NMDA receptor diversity: from molecular dynamics to synaptic physiopathology

Project Information

NMDADYN

Grant agreement ID: 693021

DOI 10.3030/693021

Project closed

EC signature date 7 June 2016

Start date 1 November 2016

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Publications

Peer reviewed articles (21)

Mechanisms of NMDA receptor regulation

Author(s): Laetitia Mony, Pierre Paoletti
Published in: Current Opinion in Neurobiology, 2023, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2023.102815

GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits

Author(s): Simon Bossi; Dhanasak Dhanasobhon; Graham C.R. Ellis-Davies; Jimena Frontera; Marcel de Brito Van Velze; Joana Lourenço; Alvaro Murillo; Rafael Luján; Mariano Casado; Isabel Perez-Otaño; Alberto Bacci; Daniela Popa; Pierre Paoletti; Nelson Rebola
Published in: Neuron, Issue 5, 2022, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.05.016

Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.

Author(s): María J Conde-Dusman; Partha N Dey; Óscar Elía-Zudaire; Luis G. Rabaneda; Carmen García-Lira; Teddy Grand; Víctor Briz; Eric R. Velasco; Raül Andero; Sergio Niñerola; Angel Barco; Pierre Paoletti; John F. Wesseling; Fabrizio Gardoni; Steven J. Tavalin; Isabel Pérez-Otaño
Published in: eLife, Issue 3, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.71575

Activity-dependent modulation of NMDA receptors by endogenous zinc shapes dendritic function in cortical neurons

Author(s): Annunziato Morabito; Yann Zerlaut; Benjamin Serraz; Romain Sala; Pierre Paoletti; Nelson Rebola
Published in: Cell Reports, Issue 4, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110415

Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors

Author(s): Han Wang, Shiyun Lv, David Stroebel, Jinbao Zhang, Yijie Pan, Xuejing Huang, Xing Zhang, Pierre Paoletti, Shujia Zhu
Published in: Neuron, 2021, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2021.05.031

Architecture and function of NMDA receptors: an evolutionary perspective

Author(s): David Stroebel, Pierre Paoletti
Published in: The Journal of Physiology, Issue 599/10, 2021, Page(s) 2615-2638, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp279028

Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice

Author(s): Wangyong Shin, Kyungdeok Kim, Benjamin Serraz, Yi Sul Cho, Doyoun Kim, Muwon Kang, Eun-Jae Lee, Hyejin Lee, Yong Chul Bae, Pierre Paoletti, Eunjoon Kim
Published in: PLOS Biology, Issue 18/4, 2020, Page(s) e3000717, ISSN 1545-7885
Publisher: Public Library of Sciences
DOI: 10.1371/journal.pbio.3000717

GluN2A and GluN2B NMDA receptors use distinct allosteric routes

Author(s): Meilin Tian, David Stroebel, Laura Piot, Mélissa David, Shixin Ye, Pierre Paoletti
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25058-9

Photochemical Control of Drug Efficacy: A Comparison of Uncaging and Photoswitching Ifenprodil on NMDA Receptors

Author(s): Ek Raj Thapaliya; Laetitia Mony; Roberto Sanchez; Benjamin Serraz; Pierre Paoletti; Graham C. R. Ellis-Davies
Published in: ChemPhotoChem, Issue 5, 2021, ISSN 2367-0932
Publisher: Wiley
DOI: 10.1002/cptc.202000240

Optocontrol of glutamate receptor activity by single side-chain photoisomerization

Author(s): Viktoria Klippenstein, Christian Hoppmann, Shixin Ye, Lei Wang, Pierre Paoletti
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.25808

Probing Ion Channel Structure and Function Using Light-Sensitive Amino Acids

Author(s): Viktoria Klippenstein, Laetitia Mony, Pierre Paoletti
Published in: Trends in Biochemical Sciences, Issue 43/6, 2018, Page(s) 436-451, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2018.02.012

Triheteromeric NMDA receptors: from structure to synaptic physiology

Author(s): David Stroebel, Mariano Casado, Pierre Paoletti
Published in: Current Opinion in Physiology, Issue 2, 2018, Page(s) 1-12, ISSN 2468-8673
Publisher: Elsevier BV
DOI: 10.1016/j.cophys.2017.12.004

Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses

Author(s): Joana S Ferreira, Thomas Papouin, Laurent Ladépêche, Andrea Yao, Valentin C Langlais, Delphine Bouchet, Jérôme Dulong, Jean-Pierre Mothet, Silvia Sacchi, Loredano Pollegioni, Pierre Paoletti, Stéphane Henri Richard Oliet, Laurent Groc
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.25492

An inter‐dimer allosteric switch controls NMDA receptor activity

Author(s): Jean‐Baptiste Esmenjaud, David Stroebel, Kelvin Chan, Teddy Grand, Mélissa David, Lonnie P Wollmuth, Antoine Taly, Pierre Paoletti
Published in: The EMBO Journal, Issue 38/2, 2019, Page(s) e99894, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201899894

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors

Author(s): Teddy Grand, Sarah Abi Gerges, Mélissa David, Marco A. Diana, Pierre Paoletti
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07236-4

Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Author(s): Lulu Yao, Teddy Grand, Jesse E. Hanson, Pierre Paoletti, Qiang Zhou
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06512-7

Optical control of neuronal ion channels and receptors

Author(s): Pierre Paoletti, Graham C. R. Ellis-Davies, Alexandre Mourot
Published in: Nature Reviews Neuroscience, Issue 20/9, 2019, Page(s) 514-532, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-019-0197-2

Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula

Author(s): Y. Otsu, E. Darcq, K. Pietrajtis, F. Mátyás, E. Schwartz, T. Bessaih, S. Abi Gerges, C. V. Rousseau, T. Grand, S. Dieudonné, P. Paoletti, L. Acsády, C. Agulhon, B. L. Kieffer, M. A. Diana
Published in: Science, Issue 366/6462, 2019, Page(s) 250-254, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax1522

Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson's disease

Author(s): Joanna Sikora, Brigitte L. Kieffer, Pierre Paoletti, Abdel-Mouttalib Ouagazzal
Published in: Neurobiology of Disease, Issue 134, 2020, Page(s) 104681, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2019.104681

Zn2+ inhibits spatial memory and hippocampal place cell representation through high-affinity binding to the NMDA receptor GluN2A subunit

Author(s): Joanna Sikora, Sonia Di Bisceglie Caballero, David Reiss, Brigitte L Kieffer, Pierre Paoletti, Pierre-Yves Jacob, Abdel-Mouttalib Ouagazzal
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2022.105355

Glycine agonism in ionotropic glutamate receptors

Author(s): David Stroebel, Laetitia Mony, Pierre Paoletti
Published in: Neuropharmacology, Issue 193, 2021, Page(s) 108631, ISSN 0028-3908
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2021.108631

Non-peer reviewed articles (2)

Editorial: Latest Advances on Excitatory Synapse Biology

Author(s): Kimberly M. Huber; Pierre Paoletti; P. Jesper Sjöström
Published in: Frontiers in Synaptic Neuroscience, Issue 1, 2021, ISSN 1663-3563
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2021.768651

Photocontrol of Metabotropic Glutamate Receptors: When One Agonist Is Not Enough, Make It Two

Author(s): Laetitia Mony, Pierre Paoletti
Published in: Neuron, Issue 105/3, 2020, Page(s) 395-397, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.01.013