NMDA receptor diversity: from molecular dynamics to synaptic physiopathology

Project Information

NMDADYN

Grant agreement ID: 693021

DOI

10.3030/693021

Project closed

EC signature date 7 June 2016

Start date 1 November 2016

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

Mechanisms of NMDA receptor regulation

Author(s): Laetitia Mony, Pierre Paoletti
Published in: Current Opinion in Neurobiology, 2023, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2023.102815

GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits

Author(s): Simon Bossi; Dhanasak Dhanasobhon; Graham C.R. Ellis-Davies; Jimena Frontera; Marcel de Brito Van Velze; Joana Lourenço; Alvaro Murillo; Rafael Luján; Mariano Casado; Isabel Perez-Otaño; Alberto Bacci; Daniela Popa; Pierre Paoletti; Nelson Rebola
Published in: Neuron, Issue 5, 2022, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.05.016

Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.

Author(s): María J Conde-Dusman; Partha N Dey; Óscar Elía-Zudaire; Luis G. Rabaneda; Carmen García-Lira; Teddy Grand; Víctor Briz; Eric R. Velasco; Raül Andero; Sergio Niñerola; Angel Barco; Pierre Paoletti; John F. Wesseling; Fabrizio Gardoni; Steven J. Tavalin; Isabel Pérez-Otaño
Published in: eLife, Issue 3, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.71575

Activity-dependent modulation of NMDA receptors by endogenous zinc shapes dendritic function in cortical neurons

Author(s): Annunziato Morabito; Yann Zerlaut; Benjamin Serraz; Romain Sala; Pierre Paoletti; Nelson Rebola
Published in: Cell Reports, Issue 4, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110415

Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors

Author(s): Han Wang, Shiyun Lv, David Stroebel, Jinbao Zhang, Yijie Pan, Xuejing Huang, Xing Zhang, Pierre Paoletti, Shujia Zhu
Published in: Neuron, 2021, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2021.05.031

Architecture and function of NMDA receptors: an evolutionary perspective

Author(s): David Stroebel, Pierre Paoletti
Published in: The Journal of Physiology, Issue 599/10, 2021, Page(s) 2615-2638, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp279028

Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice

Author(s): Wangyong Shin, Kyungdeok Kim, Benjamin Serraz, Yi Sul Cho, Doyoun Kim, Muwon Kang, Eun-Jae Lee, Hyejin Lee, Yong Chul Bae, Pierre Paoletti, Eunjoon Kim
Published in: PLOS Biology, Issue 18/4, 2020, Page(s) e3000717, ISSN 1545-7885
Publisher: Public Library of Sciences
DOI: 10.1371/journal.pbio.3000717

GluN2A and GluN2B NMDA receptors use distinct allosteric routes

Author(s): Meilin Tian, David Stroebel, Laura Piot, Mélissa David, Shixin Ye, Pierre Paoletti
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25058-9

Photochemical Control of Drug Efficacy: A Comparison of Uncaging and Photoswitching Ifenprodil on NMDA Receptors

Author(s): Ek Raj Thapaliya; Laetitia Mony; Roberto Sanchez; Benjamin Serraz; Pierre Paoletti; Graham C. R. Ellis-Davies
Published in: ChemPhotoChem, Issue 5, 2021, ISSN 2367-0932
Publisher: Wiley
DOI: 10.1002/cptc.202000240

Optocontrol of glutamate receptor activity by single side-chain photoisomerization

Author(s): Viktoria Klippenstein, Christian Hoppmann, Shixin Ye, Lei Wang, Pierre Paoletti
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.25808

Probing Ion Channel Structure and Function Using Light-Sensitive Amino Acids

Author(s): Viktoria Klippenstein, Laetitia Mony, Pierre Paoletti
Published in: Trends in Biochemical Sciences, Issue 43/6, 2018, Page(s) 436-451, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2018.02.012

Triheteromeric NMDA receptors: from structure to synaptic physiology

Author(s): David Stroebel, Mariano Casado, Pierre Paoletti
Published in: Current Opinion in Physiology, Issue 2, 2018, Page(s) 1-12, ISSN 2468-8673
Publisher: Elsevier BV
DOI: 10.1016/j.cophys.2017.12.004

Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses

Author(s): Joana S Ferreira, Thomas Papouin, Laurent Ladépêche, Andrea Yao, Valentin C Langlais, Delphine Bouchet, Jérôme Dulong, Jean-Pierre Mothet, Silvia Sacchi, Loredano Pollegioni, Pierre Paoletti, Stéphane Henri Richard Oliet, Laurent Groc
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.25492

An inter‐dimer allosteric switch controls NMDA receptor activity

Author(s): Jean‐Baptiste Esmenjaud, David Stroebel, Kelvin Chan, Teddy Grand, Mélissa David, Lonnie P Wollmuth, Antoine Taly, Pierre Paoletti
Published in: The EMBO Journal, Issue 38/2, 2019, Page(s) e99894, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201899894

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors

Author(s): Teddy Grand, Sarah Abi Gerges, Mélissa David, Marco A. Diana, Pierre Paoletti
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07236-4

Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Author(s): Lulu Yao, Teddy Grand, Jesse E. Hanson, Pierre Paoletti, Qiang Zhou
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06512-7

Optical control of neuronal ion channels and receptors

Author(s): Pierre Paoletti, Graham C. R. Ellis-Davies, Alexandre Mourot
Published in: Nature Reviews Neuroscience, Issue 20/9, 2019, Page(s) 514-532, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-019-0197-2

Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula

Author(s): Y. Otsu, E. Darcq, K. Pietrajtis, F. Mátyás, E. Schwartz, T. Bessaih, S. Abi Gerges, C. V. Rousseau, T. Grand, S. Dieudonné, P. Paoletti, L. Acsády, C. Agulhon, B. L. Kieffer, M. A. Diana
Published in: Science, Issue 366/6462, 2019, Page(s) 250-254, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax1522

Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson's disease

Author(s): Joanna Sikora, Brigitte L. Kieffer, Pierre Paoletti, Abdel-Mouttalib Ouagazzal
Published in: Neurobiology of Disease, Issue 134, 2020, Page(s) 104681, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2019.104681

Zn2+ inhibits spatial memory and hippocampal place cell representation through high-affinity binding to the NMDA receptor GluN2A subunit

Author(s): Joanna Sikora, Sonia Di Bisceglie Caballero, David Reiss, Brigitte L Kieffer, Pierre Paoletti, Pierre-Yves Jacob, Abdel-Mouttalib Ouagazzal
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2022.105355

Glycine agonism in ionotropic glutamate receptors

Author(s): David Stroebel, Laetitia Mony, Pierre Paoletti
Published in: Neuropharmacology, Issue 193, 2021, Page(s) 108631, ISSN 0028-3908
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2021.108631

Non-peer reviewed articles (2)

Editorial: Latest Advances on Excitatory Synapse Biology

Author(s): Kimberly M. Huber; Pierre Paoletti; P. Jesper Sjöström
Published in: Frontiers in Synaptic Neuroscience, Issue 1, 2021, ISSN 1663-3563
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2021.768651

Photocontrol of Metabotropic Glutamate Receptors: When One Agonist Is Not Enough, Make It Two

Author(s): Laetitia Mony, Pierre Paoletti
Published in: Neuron, Issue 105/3, 2020, Page(s) 395-397, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.01.013