Role of autonomous B cell receptor signalling and external antigen in the pathogenesis of chronic lymphocytic leukaemia (CLL)

Project Information

Autonomous CLL-BCRs

Grant agreement ID: 694992

DOI

10.3030/694992

Project closed

EC signature date 20 June 2016

Start date 1 November 2016

End date 31 October 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 256 250,00

EU contribution

€ 2 256 250,00

Coordinated by

UNIVERSITAET ULM
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

The determinants of B cell receptor signaling as prototype molecular biomarkers of leukemia

Author(s): Antonella Nicolò, Alexandra T. Linder, Hassan Jumaa and Palash C. Maity
Published in: Frontiers in Oncology, 2021, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.771669

B-cell receptor isotypes differentially associate with cell signaling, kinetics, and outcome in chronic lymphocytic leukemia

Author(s): Andrea N Mazzarello, Eva Gentner-Göbel, Marcus Dühren-von Minden, Tatyana N Tarasenko, Antonella Nicolò, Gerardo Ferrer, Stefano Vergani, Yun Liu, Davide Bagnara, Kanti R Rai, Jan A Burger, Peter J McGuire, Palash C Maity, Hassan Jumaa, Nicholas Chiorazzi
Published in: Journal of Clinical Investigation, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci149308

Primary Immune Responses and Affinity Maturation Are Controlled by IgD

Author(s): Timm Amendt, Omar El Ayoubi, Alexandra T. Linder, Gabriele Allies, Marc Young, Corinna S. Setz, Hassan Jumaa
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers of Immunology
DOI: 10.3389/fimmu.2021.709240

Defective Allelic Exclusion by IgD in the Absence of Autoantigen

Author(s): Valerio Renna, Elena Surova, Ahmad Khadour, Moumita Datta, Timm Amendt, Elias Hobeika and Hassan Jumaa
Published in: The Journal of Immunology, 2021, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2100726

PI3K induces B-cell development and regulates B cell identity

Author(s): Hend Abdelrasoul, Markus Werner, Corinna S. Setz, Klaus Okkenhaug, Hassan Jumaa
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-19460-5

Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor

Author(s): Joseena Iype, Moumita Datta, Ahmad Khadour, Rudolf Übelhart, Antonella Nicolò, Tim Rollenske, Marcus Dühren-von Minden, Hedda Wardemann, Palash C. Maity, Hassan Jumaa
Published in: The Journal of Immunology, Issue 202/5, 2019, Page(s) 1417-1427, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1800690

Isotype Specific Assembly of B Cell Antigen Receptors and Synergism With Chemokine Receptor CXCR4

Author(s): Palash C. Maity, Moumita Datta, Antonella Nicolò, Hassan Jumaa
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.02988

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

Author(s): Ameera Alsadeq, Lennart Lenk, Anila Vadakumchery, Antony Cousins, Christian Vokuhl, Ahmad Khadour, Fotini Vogiatzi, Felix Seyfried, Lueder-Hinrich Meyer, Gunnar Cario, Elias Hobeika, Klaus-Michael Debatin, Christina Halsey, Martin Schrappe, Denis M. Schewe, Hassan Jumaa
Published in: Blood, Issue 132/15, 2018, Page(s) 1614-1617, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2018-04-844209

PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis

Author(s): Corinna S. Setz, Eva Hug, Ahmad Khadour, Hend Abdelrasoul, Mayas Bilal, Elias Hobeika, Hassan Jumaa
Published in: Cell Reports, Issue 24/2, 2018, Page(s) 391-405, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.06.035

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

Author(s): Katharina Imkeller, Stephen W. Scally, Alexandre Bosch, Gemma Pidelaserra Martí, Giulia Costa, Gianna Triller, Rajagopal Murugan, Valerio Renna, Hassan Jumaa, Peter G. Kremsner, B. Kim Lee Sim, Stephen L. Hoffman, Benjamin Mordmüller, Elena A. Levashina, Jean-Philippe Julien, Hedda Wardemann
Published in: Science, Issue 360/6395, 2018, Page(s) 1358-1362, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar5304

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

Author(s): Gang Xiao, Lai N. Chan, Lars Klemm, Daniel Braas, Zhengshan Chen, Huimin Geng, Qiuyi Chen Zhang, Ali Aghajanirefah, Kadriye Nehir Cosgun, Teresa Sadras, Jaewoong Lee, Tamara Mirzapoiazova, Ravi Salgia, Thomas Ernst, Andreas Hochhaus, Hassan Jumaa, Xiaoyan Jiang, David M. Weinstock, Thomas G. Graeber, Markus Müschen
Published in: Cell, Issue 173/2, 2018, Page(s) 470-484.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.02.048

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

Author(s): Claudia Minici, Maria Gounari, Rudolf Übelhart, Lydia Scarfò, Marcus Dühren-von Minden, Dunja Schneider, Alpaslan Tasdogan, Alabbas Alkhatib, Andreas Agathangelidis, Stavroula Ntoufa, Nicholas Chiorazzi, Hassan Jumaa, Kostas Stamatopoulos, Paolo Ghia, Massimo Degano
Published in: Nature Communications, Issue 8, 2017, Page(s) 15746, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15746

Pten controls B‐cell responsiveness and germinal center reaction by regulating the expression of IgD BCR

Author(s): Corinna S Setz, Ahmad Khadour, Valerio Renna, Joseena Iype, Eva Gentner, Xiaocui He, Moumita Datta, Marc Young, Lars Nitschke, Jürgen Wienands, Palash C Maity, Michael Reth, Hassan Jumaa
Published in: The EMBO Journal, 2019, Page(s) e100249, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100249

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

Author(s): Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk, Ahmad Khadour, Marc Young, Omar El Ayoubi, Fotini Vogiatzi, Markus Krämer, Vera Schmid, Zhengshan Chen, Yasar Yousafzai, Gunnar Cario, Martin Schrappe, Markus Müschen, Christina Halsey, Medhanie A. Mulaw, Denis M. Schewe, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16927-w

IGLV3-21 * 01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

Author(s): Palash C. Maity, Mayas Bilal, Marvyn T. Koning, Marc Young, Cornelis A. M. van Bergen, Valerio Renna, Antonella Nicolò, Moumita Datta, Eva Gentner-Göbel, Rob S. Barendse, Sebastiaan F. Somers, Ruben A. L. de Groen, Joost S. P. Vermaat, Daniela Steinbrecher, Christof Schneider, Eugen Tausch, Tamara Bittolo, Riccardo Bomben, Andrea Nicola Mazzarello, Giovanni del Poeta, Wilma G. M. Kroes, J. Tom v
Published in: Proceedings of the National Academy of Sciences, Issue 117/8, 2020, Page(s) 4320-4327, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1913810117