Noninvasive Manipulation of Gating in Ion Channels

Informazioni relative al progetto

noMAGIC

ID dell’accordo di sovvenzione: 695078

DOI 10.3030/695078

Progetto chiuso

Data della firma CE 30 Maggio 2016

Data di avvio 1 Settembre 2016

Data di completamento 31 Agosto 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 409 209,00

Contributo UE € 2 409 209,00

Coordinato da

UNIVERSITA DEGLI STUDI DI MILANO
Italy

Pubblicazioni

Peer reviewed articles (19)

A small viral potassium ion channel with an inherent inward rectification

Autori: Denise Eckert, Tobias Schulze, Julian Stahl, Oliver Rauh, James L Van Etten, Brigitte Hertel, Indra Schroeder, Anna Moroni, Gerhard Thiel
Pubblicato in: Channels, Numero 13/1, 2019, Pagina/e 124-135, ISSN 1933-6950
Editore: Landes Bioscience
DOI: 10.1080/19336950.2019.1605813

Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes

Autori: Andreas J. W. Hartel, Peijie Ong, Indra Schroeder, M. Hunter Giese, Siddharth Shekar, Oliver B. Clarke, Ran Zalk, Andrew R. Marks, Wayne A. Hendrickson, Kenneth L. Shepard
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 115/8, 2018, Pagina/e E1789-E1798, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1712313115

Codon Bias Can Determine Sorting of a Potassium Channel Protein

Autori: Anja J. Engel, Marina Kithil, Markus Langhans, Oliver Rauh, Matea Cartolano, James L. Van Etten, Anna Moroni, Gerhard Thiel
Pubblicato in: Cells, Numero 10/5, 2021, Pagina/e 1128, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10051128

Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That Infect Chlorella heliozoae

Autori: Carter R. Murry, Irina V. Agarkova, Jayadri S. Ghosh, Fiona C. Fitzgerald, Roger M. Carlson, Brigitte Hertel, Kerri Kukovetz, Oliver Rauh, Gerhard Thiel, James L. Van Etten
Pubblicato in: Viruses, Numero 12/6, 2020, Pagina/e 678, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060678

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

Autori: Alessandro Porro, Andrea Saponaro, Federica Gasparri, Daniel Bauer, Christine Gross, Matteo Pisoni, Gerardo Abbandonato, Kay Hamacher, Bina Santoro, Gerhard Thiel, Anna Moroni
Pubblicato in: eLife, Numero 8, 2019, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.49672

Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers

Autori: Laura-Marie Winterstein, Kerri Kukovetz, Oliver Rauh, Daniel L. Turman, Christian Braun, Anna Moroni, Indra Schroeder, Gerhard Thiel
Pubblicato in: The Journal of General Physiology, 2018, Pagina/e jgp.201711904, ISSN 0022-1295
Editore: Rockefeller University Press
DOI: 10.1085/jgp.201711904

Extended beta distributions open the access to fast gating in bilayer experiments-assigning the voltage-dependent gating to the selectivity filter

Autori: Oliver Rauh, Ulf-Peter Hansen, Sebastian Mach, Andreas J.W. Hartel, Kenneth L. Shepard, Gerhard Thiel, Indra Schroeder
Pubblicato in: FEBS Letters, Numero 591/23, 2017, Pagina/e 3850-3860, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.12898

Fusicoccin Activates KAT1 Channels by Stabilizing their Interaction with 14-3-3- Proteins

Autori: Andrea saponaro, Alessandro Porro, Antonio Chaves-Sanjuan, Marco Nardini, Oliver Rauh, Gerhard Thiel, Anna Moroni
Pubblicato in: The Plant Cell, 2017, Pagina/e tpc.00375.2017, ISSN 1040-4651
Editore: American Society of Plant Biologists
DOI: 10.1105/tpc.17.00375

Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K + Channels

Autori: Oliver Rauh, Martin Urban, Leonhard M. Henkes, Tobias Winterstein, Timo Greiner, James L. Van Etten, Anna Moroni, Stefan M. Kast, Gerhard Thiel, Indra Schroeder
Pubblicato in: Journal of the American Chemical Society, Numero 139/22, 2017, Pagina/e 7494-7503, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b01158

A reduced mechanical model for cAMP-modulated gating in HCN channels

Autori: Stephanie Weißgraeber, Andrea Saponaro, Gerhard Thiel, Kay Hamacher
Pubblicato in: Scientific Reports, Numero 7, 2017, Pagina/e 40168, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep40168

Site-specific ion occupation in the selectivity filter causes voltage-dependent gating in a viral K+ channel

Autori: O. Rauh, U. P. Hansen, D. D. Scheub, G. Thiel, I. Schroeder
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-28751-w

Genes for Membrane Transport Proteins: Not So Rare in Viruses

Autori: Timo Greiner, Anna Moroni, James Van Etten, Gerhard Thiel
Pubblicato in: Viruses, Numero 10/9, 2018, Pagina/e 456, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10090456

A light-gated potassium channel for sustained neuronal inhibition

Autori: Laura Alberio, Andrea Locarno, Andrea Saponaro, Edoardo Romano, Valérie Bercier, Shahad Albadri, Federica Simeoni, Silvia Moleri, Silvia Pelucchi, Alessandro Porro, Elena Marcello, Noemi Barsotti, Kerri Kukovetz, Arjen J. Boender, Andrea Contestabile, Shizhen Luo, Aubin Moutal, Yingshi Ji, Giulia Romani, Monica Beltrame, Filippo Del Bene, Monica Di Luca, Rajesh Khanna, Henry M. Colecraft, Massimo
Pubblicato in: Nature Methods, Numero 15/11, 2018, Pagina/e 969-976, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-018-0186-9

Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel

Autori: Christine Gross, Andrea Saponaro, Bina Santoro, Anna Moroni, Gerhard Thiel, Kay Hamacher
Pubblicato in: Journal of Biological Chemistry, Numero 293/33, 2018, Pagina/e 12908-12918, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA118.002139

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Autori: Andrea Saponaro, Francesca Cantini, Alessandro Porro, Annalisa Bucchi, Dario DiFrancesco, Vincenzo Maione, Chiara Donadoni, Bianca Introini, Pietro Mesirca, Matteo E Mangoni, Gerhard Thiel, Lucia Banci, Bina Santoro, Anna Moroni
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.35753

Photolithographic Fabrication of Micro Apertures in Dry Film Polymer Sheets for Channel Recordings in Planar Lipid Bilayers

Autori: Mario El Khoury, Tobias Winterstein, Wadim Weber, Viktor Stein, Helmut F. Schlaak, Gerhard Thiel
Pubblicato in: The Journal of Membrane Biology, Numero 252/2-3, 2019, Pagina/e 173-182, ISSN 0022-2631
Editore: Springer Verlag
DOI: 10.1007/s00232-019-00062-9

Structural basis for ion selectivity in TMEM175 K+ channels.

Autori: Janine D. Brunner; Roman P. Jakob; Tobias Schulze; Yvonne Neldner; Anna Moroni; Gerhard Thiel; Timm Maier; Stephan Schenck
Pubblicato in: eLife, Numero 1, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.5167/uzh-186964

A Functional K+ Channel from Tetraselmis Virus 1, a Member of the Mimiviridae

Autori: Kerri Kukovetz, Brigitte Hertel, Christopher R. Schvarcz, Andrea Saponaro, Mirja Manthey, Ulrike Burk, Timo Greiner, Grieg F. Steward, James L. Van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh
Pubblicato in: Viruses, Numero 12/10, 2020, Pagina/e 1107, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12101107

High bandwidth approaches in nanopore and ion channel recordings - A tutorial review

Autori: Andreas J.W. Hartel, Siddharth Shekar, Peijie Ong, Indra Schroeder, Gerhard Thiel, Kenneth L. Shepard
Pubblicato in: Analytica Chimica Acta, Numero 1061, 2019, Pagina/e 13-27, ISSN 0003-2670
Editore: Elsevier BV
DOI: 10.1016/j.aca.2019.01.034