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Peptidomimetics with photocontrolled biological activity

Deliverables

Novel photocontrollable building blocks

Novel photocontrollable building blocks (in the amount 100-1000 mg), with full characterization data

Project web-site

Web-site reflecting the essence and non-confidential current results of the work under the Project

manuscript 4

manuscript of paper based on the obtained results (on novel “molecular photoswitches”)

Manuscript 1

Manuscript draft to be submitted to a peer-reviewed scientific journal containing the results of the in vivo studies which will be considered not confidential

Reports on biological activity studies

Reports on biological activity studies of the novel peptidomimetics

Manuscript 2

Manuscripts of papers based on the obtained results on the lead optimization

Manuscript 3

Manuscripts of a paper based on the obtained results (novel stapled peptidomimetics)

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Publications

Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers

Author(s): Oleg Babii, Sergii Afonin, Tim Schober, Igor V. Komarov, Anne S. Ulrich
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1859/12, 2017, Page(s) 2505-2515, ISSN 0005-2736
DOI: 10.1016/j.bbamem.2017.09.021

Structure–Activity Relationships of Photoswitchable Diarylethene-Based β-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents

Author(s): Oleg Babii, Sergii Afonin, Aleksandr Yu. Ishchenko, Tim Schober, Anatoliy O. Negelia, Ganna M. Tolstanova, Liudmyla V. Garmanchuk, Liudmyla I. Ostapchenko, Igor V. Komarov, Anne S. Ulrich
Published in: Journal of Medicinal Chemistry, Issue 61/23, 2018, Page(s) 10793-10813, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.8b01428

Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

Author(s): Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe Strähle, Igor V Komarov, Anne S Ulrich
Published in: Beilstein Journal of Organic Chemistry, Issue 16, 2020, Page(s) 39-49, ISSN 1860-5397
DOI: 10.3762/bjoc.16.6

Peptide drugs for photopharmacology: how much of a safety advantage can be gained by photocontrol?

Author(s): Oleg Babii, Sergii Afonin, Tim Schober, Liudmyla V Garmanchuk, Liudmyla I Ostapchenko, Volodymyr Yurchenko, Sergey Zozulya, Oleksandr Tarasov, Iryna Pishel, Anne S Ulrich, Igor V Komarov
Published in: Future Drug Discovery, 2020, ISSN 2631-3316
DOI: 10.4155/fdd-2019-0033