polyValent mEsopoRous nanosystem for bone DIseases

Publications

Peer reviewed articles (97)

Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide

Author(s): Anahí Philippart, Natividad Gómez-Cerezo, Daniel Arcos, Antonio J. Salinas, Elena Boccardi, Maria Vallet-Regi, Aldo R. Boccaccini
Published in: Journal of Non-Crystalline Solids, Issue 455, 2017, Page(s) 90-97, ISSN 0022-3093
DOI: 10.1016/j.jnoncrysol.2016.10.031

Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer

Author(s): Rafael R. Castillo, Montserrat Colilla, María Vallet-Regí
Published in: Expert Opinion on Drug Delivery, Issue 14/2, 2016, Page(s) 229-243, ISSN 1742-5247
DOI: 10.1080/17425247.2016.1211637

Tuning mesoporous silica dissolution in physiological environments: a review

Author(s): Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano, María Vallet-Regí
Published in: Journal of Materials Science, Issue 52/15, 2017, Page(s) 8761-8771, ISSN 0022-2461
DOI: 10.1007/s10853-017-0787-1

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Author(s): Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí
Published in: Bioengineering, Issue 4/4, 2017, Page(s) 3, ISSN 2306-5354
DOI: 10.3390/bioengineering4010003

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

Author(s): Rafael R. Castillo, Alejandro Baeza, María Vallet-Regí
Published in: Biomaterials Science, Issue 5/3, 2017, Page(s) 353-377, ISSN 2047-4830
DOI: 10.1039/c6bm00872k

3D scaffold with effective multidrug sequential release against bacteria biofilm

Author(s): Rafaela García-Alvarez, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 49, 2017, Page(s) 113-126, ISSN 1742-7061
DOI: 10.1016/j.actbio.2016.11.028

Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection

Author(s): Lorena Polo, Natividad Gómez-Cerezo, Elena Aznar, José-Luis Vivancos, Félix Sancenón, Daniel Arcos, María Vallet-Regí, Ramón Martínez-Máñez
Published in: Acta Biomaterialia, Issue 50, 2017, Page(s) 114-126, ISSN 1742-7061
DOI: 10.1016/j.actbio.2016.12.025

Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

Author(s): M. Gisbert-Garzaran, D. Lozano, M. Vallet-Regí, M. Manzano
Published in: RSC Advances, Issue 7/1, 2017, Page(s) 132-136, ISSN 2046-2069
DOI: 10.1039/c6ra26771h

Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment

Author(s): Gonzalo Villaverde, Valentina Nairi, Alejandro Baeza, María Vallet-Regí
Published in: Chemistry - A European Journal, Issue 23/30, 2017, Page(s) 7174-7179, ISSN 0947-6539
DOI: 10.1002/chem.201605947

Electron microscopy for inorganic-type drug delivery nanocarriers for antitumoral applications: what does it reveal?

Author(s): A. Baeza, R. R. Castillo, A. Torres-Pardo, J. M. González-Calbet, M. Vallet-Regí
Published in: Journal of Materials Chemistry B, Issue 5/15, 2017, Page(s) 2714-2725, ISSN 2050-7518
DOI: 10.1039/c6tb03062a

Mechanisms of Muscle Weakness Associated with Bone Metastases

Author(s): MIGUEL MANZANO GARCIA, Khalid S. Mohammad, Theresa A. Guise, Maria Vallet-Regi
Published in: International Journal of Cancer and Oncology, Issue 4/2, 2017, Page(s) 1-5, ISSN 2377-0902
DOI: 10.15436/2377-0902.17.1188

Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions

Author(s): María Vallet‐Regí, Miguel Manzano, Leocadio Rodriguez‐Mañas, Marta Checa López, Matti Aapro, Lodovico Balducci
Published in: The Oncologist, Issue 22/3, 2017, Page(s) 335-342, ISSN 1083-7159
DOI: 10.1634/theoncologist.2016-0276

Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration

Author(s): Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone
Published in: Acta Biomaterialia, Issue 55, 2017, Page(s) 493-504, ISSN 1742-7061
DOI: 10.1016/j.actbio.2017.04.012

Prevention of bacterial adhesion to zwitterionic biocompatible mesoporous glasses

Author(s): Sandra Sánchez-Salcedo, Ana García, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 57, 2017, Page(s) 472-486, ISSN 1742-7061
DOI: 10.1016/j.actbio.2017.05.005

Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy

Author(s): Juan L. Paris, Paz de la Torre, M. Victoria Cabañas, Miguel Manzano, Montserrat Grau, Ana I. Flores, María Vallet-Regí
Published in: Nanoscale, Issue 9/17, 2017, Page(s) 5528-5537, ISSN 2040-3364
DOI: 10.1039/c7nr01070b

A novel visible light responsive nanosystem for cancer treatment

Author(s): M. Martínez-Carmona, D. Lozano, A. Baeza, M. Colilla, M. Vallet-Regí
Published in: Nanoscale, Issue 9/41, 2017, Page(s) 15967-15973, ISSN 2040-3364
DOI: 10.1039/c7nr05050j

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO 2 –P 2 O 5 Glasses in Vitro : Insights from Solid-State NMR

Author(s): Renny Mathew, Claudia Turdean-Ionescu, Yang Yu, Baltzar Stevensson, Isabel Izquierdo-Barba, Ana García, Daniel Arcos, María Vallet-Regí, Mattias Edén
Published in: The Journal of Physical Chemistry C, Issue 121/24, 2017, Page(s) 13223-13238, ISSN 1932-7447
DOI: 10.1021/acs.jpcc.7b03469

Janus Mesoporous Silica Nanoparticles for Dual Targeting of Tumor Cells and Mitochondria

Author(s): Victoria López, Maria Rocío Villegas, Verónica Rodríguez, Gonzalo Villaverde, Daniel Lozano, Alejandro Baeza, María Vallet-Regí
Published in: ACS Applied Materials & Interfaces, Issue 9/32, 2017, Page(s) 26697-26706, ISSN 1944-8244
DOI: 10.1021/acsami.7b06906

Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment

Author(s): Marina Martínez-Carmona, Daniel Lozano, Montserrat Colilla, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 65, 2018, Page(s) 393-404, ISSN 1742-7061
DOI: 10.1016/j.actbio.2017.11.007

Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment

Author(s): Daniel Pedraza, Jaime Díez, Isabel-Izquierdo-Barba, Montserrat Colilla, María Vallet-Regí
Published in: Biomedical Glasses, Issue 4/1, 2018, Page(s) 1-12, ISSN 2299-3932
DOI: 10.1515/bglass-2018-0001

Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

Author(s): María Vallet-Regí, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano
Published in: Molecules, Issue 23/1, 2018, Page(s) 47, ISSN 1420-3049
DOI: 10.3390/molecules23010047

Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection

Author(s): Mónica Cicuéndez, Juan C. Doadrio, Ana Hernández, M. Teresa Portolés, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 65, 2018, Page(s) 450-461, ISSN 1742-7061
DOI: 10.1016/j.actbio.2017.11.009

Multifunctional Protocells for Enhanced Penetration in 3D Extracellular Tumoral Matrices

Author(s): María Rocío Villegas, Alejandro Baeza, Achraf Noureddine, Paul N. Durfee, Kimberly S. Butler, Jacob Ongudi Agola, C. Jeffrey Brinker, María Vallet-Regí
Published in: Chemistry of Materials, Issue 30/1, 2017, Page(s) 112-120, ISSN 0897-4756
DOI: 10.1021/acs.chemmater.7b03128

Mesoporous silica nanoparticles decorated with polycationic dendrimers for infection treatment

Author(s): Blanca González, Montserrat Colilla, Jaime Díez, Daniel Pedraza, Marta Guembe, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 68, 2018, Page(s) 261-271, ISSN 1742-7061
DOI: 10.1016/j.actbio.2017.12.041

Lysine-Grafted MCM-41 Silica as an Antibacterial Biomaterial

Author(s): María Villegas, Lorena Garcia-Uriostegui, Ofelia Rodríguez, Isabel Izquierdo-Barba, Antonio Salinas, Guillermo Toriz, María Vallet-Regí, Ezequiel Delgado
Published in: Bioengineering, Issue 4/4, 2017, Page(s) 80, ISSN 2306-5354
DOI: 10.3390/bioengineering4040080

Self-immolative chemistry in nanomedicine

Author(s): M. Gisbert-Garzarán, M. Manzano, M. Vallet-Regí
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 24-31, ISSN 1385-8947
DOI: 10.1016/j.cej.2017.12.098

Interactions between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers

Author(s): Valentina Nairi, Sara Medda, Marco Piludu, Maria Francesca Casula, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 42-50, ISSN 1385-8947
DOI: 10.1016/j.cej.2018.01.011

Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy

Author(s): Sandra Sanchez-Salcedo, Maria Vallet-Regí, Sophia Allaf Shahin, Carlotta A. Glackin, Jeffrey I. Zink
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 114-124, ISSN 1385-8947
DOI: 10.1016/j.cej.2017.12.116

Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells

Author(s): Juan L. Paris, Miguel Manzano, M. Victoria Cabañas, María Vallet-Regí
Published in: Nanoscale, 2018, ISSN 2040-3364
DOI: 10.1039/C8NR00693H

Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)

Author(s): Sandra Sanchez-Salcedo, Gianluca Malavasi, Antonio Salinas, Gigliola Lusvardi, Luca Rigamonti, Ledi Menabue, Maria Vallet-Regi
Published in: Materials, Issue 11/3, 2018, Page(s) 367, ISSN 1996-1944
DOI: 10.3390/ma11030367

Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery

Author(s): Juan L. Paris, Christophoros Mannaris, M. Victoria Cabañas, Robert Carlisle, Miguel Manzano, María Vallet-Regí, Constantin C. Coussios
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 2-8, ISSN 1385-8947
DOI: 10.1016/j.cej.2017.12.051

Reversible nanogate system for Mesoporous Silica Nanoparticles based on Diels-Alder adducts.

Author(s): Rafael R. Castillo, David Henrández-Escobar, Sergio Gómez-Graña, Maria Vallet-Regi
Published in: Chemistry - A European Journal, 2018, ISSN 0947-6539
DOI: 10.1002/chem.201706100

Recent advances in porous nanoparticles for drug delivery in antitumoral applications: inorganic nanoparticles and nanoscale metal-organic frameworks

Author(s): Alejandro Baeza, Daniel Ruiz-Molina, María Vallet-Regí
Published in: Expert Opinion on Drug Delivery, Issue 14/6, 2017, Page(s) 783-796, ISSN 1742-5247
DOI: 10.1080/17425247.2016.1229298

Role of the Short Distance Order in Glass Reactivity

Author(s): María Vallet-Regi, Antonio Salinas
Published in: Materials, Issue 11/3, 2018, Page(s) 415, ISSN 1996-1944
DOI: 10.3390/ma11030415

Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers

Author(s): Eduardo Guisasola, Laura Asín, Lilianne Beola, Jesús M. de la Fuente, Alejandro Baeza, María Vallet-Regí
Published in: ACS Applied Materials & Interfaces, 2018, ISSN 1944-8244
DOI: 10.1021/acsami.8b02398

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Author(s): Valentina Nairi, Silvia Magnolia, Marco Piludu, Mariella Nieddu, Cristian Antonio Caria, Valeria Sogos, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis
Published in: Colloids and Surfaces B: Biointerfaces, 2018, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2018.02.019

Nanoparticles for the treatment of osteoporosis

Author(s): M. Vallet-Regí, P. Mora-Raimundo, M. Manzano
Published in: AIMS Bioengineering, Issue 4/2, 2017, Page(s) 259-274, ISSN 2375-1495
DOI: 10.3934/bioeng.2017.2.259

High glucose alters the secretome of mechanically stimulated osteocyte-like cells affecting osteoclast precursor recruitment and differentiation

Author(s): Marta Maycas, María Teresa Portolés, María Concepción Matesanz, Irene Buendía, Javier Linares, María José Feito, Daniel Arcos, María Vallet-Regí, Lilian I. Plotkin, Pedro Esbrit, Arancha R. Gortázar
Published in: Journal of Cellular Physiology, Issue 232/12, 2017, Page(s) 3611-3621, ISSN 0021-9541
DOI: 10.1002/jcp.25829

Mesoporous silica nanoparticles in nanomedicine applications

Author(s): Miguel Manzano, María Vallet-Regí
Published in: Journal of Materials Science: Materials in Medicine, Issue 29/5, 2018, Page(s) 65, ISSN 0957-4530
DOI: 10.1007/s10856-018-6069-x

ZnO Nanostructures for Drug Delivery and Theranostic Applications

Author(s): Marina Martínez-Carmona, Yurii Gun’ko, María Vallet-Regí
Published in: Nanomaterials, Issue 8/4, 2018, Page(s) 268, ISSN 2079-4991
DOI: 10.3390/nano8040268

Nanotechnological Strategies for Protein Delivery

Author(s): María Rocío Villegas, Alejandro Baeza, María Vallet-Regí
Published in: Molecules, Issue 23/5, 2018, Page(s) 1008, ISSN 1420-3049
DOI: 10.3390/molecules23051008

Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

Author(s): Eduardo Guisasola, Alejandro Baeza, Laura Asín, Jesús M. de la Fuente, María Vallet-Regí
Published in: Small Methods, 2018, Page(s) 1800007, ISSN 2366-9608
DOI: 10.1002/smtd.201800007

Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages

Author(s): N. Gómez-Cerezo, L. Casarrubios, I. Morales, M.J. Feito, M. Vallet-Regí, D. Arcos, M.T. Portolés
Published in: Journal of Colloid and Interface Science, Issue 528, 2018, Page(s) 309-320, ISSN 0021-9797
DOI: 10.1016/j.jcis.2018.05.099

Collagenase nanocapsules: An approach to fibrosis treatment

Author(s): M. Rocío Villegas, Alejandro Baeza, Alicia Usategui, Pablo L Ortiz-Romero, José L. Pablos, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 74, 2018, Page(s) 430-438, ISSN 1742-7061
DOI: 10.1016/j.actbio.2018.05.007

Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia

Author(s): Mónica Cicuéndez, Joana Flores, Helena Oliveira, M. Teresa Portolés, María Vallet-Regí, Mercedes Vila, Iola F. Duarte
Published in: Materials Science and Engineering: C, Issue 91, 2018, Page(s) 340-348, ISSN 0928-4931
DOI: 10.1016/j.msec.2018.05.057

Nanomotors for Nucleic Acid, Proteins, Pollutants and Cells Detection

Author(s): Alejandro Baeza, María Vallet-Regí
Published in: International Journal of Molecular Sciences, Issue 19/6, 2018, Page(s) 1579, ISSN 1422-0067
DOI: 10.3390/ijms19061579

Targeted Chemo-Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment

Author(s): Gonzalo Villaverde, Sergio Gómez-Graña, Eduardo Guisasola, Isabel García, Christoph Hanske, Luis M. Liz-Marzán, Alejandro Baeza, Maria Vallet-Regí
Published in: Particle & Particle Systems Characterization, 2018, Page(s) 1800148, ISSN 0934-0866
DOI: 10.1002/ppsc.201800148

Synthesis, Characterization and Biocompatibility of Mesolamellar Calcium Phosphate Hybrids Prepared by Anionic Surfactant Templating

Author(s): Antonio J. Salinas, José M. Blanco-Bécares, Okan Mersinlioglu, Laura Casarrubios, Daniel Fernández-Villa, María J. Feito, Teresa Portolés, Blanca González, María Vallet-Regí
Published in: ChemistrySelect, Issue 3/24, 2018, Page(s) 6880-6891, ISSN 2365-6549
DOI: 10.1002/slct.201703130

The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses

Author(s): N. Gómez-Cerezo, E. Verron, V. Montouillout, F. Fayon, P. Lagadec, J.M. Bouler, B. Bujoli, D. Arcos, M. Vallet-Regí
Published in: Acta Biomaterialia, 2018, ISSN 1742-7061
DOI: 10.1016/j.actbio.2018.06.036

Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin

Author(s): Rebeca Pérez, Sandra Sanchez-Salcedo, Daniel Lozano, Clara Heras, Pedro Esbrit, María Vallet-Regí, Antonio Salinas
Published in: Nanomaterials, Issue 8/8, 2018, Page(s) 592, ISSN 2079-4991
DOI: 10.3390/nano8080592

Features of aminopropyl modified mesoporous silica nanoparticles. Implications on the active targeting capability

Author(s): M.V. Cabañas, D. Lozano, A. Torres-Pardo, C. Sobrino, J. González-Calbet, D. Arcos, M. Vallet-Regí
Published in: Materials Chemistry and Physics, Issue 220, 2018, Page(s) 260-269, ISSN 0254-0584
DOI: 10.1016/j.matchemphys.2018.09.005

Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO

Author(s): Preethi Balasubramanian, Antonio J. Salinas, Sandra Sanchez-Salcedo, Rainer Detsch, Maria Vallet-Regi, Aldo R. Boccaccini
Published in: Journal of Non-Crystalline Solids, Issue 500, 2018, Page(s) 217-224, ISSN 0022-3093
DOI: 10.1016/j.jnoncrysol.2018.07.073

Mesoporous bioactive glasses equipped with stimuli-responsive molecular gates for the controlled delivery of levofloxacin against bacteria

Author(s): Lorena Polo, Natividad Gómez-Cerezo, Alba García-Fernández, Elena Aznar, Jose Luis Vivancos, Daniel Arcos, María Vallet-Regí, Ramón Martínez-Máñez
Published in: Chemistry - A European Journal, 2018, ISSN 0947-6539
DOI: 10.1002/chem.201803301

From proof-of-concept material to PEGylated and modularly targeted ultrasound-responsive mesoporous silica nanoparticles

Author(s): Juan L. Paris, Gonzalo Villaverde, M. Victoria Cabañas, Miguel Manzano, María Vallet-Regí
Published in: Journal of Materials Chemistry B, Issue 6/18, 2018, Page(s) 2785-2794, ISSN 2050-7518
DOI: 10.1039/C8TB00444G

Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery

Author(s): Rafael R. Castillo, Daniel Lozano, María Vallet-Regí
Published in: Bioconjugate Chemistry, Issue 29/11, 2018, Page(s) 3677-3685, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.8b00603

Incorporation and effects of mesoporous SiO2-CaO nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures

Author(s): Laura Casarrubios, Natividad Gómez-Cerezo, María José Feito, María Vallet-Regí, Daniel Arcos, María Teresa Portolés
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 133, 2018, Page(s) 258-268, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2018.10.019

Improved connective integration of a degradable 3D-nano-apatite/agarose scaffold subcutaneously implanted in a rat model

Author(s): Natalio García-Honduvilla, Alejandro Coca, Miguel A Ortega, Cynthia Trejo, Jesús Román, Juan Peña, M Victoria Cabañas, Maria Vallet Regi, Julia Buján
Published in: Journal of Biomaterials Applications, Issue 33/5, 2018, Page(s) 741-752, ISSN 0885-3282
DOI: 10.1177/0885328218810084

Suicide-gene transfection of tumor-tropic placental stem cells employing ultrasound-responsive nanoparticles

Author(s): Juan L. Paris, Paz de la Torre, M. Victoria Cabañas, Miguel Manzano, Ana I. Flores, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 83, 2019, Page(s) 372-378, ISSN 1742-7061
DOI: 10.1016/j.actbio.2018.11.006

Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment

Author(s): I. Izquierdo-Barba, L. Santos-Ruiz, J. Becerra, M.J. Feito, D. Fernández-Villa, M.C. Serrano, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, D. Monopoli, H. Afonso, M.T. Portolés, D. Arcos, M. Vallet-Regí
Published in: Acta Biomaterialia, Issue 83, 2019, Page(s) 456-466, ISSN 1742-7061
DOI: 10.1016/j.actbio.2018.11.017

The Role of Zwitterionic Materials in the Fight against Proteins and Bacteria

Author(s): Montserrat Colilla, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Medicines, Issue 5/4, 2018, Page(s) 125, ISSN 2305-6320
DOI: 10.3390/medicines5040125

Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection

Author(s): Marina Martínez-Carmona, Yurii Gun’ko, María Vallet-Regí
Published in: Pharmaceutics, Issue 10/4, 2018, Page(s) 279, ISSN 1999-4923
DOI: 10.3390/pharmaceutics10040279

Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties

Author(s): Noemí Encinas, Mercedes Angulo, Carlos Astorga, Montserrat Colilla, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 84, 2019, Page(s) 317-327, ISSN 1742-7061
DOI: 10.1016/j.actbio.2018.12.012

Molecular Scaffolds as Double-Targeting Agents For the Diagnosis and Treatment of Neuroblastoma

Author(s): Gonzalo Villaverde, Arantzazu Alfranca, África Gonzalez-Murillo, Gustavo J. Melen, Rafael R. Castillo, Manuel Ramírez, Alejandro Baeza, María Vallet-Regí
Published in: Angewandte Chemie International Edition, 2019, Page(s) 3067-3072, ISSN 1433-7851
DOI: 10.1002/anie.201811691

Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties

Author(s): Juan L. Paris, Nuria Lafuente-Gómez, M. Victoria Cabañas, Jesús Román, Juan Peña, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 86, 2019, Page(s) 441-449, ISSN 1742-7061
DOI: 10.1016/j.actbio.2019.01.013

Ultrasound responsive mesoporous silica nanoparticles for biomedical applications

Author(s): Miguel Manzano, María Vallet-Regí
Published in: Chemical Communications, Issue 55/19, 2019, Page(s) 2731-2740, ISSN 1359-7345
DOI: 10.1039/c8cc09389j

Bioceramics: from bone substitutes to nanoparticles for drug delivery

Author(s): María Vallet-Regí
Published in: Pure and Applied Chemistry, Issue 0/0, 2019, ISSN 0033-4545
DOI: 10.1515/pac-2018-0505

Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: insights into the action mechanisms using quantitative proteomics

Author(s): Sandra Montalvo-Quiros, Guillermo Aragoneses-Cazorla, Laura Garcia-Alcalde, María Vallet-Regí, Blanca González, Jose L. Luque-Garcia
Published in: Nanoscale, Issue 11/10, 2019, Page(s) 4531-4545, ISSN 2040-3364
DOI: 10.1039/c8nr07667g

Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety.

Author(s): Rafael R. Castillo, María Vallet-Regí
Published in: International Journal of Molecular Sciences, Issue 20/4, 2019, Page(s) 929, ISSN 1422-0067
DOI: 10.3390/ijms20040929

Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells

Author(s): C. Heras, S. Sanchez-Salcedo, D. Lozano, J. Peña, P. Esbrit, M. Vallet-Regi, A.J. Salinas
Published in: Acta Biomaterialia, Issue 89, 2019, Page(s) 359-371, ISSN 1742-7061
DOI: 10.1016/j.actbio.2019.03.033

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

Author(s): Rafael R. Castillo, Daniel Lozano, Blanca González, Miguel Manzano, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Expert Opinion on Drug Delivery, 2019, Page(s) 1-25, ISSN 1742-5247
DOI: 10.1080/17425247.2019.1598375

Mesoporous bioactive glass/ɛ-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep

Author(s): N. Gómez-Cerezo, L. Casarrubios, M. Saiz-Pardo, L. Ortega, D. de Pablo, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regí
Published in: Acta Biomaterialia, Issue 90, 2019, Page(s) 393-402, ISSN 1742-7061
DOI: 10.1016/j.actbio.2019.04.019

Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent

Author(s): Nadia Garino, Pasquale Sanvitale, Bianca Dumontel, Marco Laurenti, Montserrat Colilla, Isabel Izquierdo-Barba, Valentina Cauda, Maria Vallet-Regì
Published in: RSC Advances, Issue 9/20, 2019, Page(s) 11312-11321, ISSN 2046-2069
DOI: 10.1039/c8ra10236h

Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment

Author(s): Patricia Mora-Raimundo, Daniel Lozano, Miguel Manzano, María Vallet-Regí
Published in: ACS Nano, Issue 13/5, 2019, Page(s) 5451-5464, ISSN 1936-0851
DOI: 10.1021/acsnano.9b00241

Assembly of Multicomponent Nano-Bioconjugates Composed of Mesoporous Silica Nanoparticles, Proteins, and Gold Nanoparticles

Author(s): Giulia Rossella Delpiano, Maria F. Casula, Marco Piludu, Riccardo Corpino, Pier Carlo Ricci, María Vallet-Regí, Enrico Sanjust, Maura Monduzzi, Andrea Salis
Published in: ACS Omega, Issue 4/6, 2019, Page(s) 11044-11052, ISSN 2470-1343
DOI: 10.1021/acsomega.9b01240

Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment

Author(s): Marina Martínez-Carmona, Isabel Izquierdo-Barba, Montserrat Colilla, María Vallet-Regí
Published in: Acta Biomaterialia, 2019, ISSN 1742-7061
DOI: 10.1016/j.actbio.2019.07.001

Cerium (III) and (IV) containing mesoporous glasses/alginate beads for bone regeneration: Bioactivity, biocompatibility and reactive oxygen species activity

Author(s): E. Varini, S. Sánchez-Salcedo, G. Malavasi, G. Lusvardi, M. Vallet-Regí, A.J. Salinas
Published in: Materials Science and Engineering: C, Issue 105, 2019, Page(s) 109971, ISSN 0928-4931
DOI: 10.1016/j.msec.2019.109971

Mesoporous Silica Nanoparticles for Drug Delivery.

Author(s): Miguel Manzano, María Vallet Regí
Published in: Advanced Functional Materials, 2019, Page(s) 1902634, ISSN 1616-301X
DOI: 10.1002/adfm.201902634

Nanomaterials as Promising Alternative in the Infection Treatment

Author(s): María Vallet-Regí, Blanca González, Isabel Izquierdo-Barba
Published in: International Journal of Molecular Sciences, Issue 20/15, 2019, Page(s) 3806, ISSN 1422-0067
DOI: 10.3390/ijms20153806

Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors.

Author(s): Rafael Alvarez , Sandra Muñoz-Piña, María U. González, Isabel Izquierdo-Barba, Iván Fernández-Martínez, Victor Rico, Daniel Arcos, Aurelio García-Valenzuela, Alberto Palmero, María Vallet-Regi, Agustín R. , González-Elipe, José M. García-Martín
Published in: Nanomaterials, 2019, Page(s) 1217, ISSN 2079-4991
DOI: 10.3390/nano9091217

Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics

Author(s): Juan L. Paris, Alejandro Baeza, María Vallet-Regí
Published in: Expert Opinion on Drug Delivery, Issue 16/10, 2019, Page(s) 1095-1112, ISSN 1742-5247
DOI: 10.1080/17425247.2019.1662786

Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep

Author(s): L. Casarrubios, N. Gómez-Cerezo, S. Sánchez-Salcedo, M.J. Feito, M.C. Serrano, M. Saiz-Pardo, L. Ortega, D. de Pablo, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regí
Published in: Acta Biomaterialia, Issue 101, 2020, Page(s) 544-553, ISSN 1742-7061
DOI: 10.1016/j.actbio.2019.10.033

Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy

Author(s): Juan L. Paris, Gonzalo Villaverde, Sergio Gómez-Graña, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 101, 2020, Page(s) 459-468, ISSN 1742-7061
DOI: 10.1016/j.actbio.2019.11.004

Ultrasound-Activated Nanomaterials for Therapeutics

Author(s): Juan L. Paris, María Vallet-Regí
Published in: Bulletin of the Chemical Society of Japan, Issue 93/2, 2020, Page(s) 220-229, ISSN 0009-2673
DOI: 10.1246/bcsj.20190346

Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration

Author(s): Carlotta Pontremoli, Isabel Izquierdo-Barba, Giorgia Montalbano, María Vallet-Regí, Chiara Vitale-Brovarone, Sonia Fiorilli
Published in: Journal of Colloid and Interface Science, Issue 563, 2020, Page(s) 92-103, ISSN 0021-9797
DOI: 10.1016/j.jcis.2019.12.047

The effect of biomimetic mineralization of 3D-printed mesoporous bioglass scaffolds on physical properties and in vitro osteogenicity

Author(s): M. Natividad Gómez-Cerezo, Daniel Lozano, Daniel Arcos, María Vallet-Regí, Cedryck Vaquette
Published in: Materials Science and Engineering: C, Issue 109, 2020, Page(s) 110572, ISSN 0928-4931
DOI: 10.1016/j.msec.2019.110572

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

Author(s): Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí
Published in: Pharmaceutics, Issue 12/1, 2020, Page(s) 83, ISSN 1999-4923
DOI: 10.3390/pharmaceutics12010083

Substituted hydroxyapatite coatings of bone implants

Author(s): Daniel Arcos, María Vallet-Regí
Published in: Journal of Materials Chemistry B, Issue 8/9, 2020, Page(s) 1781-1800, ISSN 2050-7518
DOI: 10.1039/c9tb02710f

Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery

Author(s): Miguel Gisbert-Garzarán, Julia C. Berkmann, Dimitra Giasafaki, Daniel Lozano, Konstantinos Spyrou, Miguel Manzano, Theodore Steriotis, Georg N. Duda, Katharina Schmidt-Bleek, Georgia Charalambopoulou, María Vallet-Regí
Published in: ACS Applied Materials & Interfaces, Issue 12/13, 2020, Page(s) 14946-14957, ISSN 1944-8244
DOI: 10.1021/acsami.0c01786

Bacteria as Nanoparticles Carrier for Enhancing Penetration in a Tumoral Matrix Model

Author(s): Víctor M. Moreno, Elena Álvarez, Isabel Izquierdo‐Barba, Alejandro Baeza, Juana Serrano‐López, María Vallet‐Regí
Published in: Advanced Materials Interfaces, Issue 7/11, 2020, Page(s) 1901942, ISSN 2196-7350
DOI: 10.1002/admi.201901942

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Author(s): Monica Boffito, Alessandro Torchio, Chiara Tonda-Turo, Rossella Laurano, Miguel Gisbert-Garzarán, Julia C. Berkmann, Claudio Cassino, Miguel Manzano, Georg N. Duda, María Vallet-Regí, Katharina Schmidt-Bleek, Gianluca Ciardelli
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, Page(s) https://www.frontiersin.org/articles/10.3389/fbioe.2020.00384/full, ISSN 2296-4185
DOI: 10.3389/fbioe.2020.00384

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Author(s): Miguel Gisbert-Garzarán, María Vallet-Regí
Published in: Nanomaterials, Issue 10/5, 2020, Page(s) 916, ISSN 2079-4991
DOI: 10.3390/nano10050916

Antimycobacterial Effect of Selenium Nanoparticles on Mycobacterium tuberculosis

Author(s): Hector Estevez, Ainhoa Palacios, David Gil, Juan Anguita, Maria Vallet-Regi, Blanca González, Rafael Prados-Rosales, Jose L. Luque-Garcia
Published in: Frontiers in Microbiology, Issue 11, 2020, Page(s) 800, ISSN 1664-302X
DOI: 10.3389/fmicb.2020.00800

Biomaterials against Bone Infection

Author(s): María Vallet‐Regí, Daniel Lozano, Blanca González, Isabel Izquierdo‐Barba
Published in: Advanced Healthcare Materials, Issue 9/13, 2020, Page(s) 2000310, ISSN 2192-2640
DOI: 10.1002/adhm.202000310

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Author(s): Rafael R. Castillo, Daniel Lozano, María Vallet-Regí
Published in: Pharmaceutics, Issue 12/5, 2020, Page(s) 432, ISSN 1999-4923
DOI: 10.3390/pharmaceutics12050432

Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review

Author(s): Juan L. Paris, María Vallet-Regí
Published in: Pharmaceutics, Issue 12/6, 2020, Page(s) 526, ISSN 1999-4923
DOI: 10.3390/pharmaceutics12060526

Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer

Author(s): Marina Martínez-Carmona, Quy P. Ho, Jérémy Morand, Ana García, Enrique Ortega, Luiza C. S. Erthal, Eduardo Ruiz-Hernandez, M. Dolores Santana, José Ruiz, Maria Vallet-Regí, Yurii K. Gun’ko
Published in: Inorganic Chemistry, Issue 59/14, 2020, Page(s) 10275-10284, ISSN 0020-1669
DOI: 10.1021/acs.inorgchem.0c01436

Development and evaluation of copper-containing mesoporous bioactive glasses for bone defects therapy

Author(s): J. Jiménez-Holguín, S. Sánchez-Salcedo, M. Vallet-Regí, A.J. Salinas
Published in: Microporous and Mesoporous Materials, 2020, Page(s) 110454, ISSN 1387-1811
DOI: 10.1016/j.micromeso.2020.110454