Bile acid, immune-metabolism, lipid and glucose homeostasis

Project Information

ImmunoBile

Grant agreement ID: 694717

DOI 10.3030/694717

Project closed

EC signature date 28 June 2016

Start date 1 September 2016

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

UNIVERSITE DE LILLE
France

Publications

Peer reviewed articles (29)

Hepatic sexual dimorphism - implications for non-alcoholic fatty liver disease.

Author(s): Philippe Lefebvre; Bart Staels
Published in: "Nature Reviews Endocrinology, Nature Publishing Group, 2021, 17 (11), pp.662-670. ⟨10.1038/s41574-021-00538-6⟩", Issue 33, 2021, ISSN 1759-5037
Publisher: Springer Nature
DOI: 10.1038/s41574-021-00538-6

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Author(s): Audrey Deprince; Joel T. Haas; Bart Staels
Published in: ISSN: 2212-8778, Issue 31, 2020, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101092

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

Author(s): Deckmyn, Benjamin; Domenger, Dorothée; Blondel, Chloé; Ducastel, Sarah; Nicolas, Emilie; Dorchies, Emilie; Caron, Emilie; Charton, Julie; Vallez, Emmanuelle; Deprez, Benoit; Annicotte, Jean-Sébastien; LESTAVEL, Sophie; Tailleux, Anne; Magnan, Christophe; Staels, Bart; Bantubungi, Kadiombo
Published in: "Frontiers in Molecular Neuroscience, Frontiers Media, 2022, 14, pp.808603. ⟨10.3389/fnmol.2021.808603⟩", Issue 17, 2022, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.808603

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes.

Author(s): Chávez-Talavera, Oscar; Wargny, Matthieu; Pichelin, Matthieu; Descat, Amandine; Vallez, Emmanuelle; Kouach, Mostafa; Bigot-Corbel, Edith; Joliveau, Marielle; Goossens, Jean-François; Le May, Cédric; Hadjadj, Samy; Hanf, Rémy; Tailleux, Anne; Staels, Bart; Cariou, Bertrand
Published in: https://www.hal.inserm.fr/inserm-02869470, Issue 17, 2020, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2019.154042

Metabolic and innate immune cues merge into a specific inflammatory response via unfolded proteinresponse (UPR)

Author(s): Mogilenko, D. (Denis); Haas, J. (Joël); L'homme, L. (Laurent); Fleury, S. (Sébastien); Quemener, S. (Sandrine); Levavasseur, M. (Matthieu); Becquart, C. (Coralie); Wartelle, J. (Julien); Bogomolova, A. (Alexandra); Pineau, L. (Laurent); Molendi-Coste, O. (Olivier); Lancel, S. (Steve); Dehondt, H. (Hélène); Gheeraert, C. (Céline); Melchior, A. (Aurélie); Dewas, C. (Cédric); Nikitin, A. (Arte
Published in: EISSN: 1097-4172, Issue 33, 2019, ISSN 1097-4172
Publisher: Elsevier
DOI: 10.1016/j.cell.2019.03.018

Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

Author(s): Haas, Joel T.; Vonghia, Luisa; Mogilenko, Denis A.; Verrijken, An; Molendi-Coste, Olivier; Fleury, Sébastien; Deprince, Audrey; Nikitin, Artemii; Woitrain, Eloïse; Ducrocq-Geoffroy, Lucie; Pic, Samuel; Derudas, Bruno; Dehondt, Hélène; Gheeraert, Céline; Van Gaal, Luc; Driessen, Ann; Lefebvre, Philippe; Staels, Bart; Francque, Sven; Dombrowicz, David
Published in: Nature Metabolism, Issue 31, 2019, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-019-0076-1

Hepatic molecular signatures highlight the sexual dimorphism of Non-Alcoholic SteatoHepatitis (NASH)

Author(s): Vandel, Jimmy; Dubois-Chevalier, Julie; Gheeraert, Celine; Derudas, Bruno; Raverdy, Violetta; Thuillier, Dorothée; Van Gaal, Luc; Francque, Sven; Pattou, Francois; Staels, Bart; Eeckhoute, Jérôme; Lefebvre, Philippe
Published in: Hepatology (Baltimore, Md.), Issue 15273350, 2021, ISSN 1527-3350
Publisher: John Wiley & Sons
DOI: 10.1002/hep.31312

Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.

Author(s): J. Gillard, L.A. Clerbaux, M. Nachit, C. Sempoux, B. Staels, L.B. Bindels, A. Tailleux, I.A. Leclercq
Published in: JHEP Reports, Issue 4, 2022, Page(s) 100387, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.10.0387

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.

Author(s): Vanessa Hoguet; Manuel Lasalle; Mathieu Maingot; Geoffroy Dequirez; Rajaa Boulahjar; Florence Leroux; Catherine Piveteau; Adrien Herledan; Alexandre Biela; Julie Dumont; Oscar Chávez-Talavera; Loic Belloy; Isabelle Duplan; Nathalie Hennuyer; Laura Butruille; Sophie Lestavel; Emmanuel Sevin; Maxime Culot; Fabien Gosselet; Bart Staels; Benoit Deprez; Anne Tailleux; Julie Charton
Published in: "Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (3), pp.1593-1610. ⟨10.1021/acs.jmedchem.0c01774⟩", Issue 27, 2021, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c01774

Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology.

Author(s): Vanessa Dubois; Bart Staels; Philippe Lefebvre; Michael P. Verzi; Jérôme Eeckhoute
Published in: https://hal.archives-ouvertes.fr/hal-02953857, Issue 13, 2020, ISSN 2073-4409
Publisher: Basel: MDPI AG
DOI: 10.3390/cells9102185

Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients

Author(s): Margerie, Daniel; Lefebvre, Philippe; Raverdy, Violeta; Schwahn, Uwe; Ruetten, Hartmut; Larsen, Philip; Duhamel, Alain; Labreuche, Julien; Thuillier, Dorothée; Derudas, Bruno; Gheeraert, Céline; Dehondt, Hélène; Dhalluin, Quentin; Alexandre, Jérémy; Caiazzo, Robert; Nesslany, Pamela; Verkindt, Helene; Pattou, François; Staels, Bart
Published in: "BMC Medical Genomics, BioMed Central, 2019, 12 (1), pp.80. ⟨10.1186/s12920-019-0536-1⟩", Issue 17558794, 2019, ISSN 1755-8794
Publisher: BioMed Central
DOI: 10.1186/s12920-019-0536-1

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

Author(s): Bobowski-Gerard, Marie; Zummo, Francesco; Staels, Bart; Lefebvre, Philippe; Eeckhoute, Jérôme
Published in: https://www.hal.inserm.fr/inserm-02154783, Issue 25, 2018, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells7090137

Hypothalamic bile acid-TGR5 signaling protects from obesity.

Author(s): Ashley Castellanos-Jankiewicz; Omar Guzmán-Quevedo; Omar Guzmán-Quevedo; Valérie S. Fénelon; Philippe Zizzari; Carmelo Quarta; Luigi Bellocchio; Anne Tailleux; Julie Charton; Daniela Fernandois; Marcus Henricsson; Catherine Piveteau; Vincent Simon; Camille Allard; Sandrine Quemener; Valentine Guinot; Nathalie Hennuyer; Alessia Perino; Alexia Duveau; Marlène Maitre; Thierry Leste-Lasserre; Sam
Published in: "Cell Metabolism, Elsevier, 2021, Online ahead of print. ⟨10.1016/j.cmet.2021.04.009⟩", Issue 39, 2021, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.04.0099

GIANT : Galaxy-based tool for Interactive ANalysis of Transcriptomic data

Author(s): Jimmy Vandel; Céline Gheeraert; Bart Staels; Jérôme Eeckhoute; Philippe Lefebvre; Julie Dubois-Chevalier
Published in: EISSN: 2045-2322, Issue 34, 2020, Page(s) Springer Nature, ISSN 2073-4409
Publisher: Springer Nature
DOI: 10.1038/s41598-020-76769-w

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction

Author(s): Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-François Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne
Published in: Gut, Issue 67/2, 2018, Page(s) 271-283, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-313316

The logic of transcriptional regulator recruitment architecture at cis -regulatory modules controlling liver functions

Author(s): Julie Dubois-Chevalier, Vanessa Dubois, Hélène Dehondt, Parisa Mazrooei, Claire Mazuy, Aurélien A. Sérandour, Céline Gheeraert, Penderia Guillaume, Eric Baugé, Bruno Derudas, Nathalie Hennuyer, Réjane Paumelle, Guillemette Marot, Jason S. Carroll, Mathieu Lupien, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Published in: Genome Research, Issue 27/6, 2017, Page(s) 985-996, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.217075.116

Alternative macrophages in atherosclerosis: not always protective!

Author(s): Benoit Pourcet, Bart Staels
Published in: Journal of Clinical Investigation, Issue 128/3, 2018, Page(s) 910-912, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI120123

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects

Author(s): Vanessa Legry, Sven Francque, Joel T Haas, An Verrijken, Sandrine Caron, Oscar Chávez-Talavera, Emmanuelle Vallez, Luisa Vonghia, Eveline Dirinck, Ann Verhaegen, Mostafa Kouach, Sophie Lestavel, Philippe Lefebvre, Luc Van Gaal, Anne Tailleux, Réjane Paumelle, Bart Staels
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 102/10, 2017, Page(s) 3783-3794, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/JC.2017-01397

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

Author(s): Benoit Pourcet, Mathilde Zecchin, Lise Ferri, Justine Beauchamp, Sadicha Sitaula, Cyrielle Billon, Stéphane Delhaye, Jonathan Vanhoutte, Alicia Mayeuf-Louchart, Quentin Thorel, Joel T. Haas, Jérome Eeckhoute, David Dombrowicz, Christian Duhem, Alexis Boulinguiez, Steve Lancel, Yasmine Sebti, Thomas P. Burris, Bart Staels, Hélène M. Duez
Published in: Gastroenterology, Issue 154/5, 2018, Page(s) 1449-1464.e20, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.12.019

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

Author(s): Maheul Ploton, Claire Mazuy, Céline Gheeraert, Vanessa Dubois, Alexandre Berthier, Julie Dubois-Chevalier, Xavier Maréchal, Kadiombo Bantubungi, Hélène Diemer, Sarah Cianférani, Jean-Marc Strub, Audrey Helleboid-Chapman, Jérôme Eeckhoute, Bart Staels, Philippe Lefebvre
Published in: Journal of Hepatology, Issue 69/5, 2018, Page(s) 1099-1109, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2018.06.022

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Author(s): Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, Loïc Belloy, Sophie Lestavel, Emmanuelle Vallez, Emilie Dorchies, Isabelle Duplan, Emmanuel Sevin, Maxime Culot, Fabien Gosselet, Rajaa Boulahjar, Adrien Herledan, Bart Staels, Benoit Deprez, Anne Tailleux, Julie Charton
Published in: Journal of Medicinal Chemistry, Issue 60/10, 2017, Page(s) 4185-4211, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01873

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

Author(s): Oscar Chávez-Talavera, Anne Tailleux, Philippe Lefebvre, Bart Staels
Published in: Gastroenterology, Issue 152/7, 2017, Page(s) 1679-1694.e3, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.01.055

IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women

Author(s): Denis A. Mogilenko; Denis A. Mogilenko; R. Caiazzo; Laurent L'Homme; Laurent Pineau; Violeta Raverdy; Jerome Noulette; Bruno Derudas; François Pattou; Bart Staels; David Dombrowicz
Published in: EISSN: 0307-0565, Issue 11, 2021, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-021-00826-1

Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid.

Author(s): Jan Freark de Boer; Hilde D. de Vries; Hilde D. de Vries; Anna Palmiotti; Rumei Li; Marwah Doestzada; Joanne A Hoogerland; Jingyuan Fu; Anouk M. La Rose; Marit Westerterp; Niels L. Mulder; Milaine V. Hovingh; Martijn Koehorst; Niels J. Kloosterhuis; Justina C. Wolters; Vincent W. Bloks; Joel T. Haas; David Dombrowicz; Bart Staels; Bart van de Sluis; Folkert Kuipers
Published in: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1045-1069 (2021), Issue 50, 2021, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2020.12.004

Preview Cell Metabolism, deadline February 7th, 2020 Title Microbiome modulation of host's adaptive immunity through bile acid modification

Author(s): Kuipers, F. (Folkert); Freark De Boer, J. (Jan); Staels, B. (Bart)
Published in: "Cell Metabolism, Elsevier, 2020, 31 (3), pp.445-447. ⟨10.1016/j.cmet.2020.02.006⟩", Issue 13, 2020, ISSN 1932-7420
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.02.006

Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

Author(s): Bougarne, Nadia; Weyers, Basiel; Desmet, Sofie J; Deckers, Julie; Ray, David W; Staels, Bart; De Bosscher, Karolien
Published in: "Endocrine reviews, Endocrine Society, 2018, 39 (5), pp.760-802. ⟨10.1210/er.2018-00064⟩", Issue 32, 2018, ISSN 1945-7189
Publisher: Endocrine Society
DOI: 10.1210/er.2018-00064

what do the human studies tell?

Author(s): Oscar Chávez-Talavera; Joel T. Haas; Guillaume Grzych; Anne Tailleux; Bart Staels
Published in: ISSN: 0957-9672, Issue 12, 2019, ISSN 0957-9672
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000597

The circadian clock and liver function in health and disease

Author(s): Atish Mukherji; Shannon M. Bailey; Bart Staels; Thomas F. Baumert
Published in: "Journal of Hepatology, Elsevier, 2019, 71 (1), pp.200-211. ⟨10.1016/j.jhep.2019.03.020⟩", Issue 46, 2019, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.020

NASH-related increases in plasma bile acid levels depend on insulin resistance.

Author(s): Guillaume Grzych; Oscar Chávez-Talavera; Amandine Descat; Dorothée Thuillier; An Verrijken; Mostafa Kouach; Vanessa Legry; Hélène Verkindt; Violeta Raverdy; Benjamin Legendre; R. Caiazzo; Luc Van Gaal; Jean-François Goossens; Réjane Paumelle; Sven Francque; François Pattou; Joel T. Haas; Anne Tailleux; Bart Staels
Published in: JHEP Reports, Issue 38, 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2020.100222