Peptidomimetics with photocontrolled biological activity

Livrables

Novel photocontrollable building blocks (in the amount 100-1000 mg), with full characterization data

Web-site reflecting the essence and non-confidential current results of the work under the Project

manuscript of paper based on the obtained results (on novel “molecular photoswitches”)

Manuscript draft to be submitted to a peer-reviewed scientific journal containing the results of the in vivo studies which will be considered not confidential

Reports on biological activity studies

Reports on biological activity studies of the novel peptidomimetics

Manuscript 2

Manuscripts of papers based on the obtained results on the lead optimization

Manuscript 3

Manuscripts of a paper based on the obtained results (novel stapled peptidomimetics)

Publications

Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers

Auteurs: Oleg Babii, Sergii Afonin, Tim Schober, Igor V. Komarov, Anne S. Ulrich
Publié dans: Biochimica et Biophysica Acta (BBA) - Biomembranes, Numéro 1859/12, 2017, Page(s) 2505-2515, ISSN 0005-2736
Éditeur: Elsevier BV
DOI: 10.1016/j.bbamem.2017.09.021

Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking

Auteurs: Alexander V. Strizhak, Krishna Sharma, Oleg Babii, Sergii Afonin, Anne S. Ulrich, Igor V. Komarov, David R. Spring
Publié dans: Organic & Biomolecular Chemistry, 2018, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8ob02428f

Structure–Activity Relationships of Photoswitchable Diarylethene-Based β-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents

Auteurs: Oleg Babii, Sergii Afonin, Aleksandr Yu. Ishchenko, Tim Schober, Anatoliy O. Negelia, Ganna M. Tolstanova, Liudmyla V. Garmanchuk, Liudmyla I. Ostapchenko, Igor V. Komarov, Anne S. Ulrich
Publié dans: Journal of Medicinal Chemistry, Numéro 61/23, 2018, Page(s) 10793-10813, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.8b01428

Controlling the Uptake of Diarylethene‐Based Cell‐Penetrating Peptides into Cells Using Light

Auteurs: Tim Schober, Ilona Wehl, Sergii Afonin, Oleg Babii, Anna Iampolska, Ute Schepers, Igor V. Komarov, Anne S. Ulrich
Publié dans: ChemPhotoChem, 2019, ISSN 2367-0932
Éditeur: Wiley-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/cptc.201900019

Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

Auteurs: Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe Strähle, Igor V Komarov, Anne S Ulrich
Publié dans: Beilstein Journal of Organic Chemistry, Numéro 16, 2020, Page(s) 39-49, ISSN 1860-5397
Éditeur: Beilstein-Institut
DOI: 10.3762/bjoc.16.6

Peptide drugs for photopharmacology: how much of a safety advantage can be gained by photocontrol?

Auteurs: Oleg Babii, Sergii Afonin, Tim Schober, Liudmyla V Garmanchuk, Liudmyla I Ostapchenko, Volodymyr Yurchenko, Sergey Zozulya, Oleksandr Tarasov, Iryna Pishel, Anne S Ulrich, Igor V Komarov
Publié dans: Future Drug Discovery, 2020, ISSN 2631-3316
Éditeur: Future Science
DOI: 10.4155/fdd-2019-0033

Livrables

Publications

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