TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease

Deliverables

Working paper for management of the comprehensive clinical PD centre

Working paper for management of the comprehensive clinical PD centre This paper will be drafted as a result of the day workshop, then be commented by the participants and finalised by the SC

Evaluation procedures

Evaluation procedures This deliverable will outline the procedures for self-evaluation of the newly established centre taking into account input and output, institutional constituency as well as innovation capacity in terms of health and economic impacts.

Standardised protocols for iPSC-based models (reprogramming, maintenance, gene editing)
Common neuro-imaging platform multivariate feature discovery in PD
Definition of criteria for the recruitment of an at-risk-cohort in Luxembourg
Comprehensive awareness programme plan
Research and Industrial collaborations established
Ethical approval for brain banking in Luxembourg

ethical approval for brain banking in Luxembourg

Movement disorders curriculum

Movement disorders curriculum Detailed curriculum outlining the knowledge transfer with regards to Movement disorders

Implementation of a gait laboratory using telemetric assessments in Luxembourg

Implementation of a gait laboratory using telemetric assessments in Luxembourg Documents outlining the establishment of such an infrastructure

Website/Intranet

Website/Intranet screenshots of website/intranet and description of the portal

Publications

An Observational Study of the Effect of Levodopa–Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson’s Disease Patients

Author(s): Rejko Krüger, Paul Lingor, Triantafyllos Doskas, Johanna M. L. Henselmans, Erik H. Danielsen, Oriol de Fabregues, Alessandro Stefani, Sven-Christian Sensken, Juan Carlos Parra, Koray Onuk, Ashley Yegin, Angelo Antonini
Published in: Advances in Therapy, Issue 34/7, 2017, Page(s) 1741-1752, ISSN 0741-238X
Publisher: Health Communications, Inc.
DOI: 10.1007/s12325-017-0571-2

Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson’s disease

Author(s): Julia C Fitzgerald, Alexander Zimprich, Daniel A Carvajal Berrio, Kevin M Schindler, Brigitte Maurer, Claudia Schulte, Christine Bus, Anne-Kathrin Hauser, Manuela Kübler, Rahel Lewin, Dheeraj Reddy Bobbili, Lisa M Schwarz, Evangelia Vartholomaiou, Kathrin Brockmann, Richard Wüst, Johannes Madlung, Alfred Nordheim, Olaf Riess, L Miguel Martins, Enrico Glaab, Patrick May, Katja Schenke-Layland, Di
Published in: Brain, Issue 140/9, 2017, Page(s) 2444-2459, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awx202

The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis

Author(s): Geraldine Hipp, Michel Vaillant, Nico J. Diederich, Kirsten Roomp, Venkata P. Satagopam, Peter Banda, Estelle Sandt, Kathleen Mommaerts, Sabine K. Schmitz, Laura Longhino, Alexandra Schweicher, Anne-Marie Hanff, Béatrice Nicolai, Pierre Kolber, Dorothea Reiter, Lukas Pavelka, Sylvia Binck, Claire Pauly, Lars Geffers, Fay Betsou, Manon Gantenbein, Jochen Klucken, Thomas Gasser, Michele T. Hu, Rudi
Published in: Frontiers in Aging Neuroscience, Issue 10, 2018, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2018.00326

The genetic architecture of mitochondrial dysfunction in Parkinson’s disease

Author(s): S. B. Larsen, Z. Hanss, R. Krüger
Published in: Cell and Tissue Research, Issue 373/1, 2018, Page(s) 21-37, ISSN 0302-766X
Publisher: Springer Verlag
DOI: 10.1007/s00441-017-2768-8

Management of Parkinson’s Disease 20 Years from Now: Towards Digital Health Pathways

Author(s): Jochen Klucken, Rejko Krüger, Peter Schmidt, Bastiaan R. Bloem
Published in: Journal of Parkinson's Disease, Issue 8/s1, 2018, Page(s) S85-S94, ISSN 1877-7171
Publisher: IOS Press
DOI: 10.3233/jpd-181519

NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases

Author(s): Cornelis Blauwendraat, Faraz Faghri, Lasse Pihlstrom, Joshua T. Geiger, Alexis Elbaz, Suzanne Lesage, Jean-Christophe Corvol, Patrick May, Aude Nicolas, Yevgeniya Abramzon, Natalie A. Murphy, J. Raphael Gibbs, Mina Ryten, Raffaele Ferrari, Jose Bras, Rita Guerreiro, Julie Williams, Rebecca Sims, Steven Lubbe, Dena G. Hernandez, Kin Y. Mok, Laurie Robak, Roy H. Campbell, Ekaterina Rogaeva, Bryan J.
Published in: Neurobiology of Aging, Issue 57, 2017, Page(s) 247.e9-247.e13, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.05.009

Cortical correlates of susceptibility to upper limb freezing in Parkinson’s disease

Author(s): Marlieke Scholten, Rathinaswamy B. Govindan, Christoph Braun, Bastiaan R. Bloem, Christian Plewnia, Rejko Krüger, Alireza Gharabaghi, Daniel Weiss
Published in: Clinical Neurophysiology, Issue 127/6, 2016, Page(s) 2386-2393, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2016.01.028

Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease

Author(s): Richard Wüst, Brigitte Maurer, Kathrin Hauser, Dirk Woitalla, Manu Sharma, Rejko Krüger
Published in: Neurobiology of Aging, Issue 39, 2016, Page(s) 217.e13-217.e15, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2015.11.025

Classification of advanced stages of Parkinson’s disease: translation into stratified treatments

Author(s): Rejko Krüger, Jochen Klucken, Daniel Weiss, Lars Tönges, Pierre Kolber, Stefan Unterecker, Michael Lorrain, Horst Baas, Thomas Müller, Peter Riederer
Published in: Journal of Neural Transmission, Issue 124/8, 2017, Page(s) 1015-1027, ISSN 0300-9564
Publisher: Springer Verlag
DOI: 10.1007/s00702-017-1707-x

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Author(s): Lisa Wang, Michael G. Heckman, Jan O. Aasly, Grazia Annesi, Maria Bozi, Sun Ju Chung, Carl Clarke, David Crosiers, Gertrud Eckstein, Gaetan Garraux, Georgios M. Hadjigeorgiou, Nobu Hattori, Beom Jeon, Yun J. Kim, Masato Kubo, Suzanne Lesage, Juei Jueng Lin, Timothy Lynch, Peter Lichtner, George D. Mellick, Vincent Mok, Karin E. Morrison, Aldo Quattrone, Wataru Satake, Peter A. Silburn, Leonidas St
Published in: Neurobiology of Aging, Issue 49, 2017, Page(s) 217.e1-217.e4, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2016.09.022

Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies

Author(s): Stefanie Lerche, Sebastian Heinzel, Guido W. Alves, Paolo Barone, Stefanie Behnke, Yoav Ben-Shlomo, Henk Berendse, Bastiaan R. Bloem, David Burn, Richard Dodel, Donald G. Grosset, Geraldine Hipp, Michele T. Hu, Meike Kasten, Rejko Krüger, Inga Liepelt-Scarfone, Walter Maetzler, Marcello Moccia, Brit Mollenhauer, Wolfgang Oertel, Benjamin Roeben, Uwe Walter, Karin Wirdefeldt, Daniela Berg
Published in: Frontiers in Aging Neuroscience, Issue 8, 2016, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2016.00121

Tragbare und aktiv vom Parkinson-Patienten genutzte Technologie im häuslichen Umfeld: Was bringt die Zukunft?

Author(s): W. Maetzler, R. Krüger, T. Müller, W. Oertel, P. Urban, T. Warnecke, J. Klucken
Published in: Fortschritte der Neurologie · Psychiatrie, Issue 84/S 01, 2016, Page(s) S48-S51, ISSN 0720-4299
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0042-102786

Alpha-synuclein gene variants may predict neurostimulation outcome

Author(s): Daniel Weiss, Sonja Herrmann, Lisa Wang, Claudia Schulte, Kathrin Brockmann, Christian Plewnia, Thomas Gasser, Manu Sharma, Alireza Gharabaghi, Rejko Krüger
Published in: Movement Disorders, Issue 31/4, 2016, Page(s) 601-603, ISSN 0885-3185
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mds.26558

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2

Author(s): Nicolas Casadei, Poonam Sood, Thomas Ulrich, Petra Fallier-Becker, Nicole Kieper, Stefan Helling, Caroline May, Enrico Glaab, Jing Chen, Silke Nuber, Katrin Marcus, Doron Rapaport, Thomas Ott, Olaf Riess, Rejko Krüger, Julia C. Fitzgerald
Published in: Human Molecular Genetics, Issue 25/3, 2016, Page(s) 459-471, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddv485

Validation of conversion between mini-mental state examination and montreal cognitive assessment

Author(s): Michael Lawton, Meike Kasten, Margaret T. May, Brit Mollenhauer, Martina Schaumburg, Inga Liepelt-Scarfone, Walter Maetzler, Eva-Juliane Vollstedt, Michele T.M. Hu, Daniela Berg, Yoav Ben-Shlomo
Published in: Movement Disorders, Issue 31/4, 2016, Page(s) 593-596, ISSN 0885-3185
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mds.26498

Prodromal Markers in Parkinson’s Disease: Limitations in Longitudinal Studies and Lessons Learned

Author(s): Sebastian Heinzel, Benjamin Roeben, Yoav Ben-Shlomo, Stefanie Lerche, Guido Alves, Paolo Barone, Stefanie Behnke, Henk W. Berendse, Bastiaan R. Bloem, David Burn, Richard Dodel, Donald G. Grosset, Michele Hu, Meike Kasten, Rejko Krüger, Marcello Moccia, Brit Mollenhauer, Wolfgang Oertel, Ulrike Suenkel, Uwe Walter, Karin Wirdefeldt, Inga Liepelt-Scarfone, Walter Maetzler, Daniela Berg
Published in: Frontiers in Aging Neuroscience, Issue 8, 2016, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2016.00147

Short- and long-term outcome of chronic pallidal neurostimulation in monogenic isolated dystonia

Author(s): N. Bruggemann, A. Kuhn, S. A. Schneider, C. Kamm, A. Wolters, P. Krause, E. Moro, F. Steigerwald, M. Wittstock, V. Tronnier, A. M. Lozano, C. Hamani, Y.-Y. Poon, S. Zittel, T. Wachter, G. Deuschl, R. Kruger, A. Kupsch, A. Munchau, K. Lohmann, J. Volkmann, C. Klein
Published in: Neurology, Issue 00283878, 2015, Page(s) 895-903, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000001312

Unraveling genomic variation from next generation sequencing data

Author(s): Georgios A Pavlopoulos, Anastasis Oulas, Ernesto Iacucci, Alejandro Sifrim, Yves Moreau, Reinhard Schneider, Jan Aerts, Ioannis Iliopoulos
Published in: BioData Mining, Issue 17560381, 2013, Page(s) 13, ISSN 1756-0381
Publisher: BioMed Central
DOI: 10.1186/1756-0381-6-13

Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease

Author(s): D. Weiss, R. Klotz, R. B. Govindan, M. Scholten, G. Naros, A. Ramos-Murguialday, F. Bunjes, C. Meisner, C. Plewnia, R. Kruger, A. Gharabaghi
Published in: Brain, Issue 00068950, 2015, Page(s) 679-693, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awu380

Neuromuscular correlates of subthalamic stimulation and upper limb freezing in Parkinson’s disease

Author(s): Marlieke Scholten, Rosa Klotz, Christian Plewnia, Tobias Wächter, Carina Mielke, Bastiaan R. Bloem, Christoph Braun, Ulf Ziemann, Rathinaswamy B. Govindan, Alireza Gharabaghi, Rejko Krüger, Daniel Weiss
Published in: Clinical Neurophysiology, Issue 13882457, 2016, Page(s) 610-620, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2015.02.012

EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts: Table1

Author(s): Johanna Huttenlocher, Rejko Krüger, Philipp Capetian, Katja Lohmann, Kathrin Brockmann, Ilona Csoti, Christine Klein, Daniela Berg, Thomas Gasser, Michael Bonin, Olaf Riess, Peter Bauer
Published in: Journal of Medical Genetics, Issue 00222593, 2014, Page(s) 37-41, ISSN 0022-2593
Publisher: British Medical Association
DOI: 10.1136/jmedgenet-2014-102570

TREM2 R47H variant and risk of essential tremor: A cross-sectional international multicenter study

Author(s): Sara Ortega-Cubero, Oswaldo Lorenzo-Betancor, Elena Lorenzo, José A.G. Agúndez, Félix J. Jiménez-Jiménez, Owen A. Ross, Isabel Wurster, Carina Mielke, Juei-Jueng Lin, Francisco Coria, Jordi Clarimon, Mario Ezquerra, Laura Brighina, Grazia Annesi, Hortensia Alonso-Navarro, Elena García-Martin, Alex Gironell, Maria J. Marti, Kuo-Chu Yueh, Zbigniew K. Wszolek, Manu Sharma, Daniela Berg, Rejko Krüger, Maria A. Pastor, Pau Pastor
Published in: Parkinsonism & Related Disorders, Issue 13538020, 2015, Page(s) 306-309, ISSN 1353-8020
Publisher: Elsevier BV
DOI: 10.1016/j.parkreldis.2014.12.010

Long-term outcome of deep brain stimulation in fragile X-associated tremor/ataxia syndrome

Author(s): Daniel Weiss, Carina Mielke, Tobias Wächter, Benjamin Bender, Rajka M. Liscic, Marlieke Scholten, Georgios Naros, Christian Plewnia, Alireza Gharabaghi, Rejko Krüger
Published in: Parkinsonism & Related Disorders, Issue 13538020, 2015, Page(s) 310-313, ISSN 1353-8020
Publisher: Elsevier BV
DOI: 10.1016/j.parkreldis.2014.12.015

Visualization of the medial forebrain bundle using diffusion tensor imaging

Author(s): Ardian Hana, Anisa Hana, Georges Dooms, Hans Boecher-Schwarz, Frank Hertel
Published in: Frontiers in Neuroanatomy, Issue 16625129, 2015, ISSN 1662-5129
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnana.2015.00139

The COMT Val/Met Polymorphism Modulates Effects of tDCS on Response Inhibition

Author(s): Vanessa Nieratschker, Christoph Kiefer, Katrin Giel, Rejko Krüger, Christian Plewnia
Published in: Brain Stimulation, Issue 1935861X, 2015, Page(s) 283-288, ISSN 1935-861X
Publisher: Elsevier BV
DOI: 10.1016/j.brs.2014.11.009

Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease - Report of the JPND Working Group BioLoC-PD

Author(s): Stefanie Lerche, Inga Liepelt-Scarfone, Guido Alves, Paolo Barone, Stefanie Behnke, Yoav Ben-Shlomo, Henk Berendse, David Burn, Richard Dodel, Donald Grosset, Sebastian Heinzel, Michele Hu, Meike Kasten, Rejko Kr�ger, Walter Maetzler, Marcello Moccia, Brit Mollenhauer, Wolfgang Oertel, Benjamin Roeben, Ulrike S�nkel, Uwe Walter, Karin Wirdefeldt, Daniela Berg
Published in: Neuroepidemiology, Issue 02515350, 2015, Page(s) 282-297, ISSN 0251-5350
Publisher: S. Karger AG
DOI: 10.1159/000439221

Deliverables

Publications

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