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Noninvasive Manipulation of Gating in Ion Channels

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Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers

Author(s): Laura-Marie Winterstein, Kerri Kukovetz, Oliver Rauh, Daniel L. Turman, Christian Braun, Anna Moroni, Indra Schroeder, Gerhard Thiel
Published in: The Journal of General Physiology, 2018, Page(s) jgp.201711904, ISSN 0022-1295
DOI: 10.1085/jgp.201711904

Extended beta distributions open the access to fast gating in bilayer experiments-assigning the voltage-dependent gating to the selectivity filter

Author(s): Oliver Rauh, Ulf-Peter Hansen, Sebastian Mach, Andreas J.W. Hartel, Kenneth L. Shepard, Gerhard Thiel, Indra Schroeder
Published in: FEBS Letters, Issue 591/23, 2017, Page(s) 3850-3860, ISSN 0014-5793
DOI: 10.1002/1873-3468.12898

Fusicoccin Activates KAT1 Channels by Stabilizing their Interaction with 14-3-3- Proteins

Author(s): Andrea saponaro, Alessandro Porro, Antonio Chaves-Sanjuan, Marco Nardini, Oliver Rauh, Gerhard Thiel, Anna Moroni
Published in: The Plant Cell, 2017, Page(s) tpc.00375.2017, ISSN 1040-4651
DOI: 10.1105/tpc.17.00375

Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K + Channels

Author(s): Oliver Rauh, Martin Urban, Leonhard M. Henkes, Tobias Winterstein, Timo Greiner, James L. Van Etten, Anna Moroni, Stefan M. Kast, Gerhard Thiel, Indra Schroeder
Published in: Journal of the American Chemical Society, Issue 139/22, 2017, Page(s) 7494-7503, ISSN 0002-7863
DOI: 10.1021/jacs.7b01158

A reduced mechanical model for cAMP-modulated gating in HCN channels

Author(s): Stephanie Weißgraeber, Andrea Saponaro, Gerhard Thiel, Kay Hamacher
Published in: Scientific Reports, Issue 7, 2017, Page(s) 40168, ISSN 2045-2322
DOI: 10.1038/srep40168

Site-specific ion occupation in the selectivity filter causes voltage-dependent gating in a viral K+ channel

Author(s): O. Rauh, U. P. Hansen, D. D. Scheub, G. Thiel, I. Schroeder
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-28751-w

Genes for Membrane Transport Proteins: Not So Rare in Viruses

Author(s): Timo Greiner, Anna Moroni, James Van Etten, Gerhard Thiel
Published in: Viruses, Issue 10/9, 2018, Page(s) 456, ISSN 1999-4915
DOI: 10.3390/v10090456

A light-gated potassium channel for sustained neuronal inhibition

Author(s): Laura Alberio, Andrea Locarno, Andrea Saponaro, Edoardo Romano, Valérie Bercier, Shahad Albadri, Federica Simeoni, Silvia Moleri, Silvia Pelucchi, Alessandro Porro, Elena Marcello, Noemi Barsotti, Kerri Kukovetz, Arjen J. Boender, Andrea Contestabile, Shizhen Luo, Aubin Moutal, Yingshi Ji, Giulia Romani, Monica Beltrame, Filippo Del Bene, Monica Di Luca, Rajesh Khanna, Henry M. Colecraft, Massimo
Published in: Nature Methods, Issue 15/11, 2018, Page(s) 969-976, ISSN 1548-7091
DOI: 10.1038/s41592-018-0186-9

Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel

Author(s): Christine Gross, Andrea Saponaro, Bina Santoro, Anna Moroni, Gerhard Thiel, Kay Hamacher
Published in: Journal of Biological Chemistry, Issue 293/33, 2018, Page(s) 12908-12918, ISSN 0021-9258
DOI: 10.1074/jbc.RA118.002139

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Author(s): Andrea Saponaro, Francesca Cantini, Alessandro Porro, Annalisa Bucchi, Dario DiFrancesco, Vincenzo Maione, Chiara Donadoni, Bianca Introini, Pietro Mesirca, Matteo E Mangoni, Gerhard Thiel, Lucia Banci, Bina Santoro, Anna Moroni
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/eLife.35753