Enabling precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices

Project Information

CHEM2NATURE

Grant agreement ID: 692333

DOI 10.3030/692333

Project closed

EC signature date 2 December 2015

Start date 1 January 2016

End date 31 December 2018

Funded under

• Twinning of research institutions

Total cost € 1 007 453,75

EU contribution € 1 007 453,75

Coordinated by

UNIVERSIDADE DO MINHO
Portugal

Deliverables

Websites, patent fillings, videos etc. (12)

D5.5 Scientific publications in international peer-reviewed scientific journals (Month 36)
D5.1 Publications record of the coordinator organisation on the Participant Portal (Month 2)
D5.3 Open days sessions to the general public (Month 12)
D5.4 Press releases, project brochures, newsletters and web magazines (Month 12)
D5.5 Scientific publications in international peer-reviewed scientific journals (Month 24)
D5.4 Press releases, project brochures, newsletters and web magazines (Month 36)
D5.4 Press releases, project brochures, newsletters and web magazines (Month 24)
D5.6 Patent filling (Month 30)

D5.6 Patent filing (Month 30)

D5.2 Project website and collaborative network establishment (Month 4)
D5.7 Book on “advanced chemical modifications on natural systems” (Month 36)
D5.5 Scientific publications in international peer-reviewed scientific journals (Month 12)
D5.3 Open days sessions to the general public (Month 24)

Other (3)

D3.1 Request for a special issue in an ISI-indexed international journal – “Precision chemical modification of surfaces” (Month 24)
D4.1 Request for a special issue in an ISI-indexed international journal – “Engineering and chemical principles in cells encapsulation” (Month 36)
D2.1 Request for a special issue in an ISI-indexed international journal – “Chemical strategies for the modification of natural origin materials” (Month 11)

Publications

Peer reviewed articles (13)

Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence

Author(s): Rui R. Costa, Miguel González-Pérez, Marcos Herrero-Gutiérrez, Ricardo A. Pires, Matilde Alonso, J. Carlos Rodriguez-Cabello, Rui L. Reis, Iva Pashkuleva
Published in: Biomacromolecules, Issue 19/8, 2018, Page(s) 3401-3411, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00723

Redox-Responsive Micellar Nanoparticles from Glycosaminoglycans for CD44 Targeted Drug Delivery

Author(s): Ana M. Carvalho, Raquel Teixeira, Ramón Novoa-Carballal, Ricardo A. Pires, Rui L. Reis, Iva Pashkuleva
Published in: Biomacromolecules, Issue 19/7, 2018, Page(s) 2991-2999, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00561

Sponge-derived silica for tissue regeneration

Author(s): Olesia Dudik, Isabel Leonor, Joana R. Xavier, Hans Tore Rapp, Ricardo A. Pires, Tiago H. Silva, Rui L. Reis
Published in: Materials Today, Issue 21/5, 2018, Page(s) 577-578, ISSN 1369-7021
Publisher: Elsevier BV
DOI: 10.1016/j.mattod.2018.03.025

Star-Like Glycosaminoglycans with Superior Bioactivity Assemble with Proteins into Microfibers

Author(s): Ramon Novoa-Carballal, Agatha Carretero, Raul Pacheco, Rui L. Reis, Iva Pashkuleva
Published in: Chemistry - A European Journal, Issue 24/54, 2018, Page(s) 14341-14345, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201802243

Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells

Author(s): Sara Amorim, Diana Soares da Costa, Daniela Freitas, Celso A. Reis, Rui L. Reis, Iva Pashkuleva, Ricardo A. Pires
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-34445-0

Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles

Author(s): Alexandra Brito, Yousef M. Abul-Haija, Diana Soares da Costa, Ramon Novoa-Carballal, Rui L. Reis, Rein V. Ulijn, Ricardo A. Pires, Iva Pashkuleva
Published in: Chemical Science, Issue 10/8, 2019, Page(s) 2385-2390, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc04361b

Design of protein delivery systems by mimicking extracellular mechanisms for protection of growth factors

Author(s): Carla Silva, Agatha Carretero, Diana Soares da Costa, Rui L. Reis, Ramon Novoa-Carballal, Iva Pashkuleva
Published in: Acta Biomaterialia, Issue 63, 2017, Page(s) 283-293, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2017.08.042

Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue

Author(s): João S. Fernandes, Piergiorgio Gentile, Ricardo A. Pires, Rui L. Reis, Paul V. Hatton
Published in: Acta Biomaterialia, Issue 59, 2017, Page(s) 2-11, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2017.06.046

Sulfated Alginate as a Mimic of Sulfated Glycosaminoglycans: Binding of Growth Factors and Effect on Stem Cell Behavior

Author(s): Rami Mhanna, Jana Becher, Matthias Schnabelrauch, Rui L. Reis, Iva Pashkuleva
Published in: Advanced Biosystems, Issue 1/7, 2017, Page(s) 1700043, ISSN 2366-7478
Publisher: Wiley
DOI: 10.1002/adbi.201700043

Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behavior

Author(s): Bárbara B. Mendes, Manuel Gómez-Florit, Ricardo A. Pires, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Published in: Nanoscale, Issue 10/36, 2018, Page(s) 17388-17401, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nr04273j

Cork: Current Technological Developments and Future Perspectives for this Natural, Renewable, and Sustainable Material

Author(s): Ivo M. Aroso, Ana R. Araújo, Ricardo A. Pires, Rui L. Reis
Published in: ACS Sustainable Chemistry & Engineering, Issue 5/12, 2017, Page(s) 11130-11146, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.7b00751

Extracellular matrix-inspired assembly of glycosaminoglycan–collagen fibers

Author(s): A. Carretero, D. Soares da Costa, R. L. Reis, I. Pashkuleva
Published in: J. Mater. Chem. B, Issue 5/17, 2017, Page(s) 3103-3106, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7TB00704C

Nanoengineering Hybrid Supramolecular Multilayered Biomaterials Using Polysaccharides and Self-Assembling Peptide Amphiphiles

Author(s): João Borges, Maria P. Sousa, Goksu Cinar, Sofia G. Caridade, Mustafa O. Guler, João F. Mano
Published in: Advanced Functional Materials, Issue 27/17, 2017, Page(s) 1605122, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201605122