Peptidomimetics with photocontrolled biological activity

Project Information

PELICO

Grant agreement ID: 690973

DOI 10.3030/690973

Project closed

EC signature date 9 December 2015

Start date 1 January 2016

End date 31 December 2019

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 688 500,00

EU contribution € 688 500,00

Coordinated by

ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE
Ukraine

Deliverables

Other (1)

Novel photocontrollable building blocks

Novel photocontrollable building blocks (in the amount 100-1000 mg), with full characterization data

Websites, patent fillings, videos etc. (1)

Project web-site

Web-site reflecting the essence and non-confidential current results of the work under the Project

Documents, reports (5)

manuscript 4

manuscript of paper based on the obtained results (on novel “molecular photoswitches”)

Manuscript 1

Manuscript draft to be submitted to a peer-reviewed scientific journal containing the results of the in vivo studies which will be considered not confidential

Reports on biological activity studies

Reports on biological activity studies of the novel peptidomimetics

Manuscript 2

Manuscripts of papers based on the obtained results on the lead optimization

Manuscript 3

Manuscripts of a paper based on the obtained results (novel stapled peptidomimetics)

Publications

Peer reviewed articles (6)

Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers

Author(s): Oleg Babii, Sergii Afonin, Tim Schober, Igor V. Komarov, Anne S. Ulrich
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1859/12, 2017, Page(s) 2505-2515, ISSN 0005-2736
Publisher: Elsevier BV
DOI: 10.1016/j.bbamem.2017.09.021

Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking

Author(s): Alexander V. Strizhak, Krishna Sharma, Oleg Babii, Sergii Afonin, Anne S. Ulrich, Igor V. Komarov, David R. Spring
Published in: Organic & Biomolecular Chemistry, 2018, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ob02428f

Structure–Activity Relationships of Photoswitchable Diarylethene-Based β-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents

Author(s): Oleg Babii, Sergii Afonin, Aleksandr Yu. Ishchenko, Tim Schober, Anatoliy O. Negelia, Ganna M. Tolstanova, Liudmyla V. Garmanchuk, Liudmyla I. Ostapchenko, Igor V. Komarov, Anne S. Ulrich
Published in: Journal of Medicinal Chemistry, Issue 61/23, 2018, Page(s) 10793-10813, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.8b01428

Controlling the Uptake of Diarylethene‐Based Cell‐Penetrating Peptides into Cells Using Light

Author(s): Tim Schober, Ilona Wehl, Sergii Afonin, Oleg Babii, Anna Iampolska, Ute Schepers, Igor V. Komarov, Anne S. Ulrich
Published in: ChemPhotoChem, 2019, ISSN 2367-0932
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/cptc.201900019

Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

Author(s): Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe Strähle, Igor V Komarov, Anne S Ulrich
Published in: Beilstein Journal of Organic Chemistry, Issue 16, 2020, Page(s) 39-49, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.16.6

Peptide drugs for photopharmacology: how much of a safety advantage can be gained by photocontrol?

Author(s): Oleg Babii, Sergii Afonin, Tim Schober, Liudmyla V Garmanchuk, Liudmyla I Ostapchenko, Volodymyr Yurchenko, Sergey Zozulya, Oleksandr Tarasov, Iryna Pishel, Anne S Ulrich, Igor V Komarov
Published in: Future Drug Discovery, 2020, ISSN 2631-3316
Publisher: Future Science
DOI: 10.4155/fdd-2019-0033