjöwall, M. Herrmann, L. E. Muñoz
Publié dans: Clinical & Experimental Immunology, Issue 189/3, 2017, Page(s) 372-382, ISSN 0009-9104
DOI: 10.1111/cei.12987

Reduced Graphene-Oxide-Embedded Polymeric Nanofiber Mats: An “On-Demand” Photothermally Triggered Antibiotic Release Platform

Auteurs: Ismail Altinbasak, Roxana Jijie, Alexandre Barras, Bianka Golba, Rana Sanyal, Julie Bouckaert, Djamel Drider, Rostyslav Bilyy, Tetiana Dumych, Solomiya Paryzhak, Volodymyr Vovk, Rabah Boukherroub, Amitav Sanyal, Sabine Szunerits
Publié dans: ACS Applied Materials & Interfaces, Issue 10/48, 2018, Page(s) 41098-41106, ISSN 1944-8244
DOI: 10.1021/acsami.8b14784

Improved photodynamic effect through encapsulation of two photosensitizers in lipid nanocapsules

Auteurs: Alexandre Barras, Nadia Skandrani, Mariano Gonzalez Pisfil, Solomiya Paryzhak, Tetiana Dumych, Aurélien Haustrate, Laurent Héliot, Tijani Gharbi, Hatem Boulahdour, V'yacheslav Lehen’kyi, Rostyslav Bilyy, Sabine Szunerits, Gabriel Bidaux, Rabah Boukherroub
Publié dans: Journal of Materials Chemistry B, Issue 6/37, 2018, Page(s) 5949-5963, ISSN 2050-7518
DOI: 10.1039/c8tb01759j

Antibacterial activity of graphene-based materials

Auteurs: Sabine Szunerits, Rabah Boukherroub
Publié dans: Journal of Materials Chemistry B, Issue 4/43, 2016, Page(s) 6892-6912, ISSN 2050-7518
DOI: 10.1039/c6tb01647b

Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites

Auteurs: Kostiantyn Turcheniuk, Tetiana Dumych, Rostyslav Bilyy, Volodymyr Turcheniuk, Julie Bouckaert, Volodymyr Vovk, Valentyna Chopyak, Vladimir Zaitsev, Pascal Mariot, Natasha Prevarskaya, Rabah Boukherroub, Sabine Szunerits
Publié dans: RSC Advances, Issue 6/2, 2016, Page(s) 1600-1610, ISSN 2046-2069
DOI: 10.1039/c5ra24662h

Functionalization of Reduced Graphene Oxide via Thiol–Maleimide “Click” Chemistry: Facile Fabrication of Targeted Drug Delivery Vehicles

Auteurs: Yavuz Oz, Alexandre Barras, Rana Sanyal, Rabah Boukherroub, Sabine Szunerits, Amitav Sanyal
Publié dans: ACS Applied Materials & Interfaces, Issue 9/39, 2017, Page(s) 34194-34203, ISSN 1944-8244
DOI: 10.1021/acsami.7b08433

Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus

Auteurs: Mona H. C. Biermann, Sebastian Boeltz, Elmar Pieterse, Jasmin Knopf, Jürgen Rech, Rostyslav Bilyy, Johan van der Vlag, Angela Tincani, Jörg H. W. Distler, Gerhard Krönke, Georg Andreas Schett, Martin Herrmann, Luis E. Muñoz
Publié dans: Frontiers in Immunology, Issue 9, 2018, Page(s) 989, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.00989

Repeated photoporation with graphene quantum dots enables homogeneous labeling of live cells with extrinsic markers for fluorescence microscopy

Auteurs: Jing Liu, Ranhua Xiong, Toon Brans, Saskia Lippens, Eef Parthoens, Francesca Cella Zanacchi, Raffaella Magrassi, Santosh K. Singh, Sreekumar Kurungot, Sabine Szunerits, Hannelore Bové, Marcel Ameloot, Juan C. Fraire, Eline Teirlinck, Sangram Keshari Samal, Riet De Rycke, Gaëlle Houthaeve, Stefaan C. De Smedt, Rabah Boukherroub, Kevin Braeckmans
Publié dans: Light: Science & Applications, Issue 7/1, 2018, ISSN 2047-7538
DOI: 10.1038/s41377-018-0048-3

A Novel Integrated Way for Deciphering the Glycan Code for the FimH Lectin

Auteurs: Tetiana Dumych, Clarisse Bridot, Sébastien Gouin, Marc Lensink, Solomiya Paryzhak, Sabine Szunerits, Ralf Blossey, Rostyslav Bilyy, Julie Bouckaert, Eva-Maria Krammer
Publié dans: Molecules, Issue 23/11, 2018, Page(s) 2794, ISSN 1420-3049
DOI: 10.3390/molecules23112794

Aluminum oxide nanowires as safe and effective adjuvants for next-generation vaccines

Auteurs: Rostyslav Bilyy, Solomiya Paryzhak, Kostiantyn Turcheniuk, Tetiana Dumych, Alexandre Barras, Rabah Boukherroub, Fujia Wang, Gleb Yushin, Sabine Szunerits
Publié dans: Materials Today, Issue 22, 2019, Page(s) 58-66, ISSN 1369-7021
DOI: 10.1016/j.mattod.2018.10.034

Differentiation of Crohn’s Disease-Associated Isolates from Other Pathogenic Escherichia coli by Fimbrial Adhesion under Shear Force

Auteurs: Sabine Szunerits, Oleksandr Zagorodko, Virginie Cogez, Tetiana Dumych, Thibaut Chalopin, Dimitri Alvarez Dorta, Adeline Sivignon, Nicolas Barnich, Anne Harduin-Lepers, Iban Larroulet, Aritz Yanguas Serrano, Aloysius Siriwardena, Amaia Pesquera, Amaia Zurutuza, Sébastien Gouin, Rabah Boukherroub, Julie Bouckaert
Publié dans: Biology, Issue 5/2, 2016, Page(s) 14, ISSN 2079-7737
DOI: 10.3390/biology5020014

Affinity of Glycan-Modified Nanodiamonds towards Lectins and Uropathogenic Escherichia Coli

Auteurs: Volodymyr Turcheniu, Kostiantyn Turcheniuk, Julie Bouckaert, Alexandre Barras, Tetiana Dumych, Rostyslav Bilyy, Vladimir Zaitsev, Aloysius Siriwardena, Qi Wang, Rabah Boukherroub, Sabine Szunerits
Publié dans: ChemNanoMat, Issue 2, 2016, Page(s) 307-314, ISSN 1520-5215
DOI: 10.1002/cnma.201500229

Graphene-based nanomaterials in innovative electrochemistry

Auteurs: Sabine Szunerits, Rabah Boukherroub
Publié dans: Current Opinion in Electrochemistry, Issue 10, 2018, Page(s) 24-30, ISSN 2451-9103
DOI: 10.1016/j.coelec.2018.03.016

Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects

Auteurs: Roxana Jijie, Alexandre Barras, Julie Bouckaert, Nicoleta Dumitrascu, Sabine Szunerits, Rabah Boukherroub
Publié dans: Colloids and Surfaces B: Biointerfaces, Issue 170, 2018, Page(s) 347-354, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2018.06.040

Aqueous medium-induced micropore formation in plasma polymerized polystyrene: an effective route to inhibit bacteria adhesion

Auteurs: Roxana Jijie, Alexandre Barras, Teodora Teslaru, Ionut Topala, Valentin Pohoata, Marius Dobromir, Tetiana Dumych, Julie Bouckaert, Sabine Szunerits, Nicoleta Dumitrascu, Rabah Boukherroub
Publié dans: Journal of Materials Chemistry B, Issue 6/22, 2018, Page(s) 3674-3683, ISSN 2050-7518
DOI: 10.1039/c7tb02964k

Nanomaterials for transdermal drug delivery: beyond the state of the art of liposomal structures

Auteurs: Roxana Jijie, Alexandre Barras, Rabah Boukherroub, Sabine Szunerits
Publié dans: Journal of Materials Chemistry B, Issue 5/44, 2017, Page(s) 8653-8675, ISSN 2050-7518
DOI: 10.1039/C7TB02529G

Nucleic aptamer modified porous reduced graphene oxide/MoS2 based electrodes for viral detection: Application to human papillomavirus (HPV)

Auteurs: Fereshteh Chekin, Komal Bagga, Palaniappan Subramanian, Roxana Jijie, Santosh K. Singh, Sreekumar Kurungot, Rabah Boukherroub, Sabine Szunerits
Publié dans: Sensors and Actuators B: Chemical, Issue 262, 2018, Page(s) 991-1000, ISSN 0925-4005
DOI: 10.1016/j.snb.2018.02.065

Graphene-based biosensors

Auteurs: Sabine Szunerits, Rabah Boukherroub
Publié dans: Interface Focus, Issue 8/3, 2018, Page(s) 20160132, ISSN 2042-8898
DOI: 10.1098/rsfs.2016.0132

Electrochemical Methodologies for the Detection of Pathogens

Auteurs: Mandana Amiri, Abolfazl Bezaatpour, Hamed Jafari, Rabah Boukherroub, Sabine Szunerits
Publié dans: ACS Sensors, Issue 3/6, 2018, Page(s) 1069-1086, ISSN 2379-3694
DOI: 10.1021/acssensors.8b00239

Graphene-based bioelectrochemistry and bioelectronics: A concept for the future?

Auteurs: Sabine Szunerits, Rabah Boukherroub
Publié dans: Current Opinion in Electrochemistry, Issue 12, 2018, Page(s) 141-147, ISSN 2451-9103
DOI: 10.1016/j.coelec.2018.03.028