PRoteome-based assessment of vascular disease for the Establishment of a Translational REsearch plATform

Informations projet

PRETREAT

N° de convention de subvention: 690966

DOI

10.3030/690966

Projet clôturé le 1 Mars 2017

Date de signature de la CE 13 Octobre 2015

Date de début 1 Janvier 2016

Date de fin 31 Decembre 2019

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 387 000,00

Contribution de l’UE

€ 387 000,00

Coordonné par

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Periodic Reporting for period 1 - PRETREAT (PRoteome-based assessment of vascular disease for the Establishment of a Translational REsearch plATform)

Période du rapport: 2016-01-01 au 2017-12-31

Résumé du contexte et des objectifs généraux du projet

Cardiovascular diseases are number one cause of death globally, with mortality rates higher than any other non-communicable disease. Vascular disease affects blood (arteries and veins) and lymph vessels of the circulatory system. Many factors, mostly associated to lifestyle (such as smoking, unhealthy diet, lack of exercise, stress etc) and/or having diabetes, being male and having high cholesterol levels favor the development of vascular disease. An active, healthy lifestyle is thus a first step towards improvement of vascular health.
Specific drugs have been developed to reduce vascular disease if adherence to a healthy lifestyle is low or is without effect. These include antihypertensives (lowering blood pressure drugs); antidyslipidemics (lipid lowering drugs) and antithrombotics (anti blood clotting drugs). However these drugs can be much improved upon and that is where the PRETREAT project comes in:
- PRETREAT aimed the identification of early non-invasive (blood and urine) makers of vascular disease so that intervention can be performed at a much earlier stage and hence be more effective and less aggressive (less side-effects).
- PRETREAT also aimed to better understand vascular disease by studying it on the very detailed (molecular) level using modern tools such as proteomics (analysis of all proteins that are modified in disease) and thereby proposing new drug targets.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

The PRETREAT project so far has laid the groundwork for the project by collection of human blood samples, the selection of urinary protein-based markers of vascular disease and development of informatics tools to analyse complex molecular data.
However the partners had to reluctantly terminate the PRETREAT project after 15 months mostly due to the complicated funding scheme of the H2020 RISE action.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

Although the project was terminated after 15 months, it has contributed to the transfer of important know-how on animal handling and specialized bioinformatics tools between partners, increasing both the individual knowledge and skills and consequently the home laboratory knowledge on these issues expected to impact its future research activities. In addition, the generated tool for automated ortholog analysis is versatile and as such, expected to be used for assessment of orthology outside the PRETREAT project.