Force nanoscopy of staphylococcal biofilms

Project Information

NanoStaph

Grant agreement ID: 693630

DOI 10.3030/693630

Project closed

EC signature date 12 May 2016

Start date 1 October 2016

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 481 437,50

EU contribution € 2 481 437,50

Coordinated by

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium

Publications

Peer reviewed articles (16)

How Microbes Use Force To Control Adhesion

Author(s): Albertus Viljoen, Johann Mignolet, Felipe Viela, Marion Mathelié-Guinlet, Yves F. Dufrêne
Published in: Journal of Bacteriology, Issue 202/12, 2020, ISSN 0021-9193
Publisher: American Society for Microbiology
DOI: 10.1128/jb.00125-20

Staphylococcus aureus binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis

Author(s): Aisling M. Towell, Cécile Feuillie, Pauline Vitry, Thaina M. Da Costa, Marion Mathelié-Guinlet, Sanja Kezic, Orla M. Fleury, Maeve A. McAleer, Yves F. Dufrêne, Alan D. Irvine, Joan A. Geoghegan
Published in: Proceedings of the National Academy of Sciences, Issue 118/1, 2020, Page(s) e2014444118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2014444118

Mechanomicrobiology: how bacteria sense and respond to forces

Author(s): Yves F. Dufrêne, Alexandre Persat
Published in: Nature Reviews Microbiology, Issue 18/4, 2020, Page(s) 227-240, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/s41579-019-0314-2

Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen

Author(s): Marion Mathelié-Guinlet, Felipe Viela, Giampiero Pietrocola, Pietro Speziale, David Alsteens, Yves F. Dufrêne
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19216-8

What makes bacterial pathogens so sticky?

Author(s): Felipe Viela, Marion Mathelié‐Guinlet, Albertus Viljoen, Yves F. Dufrêne
Published in: Molecular Microbiology, Issue 113/4, 2020, Page(s) 683-690, ISSN 0950-382X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/mmi.14448

Binding Strength of Gram-Positive Bacterial Adhesins

Author(s): Yves F. Dufrêne, Albertus Viljoen
Published in: Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2020.01457

Stress-Induced Catch-Bonds to Enhance Bacterial Adhesion

Author(s): Marion Mathelié-Guinlet, Felipe Viela, David Alsteens, Yves F. Dufrêne
Published in: Trends in Microbiology, Issue 29/4, 2021, Page(s) 286-288, ISSN 0966-842X
Publisher: Elsevier BV
DOI: 10.1016/j.tim.2020.11.009

Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC

Author(s): Cécile Feuillie, Cécile Formosa-Dague, Leanne M. C. Hays, Ophélie Vervaeck, Sylvie Derclaye, Marian P. Brennan, Timothy J. Foster, Joan A. Geoghegan, Yves F. Dufrêne
Published in: Proceedings of the National Academy of Sciences, Issue 114/14, 2017, Page(s) 3738-3743, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1616805114

Fibrinogen Activates the Capture of Human Plasminogen by Staphylococcal Fibronectin-Binding Proteins

Author(s): Philippe Herman-Bausier, Giampiero Pietrocola, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne
Published in: mBio, Issue 8/5, 2017, ISSN 2150-7511
Publisher: -
DOI: 10.1128/mbio.01067-17

Single-Cell and Single-Molecule Analysis Unravels the Multifunctionality of the Staphylococcus aureus Collagen-Binding Protein Cna

Author(s): Claire Valotteau, Valeria Prystopiuk, Giampiero Pietrocola, Simonetta Rindi, Daniele Peterle, Vincenzo De Filippis, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne
Published in: ACS Nano, Issue 11/2, 2017, Page(s) 2160-2170, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.6b08404

Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin

Author(s): Pauline Vitry, Claire Valotteau, Cécile Feuillie, Simon Bernard, David Alsteens, Joan A. Geoghegan, Yves F. Dufrêne
Published in: mBio, Issue 8/6, 2017, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.01748-17

Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion

Author(s): Philippe Herman-Bausier, Cristina Labate, Aisling M. Towell, Sylvie Derclaye, Joan A. Geoghegan, Yves F. Dufrêne
Published in: Proceedings of the National Academy of Sciences, Issue 115/21, 2018, Page(s) 5564-5569, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1718104115

Live-Cell Nanoscopy in Antiadhesion Therapy

Author(s): Joan A. Geoghegan, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne
Published in: Trends in Microbiology, Issue 25/7, 2017, Page(s) 512-514, ISSN 0966-842X
Publisher: Elsevier BV
DOI: 10.1016/j.tim.2017.04.002

Mechanical Forces Guiding Staphylococcus aureus Cellular Invasion

Author(s): Valeria Prystopiuk, Cécile Feuillie, Philippe Herman-Bausier, Felipe Viela, David Alsteens, Giampiero Pietrocola, Pietro Speziale, Yves F. Dufrêne
Published in: ACS Nano, Issue 12/4, 2018, Page(s) 3609-3622, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b00716

The Molecular Complex between Staphylococcal Adhesin SpsD and Fibronectin Sustains Mechanical Forces in the Nanonewton Range

Author(s): Felipe Viela, Marion Mathelié-Guinlet, Giampiero Pietrocola, Pietro Speziale, Yves F. Dufrêne
Published in: mBio, Issue 11/4, 2020, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.00371-20

Nanomechanics of the molecular complex between staphylococcal adhesin SpsD and elastin

Author(s): Marion Mathelié-Guinlet, Constance Chantraine, Felipe Viela, Giampiero Pietrocola, Pietro Speziale, Yves F. Dufrêne
Published in: Nanoscale, Issue 12/26, 2020, Page(s) 13996-14003, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr02745f

Non-peer reviewed articles (1)

Force matters in hospital-acquired infections

Author(s): Philippe Herman-Bausier, Yves F. Dufrêne
Published in: Science, Issue 359/6383, 2018, Page(s) 1464-1465, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aat3764