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Molecular Mechanisms of Endometriosis

Objective

Endometriosis (the presence of endometrial-like tissue or ‘lesions’ outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent growth of endometriosis lesions. By combining the respective strengths of non-academic and clinical partners, MOMENDO expect to successfully translate these findings into novel therapeutic approaches.

Call for proposal

H2020-MSCA-RISE-2015
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Address
Schlossplatz 2
48149 Muenster
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 63 000

Participants (6)

THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 40 500
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 81 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 54 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
SEREND-IP GMBH
Germany
EU contribution
€ 13 500
Address
Rostockweg 25
48147 Muenster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AQUILA BIOMEDICAL LIMITED
United Kingdom
EU contribution
€ 0
Address
Nine The Bioquarter
EH16 4UX Edinburgh
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TERVISETEHNOLOOGIATE ARENDUSKESKUS AS
Estonia
EU contribution
€ 94 500
Address
Teaduspargi Tn 13
50411 Tartu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (2)

CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET)
Argentina
Address
Godoy Cruz 2290
C1425FQB Buenos Aires
Activity type
Research Organisations
UNIVERSIDAD DE CHILE
Chile
Address
Av. Libertador Bernardo O'higgins 1058
10 Santiago
Activity type
Higher or Secondary Education Establishments