Periodic Reporting for period 2 - CARTHER (Carbon-based nano-materials for theranostic application)
Période du rapport: 2018-01-01 au 2019-12-31
1) Carbon fluoroxide nanoparticles originally synthesized by researches from INSA Lyon and nanodiamonds with specific surface chemistry developped by Ray Techniques company have been found to be the most efficient for incorporation into living cells.
2) An original experimental set-up for multi-modal (optical, photo-electric and photo-acoustic) bio-imaging purpose has been co-developped by researches from INSA Lyon and Science Park.
3) New and original method and system has been developed by researchers from RT & Aston U for industrial manufacturing of nanodiamond powder.
Major obtained results:
Combination of the nanoparticle injection and the irradiation of tumors with a pulse laser results in increase of mice survival at 50% level from 27 to 38 days. Because the laser-induced localized heating of mice skin has never exceeded 2°C throughout the entire time of treatment, the main mechanism responsible for the observed therapeutic effect can be related to a photo-acoustically induced destruction of cancer cells significantly enhanced by presence of the incorporated carbon nanoparticles.
Potential impact:
Cancer represents the second most important cause of death and morbidity in Europe. The multi-disciplinary researches epitomized in frames of our project is one of the European opportunities to catalyze scientific developments around nanotechnologies devoted to cancer treatment. Physicists, chemists and biologists from university and industrial sectors are teaming up in frame of this proposal to try to attack the cancer malignancies using original bio-functionalized carbon nanomaterials. The outcome of the project will represent new possible photo-induced cancer therapy approaches based on carbon nanomaterials. Market survey indicates that a big market opportunity for the bio-medical applications of the carbon-based nanomaterials remains open. European/International companies will benefit from the technologies developed within the CARTHER proposal due to the novel nanomaterials, especially nanodiamonds and carbon fluoroxide nanoparticles. The proposed novel cancer therapy strategies have a considerable potential for reducing the direct and indirect healthcare costs and increasing cancer therapy efficiency. Profit could result through the “economy” generated by an earlier diagnosis of disease relapse and treatment. If our carbon nanomaterials prove to have a higher efficacy in comparison with the current standard-of-care, a new market product will be clearly foreseeable.