Publications Peer reviewed articles (37) Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease Author(s): Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, N Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-23909-z Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation Author(s): Jose M. Adrover, Alejandra Aroca-Crevillén, Georgiana Crainiciuc, Fernando Ostos, Yeny Rojas-Vega, Andrea Rubio-Ponce, Catia Cilloniz, Elena Bonzón-Kulichenko, Enrique Calvo, Daniel Rico, María A. Moro, Christian Weber, Ignacio Lizasoaín, Antoni Torres, Jesús Ruiz-Cabello, Jesús Vázquez, Andrés Hidalgo Published in: Nature Immunology, Issue 21/2, 2020, Page(s) 135-144, ISSN 1529-2908 Publisher: Nature Publishing Group DOI: 10.1038/s41590-019-0571-2 Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release Author(s): Virginia Egea, Kai Kessenbrock, Devon Lawson, Alexander Bartelt, Christian Weber, Christian Ries Published in: Cell Death & Disease, Issue 12/6, 2021, ISSN 2041-4889 Publisher: Nature Publishing Group DOI: 10.1038/s41419-021-03789-3 Expression and Cellular Localization of CXCR4 and CXCL12 in Human Carotid Atherosclerotic Plaques Author(s): Sophie Merckelbach, Emiel van der Vorst, Michael Kallmayer, Christoph Rischpler, Rainer Burgkart, Yvonne Döring, Gert-Jan de Borst, Markus Schwaiger, Hans-Henning Eckstein, Christian Weber, Jaroslav Pelisek Published in: Thrombosis and Haemostasis, Issue 118/01, 2018, Page(s) 195-206, ISSN 0340-6245 Publisher: Schattauer DOI: 10.1160/th17-04-0271 Immunoinflammatory, Thrombohaemostatic, and Cardiovascular Mechanisms in COVID-19 Author(s): Selin Gencer, Michael Lacy, Dorothee Atzler, Emiel P. C. van der Vorst, Yvonne Döring, Christian Weber Published in: Thrombosis and Haemostasis, Issue 120/12, 2020, Page(s) 1629-1641, ISSN 0340-6245 Publisher: Schattauer DOI: 10.1055/s-0040-1718735 Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting Author(s): Christos Kontos, Omar El Bounkari, Christine Krammer, Dzmitry Sinitski, Kathleen Hille, Chunfang Zan, Guangyao Yan, Sijia Wang, Ying Gao, Markus Brandhofer, Remco T. A. Megens, Adrian Hoffmann, Jessica Pauli, Yaw Asare, Simona Gerra, Priscila Bourilhon, Lin Leng, Hans-Henning Eckstein, Wolfgang E. Kempf, Jaroslav Pelisek, Ozgun Gokce, Lars Maegdefessel, Richard Bucala, Martin Dichgans, Christian W Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-19764-z Systematic RNA-interference in primary human monocyte-derived macrophages: A high-throughput platform to study foam cell formation Author(s): Gabriele Domschke, Fabian Linden, Lukas Pawig, Anna Hafner, Mohammadreza Akhavanpoor, Jürgen Reymann, Andreas O. Doesch, Christian Erbel, Christian Weber, Hugo A. Katus, Heidi Noels, Holger Erfle, Christian A. Gleissner, Heiko Runz Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-018-28790-3 B-Cell–Specific CXCR4 Protects Against Atherosclerosis Development and Increases Plasma IgM Levels Author(s): Yvonne Döring, Yvonne Jansen, Ismail Cimen, Maria Aslani, Selin Gencer, Linsey J.F. Peters, Johan Duchene, Christian Weber, Emiel P.C. van der Vorst Published in: Circulation Research, Issue 126/6, 2020, Page(s) 787-788, ISSN 0009-7330 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/circresaha.119.316142 Double bond configuration of palmitoleate is critical for atheroprotection Author(s): Ismail Cimen, Zehra Yildirim, Asli Ekin Dogan, Asli Dilber Yildirim, Ozlem Tufanli, Umut Inci Onat, UyenThao Nguyen, Steven M. Watkins, Christian Weber, Ebru Erbay Published in: Molecular Metabolism, Issue 28, 2019, Page(s) 58-72, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2019.08.004 Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue Author(s): Selin Gencer, Yvonne Döring, Yvonne Jansen, Soyolmaa Bayasgalan, Olga Schengel, Madeleine Müller, Linsey J. F. Peters, Christian Weber, Emiel P. C. van der Vorst Published in: Biomedicines, Issue 9/4, 2021, Page(s) 394, ISSN 2227-9059 Publisher: MDPI DOI: 10.3390/biomedicines9040394 Seeing is repairing: how imaging-based timely interference with CXCR4 could improve repair after myocardial infarction Author(s): Yvonne Döring, Heidi Noels, Emiel van der Vorst, Christian Weber Published in: European Heart Journal, Issue 41/37, 2020, Page(s) 3576-3578, ISSN 0195-668X Publisher: Oxford University Press DOI: 10.1093/eurheartj/ehaa625 Chemokines and galectins form heterodimers to modulate inflammation Author(s): Veit Eckardt, Michelle C Miller, Xavier Blanchet, Rundan Duan, Julian Leberzammer, Johan Duchene, Oliver Soehnlein, Remco TA Megens, Anna‐Kristin Ludwig, Aurelio Dregni, Alexander Faussner, Kanin Wichapong, Hans Ippel, Ingrid Dijkgraaf, Herbert Kaltner, Yvonne Döring, Kiril Bidzhekov, Tilman M Hackeng, Christian Weber, Hans‐Joachim Gabius, Philipp Hundelshausen, Kevin H Mayo Published in: EMBO reports, Issue 21/4, 2020, ISSN 1469-221X Publisher: Nature Publishing Group DOI: 10.15252/embr.201947852 Autophagy unleashes noncanonical microRNA functions Author(s): Donato Santovito, Virginia Egea, Kiril Bidzhekov, Lucia Natarelli, André Mourão, Xavier Blanchet, Kanin Wichapong, Maria Aslani, Coy Brunßen, Michael Horckmans, Michael Hristov, Arie Geerlof, Esther Lutgens, Mat J. A. P. Daemen, Tilman Hackeng, Christian Ries, Triantafyllos Chavakis, Henning Morawietz, Ronald Naumann, Philipp Von Hundelshausen, Sabine Steffens, Johan Duchêne, Remco T. A. Megen Published in: Autophagy, Issue 16/12, 2020, Page(s) 2294-2296, ISSN 1554-8627 Publisher: Landes Bioscience DOI: 10.1080/15548627.2020.1830523 PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function Author(s): Mariaelvy Bianchini, Johan Duchêne, Donato Santovito, Maximilian J. Schloss, Maximilien Evrard, Holger Winkels, Maria Aslani, Sarajo K. Mohanta, Michael Horckmans, Xavier Blanchet, Michael Lacy, Philipp von Hundelshausen, Dorothee Atzler, Andreas Habenicht, Norbert Gerdes, Jaroslav Pelisek, Lai Guan Ng, Sabine Steffens, Christian Weber, Remco T. A. Megens Published in: Science Immunology, Issue 4/36, 2019, Page(s) eaar3054, ISSN 2470-9468 Publisher: American Association for the Advancement of Science DOI: 10.1126/sciimmunol.aar3054 Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis Author(s): Donato Santovito, Virginia Egea, Kiril Bidzhekov, Lucia Natarelli, André Mourão, Xavier Blanchet, Kanin Wichapong, Maria Aslani, Coy Brunßen, Michael Horckmans, Michael Hristov, Arie Geerlof, Esther Lutgens, Mat J.A.P. Daemen, Tilman Hackeng, Christian Ries, Triantafyllos Chavakis, Henning Morawietz, Ronald Naumann, Philipp von Hundelshausen, Sabine Steffens, Johan Duchêne, Remco T.A. Megens, Published in: Science Translational Medicine, Issue 12/546, 2020, Page(s) eaaz2294, ISSN 1946-6234 Publisher: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.aaz2294 G-Protein Coupled Receptor Targeting on Myeloid Cells in Atherosclerosis Author(s): Emiel P. C. van der Vorst, Linsey J. F. Peters, Madeleine Müller, Selin Gencer, Yi Yan, Christian Weber, Yvonne Döring Published in: Frontiers in Pharmacology, Issue 10, 2019, ISSN 1663-9812 Publisher: Frontiers Media S.A. DOI: 10.3389/fphar.2019.00531 Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis Author(s): Johan Duchene, Igor Novitzky-Basso, Aude Thiriot, Maria Casanova-Acebes, Mariaelvy Bianchini, S Leah Etheridge, Elin Hub, Katrin Nitz, Katharina Artinger, Kathrin Eller, Jorge Caamaño, Thomas Rülicke, Paul Moss, Remco T A Megens, Ulrich H von Andrian, Andres Hidalgo, Christian Weber, Antal Rot Published in: Nature Immunology, Issue 18/7, 2017, Page(s) 753-761, ISSN 1529-2908 Publisher: Nature Publishing Group DOI: 10.1038/ni.3763 Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation Author(s): Philipp von Hundelshausen, Stijn M. Agten, Veit Eckardt, Xavier Blanchet, Martin M. Schmitt, Hans Ippel, Carlos Neideck, Kiril Bidzhekov, Julian Leberzammer, Kanin Wichapong, Alexander Faussner, Maik Drechsler, Jochen Grommes, Johanna P. van Geffen, He Li, Almudena Ortega-Gomez, Remco T. A. Megens, Ronald Naumann, Ingrid Dijkgraaf, Gerry A. F. Nicolaes, Yvonne Döring, Oliver Soehnlein, Esther Lut Published in: Science Translational Medicine, Issue 9/384, 2017, Page(s) eaah6650, ISSN 1946-6234 Publisher: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.aah6650 Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer 68 Ga-Pentixafor for PET Author(s): Fabien Hyafil, Jaroslav Pelisek, Iina Laitinen, Margret Schottelius, Miriam Mohring, Yvonne Döring, Emiel P.C. van der Vorst, Michael Kallmayer, Katja Steiger, Andreas Poschenrieder, Johannes Notni, Johannes Fischer, Christine Baumgartner, Christoph Rischpler, Stephan G. Nekolla, Christian Weber, Hans-Henning Eckstein, Hans-Jürgen Wester, Markus Schwaiger Published in: Journal of Nuclear Medicine, Issue 58/3, 2017, Page(s) 499-506, ISSN 0161-5505 Publisher: Kexue Chubaneshe/Science Press DOI: 10.2967/jnumed.116.179663 Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4 Author(s): Michael Lacy, Christos Kontos, Markus Brandhofer, Kathleen Hille, Sabine Gröning, Dzmitry Sinitski, Priscila Bourilhon, Eric Rosenberg, Christine Krammer, Tharshika Thavayogarajah, Georgios Pantouris, Maria Bakou, Christian Weber, Elias Lolis, Jürgen Bernhagen, Aphrodite Kapurniotu Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-018-23554-5 Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial IntegrityClinical Perspective Author(s): Yvonne Döring, Heidi Noels, Emiel P.C. van der Vorst, Carlos Neideck, Virginia Egea, Maik Drechsler, Manuela Mandl, Lukas Pawig, Yvonne Jansen, Katrin Schröder, Kiril Bidzhekov, Remco T.A. Megens, Wendy Theelen, Barbara M. Klinkhammer, Peter Boor, Leon Schurgers, Rick van Gorp, Christian Ries, Pascal J.H. Kusters, Allard van der Wal, Tilman M. Hackeng, Gabor Gäbel, Ralf P. Brandes, Oliver Soehn Published in: Circulation, Issue 136/4, 2017, Page(s) 388-403, ISSN 0009-7322 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/CIRCULATIONAHA.117.027646 Novel Features of Monocytes and Macrophages in Cardiovascular Biology and Disease Author(s): Emiel P.C. van der Vorst, Christian Weber Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 39/2, 2019, ISSN 1079-5642 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/atvbaha.118.312002 Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives Author(s): Wolfgang Poller, Stefanie Dimmeler, Stephane Heymans, Tanja Zeller, Jan Haas, Mahir Karakas, David-Manuel Leistner, Philipp Jakob, Shinichi Nakagawa, Stefan Blankenberg, Stefan Engelhardt, Thomas Thum, Christian Weber, Benjamin Meder, Roger Hajjar, Ulf Landmesser Published in: European Heart Journal, Issue 39/29, 2017, Page(s) 2704-2716, ISSN 0195-668X Publisher: Oxford University Press DOI: 10.1093/eurheartj/ehx165 CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease Author(s): Yvonne Döring, Emiel P.C. van der Vorst, Johan Duchene, Yvonne Jansen, Selin Gencer, Kiril Bidzhekov, Dorothee Atzler, Donato Santovito, Daniel J. Rader, Danish Saleheen, Christian Weber Published in: Circulation, Issue 139/10, 2019, Page(s) 1338-1340, ISSN 0009-7322 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/circulationaha.118.037953 Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis Author(s): Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax Published in: Journal of the American College of Cardiology, Issue 71/5, 2018, Page(s) 527-542, ISSN 0735-1097 Publisher: Elsevier BV DOI: 10.1016/j.jacc.2017.11.055 ApoE attenuates unresolvable inflammation by complex formation with activated C1q Author(s): Changjun Yin, Susanne Ackermann, Zhe Ma, Sarajo K. Mohanta, Chuankai Zhang, Yuanfang Li, Sandor Nietzsche, Martin Westermann, Li Peng, Desheng Hu, Sai Vineela Bontha, Prasad Srikakulapu, Michael Beer, Remco T. A. Megens, Sabine Steffens, Markus Hildner, Luke D. Halder, Hans-Henning Eckstein, Jaroslav Pelisek, Jochen Herms, Sigrun Roeber, Thomas Arzberger, Anna Borodovsky, Livia Habenicht, Christop Published in: Nature Medicine, Issue 25/3, 2019, Page(s) 496-506, ISSN 1078-8956 Publisher: Nature Publishing Group DOI: 10.1038/s41591-018-0336-8 Microvesicles in vascular homeostasis and diseases Author(s): Anne Angelillo-Scherrer, Lina Badimon, Olivier Blanc-Brude, Marie-Luce Bochaton-Piallat, Eric Boilard, Edit I. Buzas, Andreas Caporali, Francoise Dignat-George, Paul C. Evans, Romaric Lacroix, Esther Lutgens, Daniel F. J. Ketelhuth, Rienk Nieuwland, Florence Toti, Jose Tuñon, Christian Weber, Imo E. Hoefer, Gregory Y. H. Lip, Nikos Werner, Eduard Shantsila, Hugo ten Cate, Mark Thomas, Paul Harris Published in: Thrombosis and Haemostasis, Issue 117/07, 2017, Page(s) 1296-1316, ISSN 0340-6245 Publisher: Schattauer DOI: 10.1160/th16-12-0943 Neutrophils as protagonists and targets in chronic inflammation Author(s): Oliver Soehnlein, Sabine Steffens, Andrés Hidalgo, Christian Weber Published in: Nature Reviews Immunology, Issue 17/4, 2017, Page(s) 248-261, ISSN 1474-1733 Publisher: Nature Publishing Group DOI: 10.1038/nri.2017.10 Mif -deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis Author(s): Corinna Schmitz, Heidi Noels, Omar El Bounkari, Eva Straussfeld, Remco T. A. Megens, Marieke Sternkopf, Setareh Alampour-Rajabi, Christine Krammer, Pathricia V. Tilstam, Norbert Gerdes, Christina Bürger, Aphrodite Kapurniotu, Richard Bucala, Joachim Jankowski, Christian Weber, Jürgen Bernhagen Published in: The FASEB Journal, Issue 32/8, 2018, Page(s) 4428-4443, ISSN 0892-6638 Publisher: Federation of American Societies for Experimental Biology DOI: 10.1096/fj.201800058r Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis Author(s): Carla Winter, Carlos Silvestre-Roig, Almudena Ortega-Gomez, Patricia Lemnitzer, Hessel Poelman, Ariane Schumski, Janine Winter, Maik Drechsler, Renske de Jong, Roland Immler, Markus Sperandio, Michael Hristov, Tanja Zeller, Gerry A.F. Nicolaes, Christian Weber, Joana R. Viola, Andres Hidalgo, Christoph Scheiermann, Oliver Soehnlein Published in: Cell Metabolism, Issue 28/1, 2018, Page(s) 175-182.e5, ISSN 1550-4131 Publisher: Cell Press DOI: 10.1016/j.cmet.2018.05.002 Immunotherapy for cardiovascular disease Author(s): Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber Published in: European Heart Journal, 2019, ISSN 0195-668X Publisher: Oxford University Press DOI: 10.1093/eurheartj/ehz283 Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death Author(s): Carlos Silvestre-Roig, Quinte Braster, Kanin Wichapong, Ernest Y. Lee, Jean Marie Teulon, Nihel Berrebeh, Janine Winter, José M. Adrover, Giancarlo Santiago Santos, Alexander Froese, Patricia Lemnitzer, Almudena Ortega-Gómez, Raphael Chevre, Julian Marschner, Ariane Schumski, Carla Winter, Laura Perez-Olivares, Chang Pan, Nicole Paulin, Tom Schoufour, Helene Hartwig, Silvia González-Ramos, Frit Published in: Nature, Issue 569/7755, 2019, Page(s) 236-240, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-019-1167-6 A Neutrophil Timer Coordinates Immune Defense and Vascular Protection Author(s): José M. Adrover, Carlos del Fresno, Georgiana Crainiciuc, Maria Isabel Cuartero, María Casanova-Acebes, Linnea A. Weiss, Hector Huerga-Encabo, Carlos Silvestre-Roig, Jan Rossaint, Itziar Cossío, Ana V. Lechuga-Vieco, Jaime García-Prieto, Mónica Gómez-Parrizas, Juan A. Quintana, Ivan Ballesteros, Sandra Martin-Salamanca, Alejandra Aroca-Crevillen, Shu Zhen Chong, Maximilien Evrard, Karl Balab Published in: Immunity, Issue 50/2, 2019, Page(s) 390-402.e10, ISSN 1074-7613 Publisher: Cell Press DOI: 10.1016/j.immuni.2019.01.002 Neutrophils instruct homeostatic and pathological states in naive tissues Author(s): Maria Casanova-Acebes, José A. Nicolás-Ávila, Jackson LiangYao Li, Susana García-Silva, Akhila Balachander, Andrea Rubio-Ponce, Linnea A. Weiss, José M. Adrover, Kyle Burrows, Noelia A-González, Ivan Ballesteros, Sapna Devi, Juan A. Quintana, Georgiana Crainiciuc, Magdalena Leiva, Matthias Gunzer, Christian Weber, Takashi Nagasawa, Oliver Soehnlein, Miriam Merad, Arthur Mortha, Lai Guan Ng, Published in: Journal of Experimental Medicine, Issue 215/11, 2018, Page(s) 2778-2795, ISSN 0022-1007 Publisher: Rockefeller University Press DOI: 10.1084/jem.20181468 Metabolomic profiling of atherosclerotic plaques: towards improved cardiovascular risk stratification Author(s): Emiel P C van der Vorst, Christian Weber Published in: European Heart Journal, Issue 39/24, 2018, Page(s) 2311-2313, ISSN 0195-668X Publisher: Oxford University Press DOI: 10.1093/eurheartj/ehy117 The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice Author(s): Klytaimnistra Kiouptsi, Sven Jäckel, Giulia Pontarollo, Alexandra Grill, Marijke J. E. Kuijpers, Eivor Wilms, Christian Weber, Felix Sommer, Magdolna Nagy, Carlos Neideck, Yvonne Jansen, Stefanie Ascher, Henning Formes, Cornelia Karwot, Franziska Bayer, Bettina Kollar, Saravanan Subramaniam, Michael Molitor, Philip Wenzel, Philip Rosenstiel, Hristo Todorov, Susanne Gerber, Ulrich Walter, Kerstin Published in: mBio, Issue 10/5, 2019, ISSN 2161-2129 Publisher: American Society for Microbiology DOI: 10.1128/mbio.02298-19 Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia Author(s): Elke Butt, Katrin Stempfle, Lorenz Lister, Felix Wolf, Marcella Kraft, Andreas B. Herrmann, Cristina Perpina Viciano, Christian Weber, Andreas Hochhaus, Thomas Ernst, Carsten Hoffmann, Alma Zernecke, Jochen J. Frietsch Published in: Cells, Issue 9/2, 2020, Page(s) 444, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells9020444 Searching for OpenAIRE data... 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