Memory and innate-like B-cell subsets: deciphering a multi-layered B-cell response in mice and humans

Project Information

B-response

Grant agreement ID: 693267

DOI

10.3030/693267

Project closed

EC signature date 12 August 2016

Start date 1 September 2016

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 098 750,00

EU contribution

€ 2 098 750,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Analysis of mRNA vaccination-elicited RBD-specific memory B cells reveals strong but incomplete immune escape of the SARS-CoV-2 Omicron variant.

Author(s): Sokal A, Broketa M, Barba-Spaeth G, Meola A, Fernández I, Fourati S, Azzaoui I, de La Selle A, Vandenberghe A, Roeser A, Bouvier-Alias M, Crickx E, Languille L, Michel M, Godeau B, Gallien S, Melica G, Nguyen Y, Zarrouk V, Canoui-Poitrine F, Noizat-Pirenne F, Megret J, Pawlotsky JM, Fillatreau S, Simon-Lorière E, Weill JC, Reynaud CA, Rey FA, Bruhns P, Chappert P, Mahévas M.
Published in: Immunity, Issue 55, June 14, 2022, Page(s) 1096-1104, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.04.002

Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting

Author(s): Chappert P, Huetz F, Espinasse MA, Chatonnet F, Pannetier L, Da Silva L, Goetz C, Mégret J, Sokal A, Crickx E, Nemazanyy I, Jung V, Guerrera C, Storck S, Mahévas M, Cosma A, Revy P, Fest T, Reynaud CA, Weill JC
Published in: Immunity, Issue 55, October 11, 2022, Page(s) 1872-1890, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.08.019

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

Author(s): Aurélien Sokal, Pascal Chappert, Giovanna Barba-Spaeth, Anais Roeser, Slim Fourati, Imane Azzaoui, Alexis Vandenberghe, Ignacio Fernandez, Annalisa Meola, Magali Bouvier-Alias, Etienne Crickx, Asma Beldi-Ferchiou, Sophie Hue, Laetitia Languille, Marc Michel, Samia Baloul, France Noizat-Pirenne, Marine Luka, Jérôme Mégret, Mickaël Ménager, Jean-Michel Pawlotsky, Simon Fillatreau, Felix A. Rey
Published in: Cell, Issue 184/5, 2021, Page(s) 1201-1213.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.01.050

T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens

Author(s): Weller S, Sterlin D, Fadeev T, Coignard E, Verge de Los Aires A, Goetz C, Fritzen R, Bahuaud M, Batteux F, Gorochov G, Weill JC, Reynaud CA.
Published in: Science Immunology, Issue Jan 27; 8(79), 2023, Page(s) eade1413, ISSN 2470-9468
Publisher: AAAS
DOI: 10.1126/sciimmunol.ade1413

B cell intrinsic and extrinsic factors impacting memory recall responses to SRBC challenge.

Author(s): Valeri V, Sochon A, Ye C, Mao X, Lecoeuche D, Fillatreau S, Weill JC, Reynaud CA, Hao Y
Published in: Frontiers in Immunology, Issue 16643224, 2022, Page(s) 873886, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2022.873886

The whole-cell pertussis vaccine imposes a broad effector B cell response in mouse heterologous prime-boost settings

Author(s): Valeri V , Sochon A , Cousu C , Chappert P , Lecoeuche D , Blanc P , Weill JC , Reynaud CA
Published in: JCI insight, Issue Nov 8, vol 7(21), 2022, Page(s) e157034, ISSN 2379-3708
Publisher: American Association of Clinical Investigation
DOI: 10.1172/jci.insight.157034

A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses

Author(s): Simon Le Gallou, Zhicheng Zhou, Lan-Huong Thai, Remi Fritzen, Alba Verge de los Aires, Jérôme Mégret, Philipp Yu, Daisuke Kitamura, Emmanuelle Bille, Fabiola Tros, Xavier Nassif, Alain Charbit, Sandra Weller, Jean-Claude Weill, Claude-Agnès Reynaud
Published in: The Journal of Experimental Medicine, Issue 215/8, 2018, Page(s) 2035-2053, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20180977

Chronic viral infection promotes efficient germinal center B cell responses

Author(s): Fallet, B., Hao, Y., Florova, M., Cornille, K., Verge de los Aires, A., Girelli Zubani, G., Ertuna, Y., Greiff, V., Menzel, U., Hammad, K., Merkler, D., Reddy, S., Weill, J.-C., Reynaud, C.-A. and Pinschewer, D
Published in: Cell Reports, Issue vol. 30, January 28th, 2020, 2020, Page(s) 1013–1026, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.12.023

IgM memory B cells: specific effectors of innate-like and adaptive responses

Author(s): Jean-Claude Weill, Claude-Agnès Reynaud
Published in: Current Opinion in Immunology, Issue 63, 2020, Page(s) 1-6, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2019.09.003

mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants

Author(s): Sokal, A., Barba-Spaeth, G., Fernández, I., Broketa, M., Azzaoui, I., de La Selle, A., Vandenberghe, A., Fourati, S., Roeser, A., Meola, A., Bouvier-Alias, M., Crickx, E., Languille, L., Michel, M., Godeau, G., Gallien, S., Melica, G., Nguyen, Y., Zarrouk, V., Canoui-Poitrine, F., Noizat-Pirenne, F., Megret, J., Pawlotsky, J.-M., Fillatreau, S., Bruhns, P., Rey, F.A., Weill, J.-C., Reynaud, C.-A.
Published in: Immunity, Issue 54, issue 12, december 14, 2021, Page(s) 1-15, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.09.011

Rituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia

Author(s): Etienne Crickx, Pascal Chappert, Aurélien Sokal, Sandra Weller, Imane Azzaoui, Alexis Vandenberghe, Guillaume Bonnard, Geoffrey Rossi, Tatiana Fadeev, Sébastien Storck, Jehane Fadlallah, Véronique Meignin, Etienne Rivière, Sylvain Audia, Bertrand Godeau, Marc Michel, Jean-Claude Weill, Claude-Agnès Reynaud, Matthieu Mahévas
Published in: Science Translational Medicine, Issue 13/589, 2021, Page(s) eabc3961, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abc3961