Periodic Reporting for period 2 - nanoBAT (Enhanced brown adipose tissue activity using nanotechnology approaches)
Reporting period: 2018-02-01 to 2020-01-31
Firstly, the intersectoral and interdisciplinary transfer of knowledge between the Universities and industrial institutions (small companies) involved in the project has been promoted, through the exchange of a total of 8 experience researches and 3 young researchers. The current cooperation has an impact on the personal career of the researchers that have acquired new skills, experiences on different work environment, and they increased their contact network. On the other hand the organization of several workshops has allowed to maximize the transfer of knowledge between the university community and industrial institution that have attended to the workshops.
Secondly, we designed a novel therapy for treatment of obesity and cardio metabolic diseases based on the activation of the brown fat tissue that is responsible for non-shivering thermogenesis upon cold exposure or high fat diet. To reach this goal, the researches have to acquire a deep understanding about brown fat tissue physiological function along different human ages and especially in overweight patients with associated pathologies. These knowledges were essential to define patient targets and the design of the final product depending on the most appropriate administration route and site.
At last, we developed L-menthol encapsulating nanoparticle prototypes and assessed their permeability and cell toxicity.
At the end of the project, we hope to have developed a product that can be considered as a food supplement and that will increase the human metabolic rate. After the necessary validation studies, the product can be used as a tool in the fight against obesity.