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Mastiha treatment for healthy obese with NAFLD diagnosis (MAST4HEALTH).

Objective

MAST4HEALTH is set on the concept of a multidisciplinary approach to assess a non-pharmacological intervention for managing NAFLD/NASH, one of the most common complications of obesity and diabetes mellitus in Western populations affecting approximately 50% of diabetics and 76% of obese patients. Because of limitations in current NAFLD treatment therapies, many new efforts focus on exploring non-pharmacologic means for managing the disease and in particular through dietary substances or bioactive phytochemicals in fruits, vegetables, and plants or their products. MAST4HEALTH aims at exploring the effect of Mastiha, a natural product of Greece which was recently shown to possess antioxidant/anti-inflammatory and lipid lowering properties. We designed a multicenter randomized double blind placebo controlled (parallel arm) clinical trial to test the effectiveness of Mastiha supplement as new non-pharmacologic strategy for NAFLD/NASH treatment. MAST4HEALTH will explore gene-diet interactions, more specifically the potential personalized activity of the Mastiha, and correlate genetic and epigenetic markers with metabolomic and intestinal microbiota profiles pre- and post-intervention. The effectiveness of the proposed intervention will be evaluated via clinical and laboratory markers of the disease. To this end, MAST4HEALTH will train a number of researchers and PhD students in multidisciplinary approaches of this survey. MAST4HEALTH is expected to build and enhance cooperation among partners meanwhile strengthening the interaction between our academic and non-academic sectors

Coordinator

CHAROKOPEIO PANEPISTIMIO
Net EU contribution
€ 441 000,00
Address
Eleftheriou Venizelou 70
176 71 Athina
Greece

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Region
Νότιος Τομέας Αθηνών Aττική Αττική
Activity type
Higher or Secondary Education Establishments
Other funding
€ 441 000,00

Participants (14)

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
Net EU contribution
€ 162 000,00
Address
327 Mile End Road
E1 4NS London

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Region
London Inner London — East Tower Hamlets
Activity type
Higher or Secondary Education Establishments
Other funding
€ 162 000,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 135 000,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 135 000,00
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Net EU contribution
€ 121 500,00
Address
Piazzale Aldo Moro 7
00185 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 121 500,00
FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA
Spain
Net EU contribution
€ 117 000,00
Address
Calle Micer Masco 31
46010 Valencia

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Research Organisations
Other funding
€ 117 000,00
BIOTECH VANA SL
Spain
Net EU contribution
€ 157 500,00
Address
Calle Catedratico Agustin Escardino 9, Edificio 1.17, Vivero Parc Cientific De La Universitat De Valencia
46980 Paterna (Valencia)

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 157 500,00
Randox Laboratories Ltd
United Kingdom
Net EU contribution
€ 153 000,00
Address
Diamond Road 55
BT29 4QY Crumlin

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Region
Northern Ireland Northern Ireland Antrim and Newtownabbey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 153 000,00
MARASCIO FERNANDO
Italy
Net EU contribution
€ 108 000,00
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 108 000,00
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
Net EU contribution
€ 81 000,00
Address
Bruningstrasse 50
65929 Frankfurt Am Main

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 81 000,00
ENOSIS MASTICHOPARAGOGON CHIOU
Greece
Net EU contribution
€ 297 000,00
Address
1 K. Monomachou St
82100 Chios

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Χίος Βόρειο Αιγαίο Νησιά Αιγαίου
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 297 000,00
PERSPECTUM LTD
United Kingdom
Net EU contribution
€ 157 500,00
Address
Gemini One, 5520 John Smith Drive Oxford Business Park South
OX4 2LL Oxford

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 157 500,00
UNIVERZITET U NOVOM SADU MEDICINSKI - FAKULTET SA POTPUNOM ODGOVORNOSCU
Serbia
Net EU contribution
€ 108 000,00
Address
Hajduk Veljkova Street 3
21000 Novi Sad

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Region
Србија - север Регион Војводине Јужнобачка област
Activity type
Higher or Secondary Education Establishments
Other funding
€ 108 000,00
UNIVERZITET U ISTOCNOM SARAJEVU
Bosnia and Herzegovina
Net EU contribution
€ 13 500,00
Address
Vuka Karadzica 30
71123 Istocno Sarajevo

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 13 500,00
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Net EU contribution
€ 63 000,00
Address
Via Festa Del Perdono 7
20122 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Other funding
€ 63 000,00
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Italy
Net EU contribution
€ 9 000,00
Address
Via Francesco Sforza 28
20122 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Other
Other funding
€ 9 000,00