Periodic Reporting for period 4 - MEDICI (The inflammatory gene expression program in macrophages: An integrative approach for the systematic characterization of transcriptional co-regulators)
Période du rapport: 2021-07-01 au 2022-10-31
The activation of the inflammatory response requires the deployment of a complex gene expression program that has to be carefully adapted to the type of damage and to its intensity. Thanks to the rational combination of a panel of genomic technologies, many of the regulatory mechanisms that control changes in gene expression triggered by inflammatory stimuli have been clarified in the last years. However, the macromolecular machineries working in the nucleus of mammalian cells and involved in the control of inflammatory gene expression, are largely unknown. This project aimed at contributing to fill such knowledge gap by integrating genetics with high throughput genomic sequencing approaches and advanced computational and mathematical data analyses.