Time Resolved THz Calorimetry explores Molecular Recognition Processes

Project Information

THZCALORIMETRY

Grant agreement ID: 695437

DOI 10.3030/695437

Project closed

EC signature date 29 June 2016

Start date 1 October 2016

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

RUHR-UNIVERSITAET BOCHUM
Germany

Publications

Peer reviewed articles (36)

Molecular fingerprints of hydrophobicity at aqueous interfaces from theory and vibrational spectroscopies

Author(s): Simone Pezzotti, Alessandra Serva, Federico Sebastiani, Flavio Siro Brigiano, Daria Ruth Galimberti, Louis Potier, Serena Alfarano, Gerhard Schwaab, Martina Havenith, Marie-Pierre Gaigeot
Published in: The Journal of Physical Chemistry Letters, Issue 12, 2021, Page(s) 3827−3836, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.1021/acs.jpclett.1c00257

Water Solvation of Charged and Neutral Gold Nanoparticles

Author(s): Fabio Novelli, Miguel Bernal Lopez, Gerhard Schwaab, Beatriz Roldan Cuenya, Martina Havenith
Published in: The Journal of Physical Chemistry B, Issue 123/30, 2019, Page(s) 6521-6528, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.9b02358

Intravital imaging of vascular anomalies and extracellular matrix remodeling in orthotopic pancreatic tumors

Author(s): Filip Bochner, Vishnu Mohan, Assaf Zinger, Ofra Golani, Avi Schroeder, Irit Sagi, Michal Neeman
Published in: International Journal of Cancer, Issue 146/8, 2019, Page(s) 2209-2217, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32759

Conformation-specific inhibitory anti-MMP-7 monoclonal antibody sensitizes pancreatic ductal adenocarcinoma cells to chemotherapeutic cell kill

Author(s): Vishnu Mohan,Jean P. Gaffney, Inna Solomonov, Maxim Levin, Mordehay Klepfish, Sophia Akbareian, Barbara Grünwald, Orly Dym, Miriam Eisenstein, Kenneth H. Yu, David P. Kelsen,Achim Krüger, Dylan R. Edwards, Irit Sagi
Published in: Cancers, Issue 13/7, 2021, Page(s) 1679, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071679

Emerging roles of ECM remodeling processes in cancer

Author(s): Vishnu Mohan, Alakesh Das, Irit Sagi
Published in: Seminars in Cancer Biology, Issue 62, 2020, Page(s) 192-200, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2019.09.004

Solvent dynamics play a decisive role in the complex formation of biologically relevant redox proteins

Author(s): Ellen M. Adams, Oliver Lampret, Benedikt König, Thomas Happe, Martina Havenith
Published in: Physical Chemistry Chemical Physics, Issue 22/14, 2020, Page(s) 7451-7459, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cp00267d

Strong Anisotropy in Liquid Water upon Librational Excitation Using Terahertz Laser Fields

Author(s): Fabio Novelli, Luis Ruiz Pestana, Kochise C. Bennett, Federico Sebastiani, Ellen M. Adams, Nikolas Stavrias, Thorsten Ockelmann, Alejandro Colchero, Claudius Hoberg, Gerhard Schwaab, Teresa Head-Gordon, Martina Havenith
Published in: The Journal of Physical Chemistry B, Issue 124/24, 2020, Page(s) 4989-5001, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.0c02448

Next generation matrix metalloproteinase inhibitors — Novel strategies bring new prospects

Author(s): Maxim Levin, Yael Udi, Inna Solomonov, Irit Sagi
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1864/11, 2017, Page(s) 1927-1939, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/j.bbamcr.2017.06.009

Terahertz pump-probe of liquid water at 12.3 THz

Author(s): Fabio Novelli, Claudius Hoberg, Ellen M Adams, J Michael Klopf, Martina Havenith
Published in: Physical Chemistry Chemical Physics, Issue 24, 2021, Page(s) 653-665, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cp03207k

Local mutations can serve as a game changer for global protein solvent interaction

Author(s): Ellen M. Adams, Simone Pezzotti, Jonas Ahlers, Maximilian Rüttermann, Maxim Levin, Adi Goldenzweig, Yoav Peleg, Sarel J. Fleishman, Irit Sagi, Martina Havenith
Published in: JACS Au, Issue 1/7, 2021, Page(s) 1076–1085, ISSN 2691-3704
Publisher: Washington DC: American Chemical Society
DOI: 10.1021/jacsau.1c00155

Kartierung des Hydratwassers um Alkoholketten mittels THz‐Kalorimetrie

Author(s): Fabian Böhm, Gerhard Schwaab, Martina Havenith
Published in: Angewandte Chemie, Issue 129/33, 2017, Page(s) 10113-10117, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201612162

Probing Local Electrostatics of Glycine in Aqueous Solution by THz Spectroscopy

Author(s): Federico Sebastiani, Chun Yu Ma, Sarah Funke, Alexander Bäumer, Dominique Decka, Claudius Hoberg, Alexander Esser, Harald Forbert, Gerhard Schwaab, Dominik Marx, Martina Havenith
Published in: Angewandte Chemie International Edition, Issue 60/7, 2021, Page(s) 3768-3772, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202014133

Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression

Author(s): Alakesh Das, Vishnu Mohan, Venkat Raghavan Krishnaswamy, Inna Solomonov, Irit Sagi
Published in: Cancer and Metastasis Reviews, Issue 38/3, 2019, Page(s) 455-468, ISSN 0167-7659
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10555-019-09813-5

Size dependence of hydrophobic hydration at electrified gold/water interfaces

Author(s): Alessandra Serva, Mathieu Salanne, Martina Havenith, Simone Pezzotti
Published in: Proceedings of the National Academy of Sciences, Issue 118/15, 2021, Page(s) e2023867118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2023867118

An isolated water droplet in the aqueous solution of a supramolecular tetrahedral cage

Author(s): Federico Sebastiani, Trandon A. Bender, Simone Pezzotti, Wan-Lu Li, Gerhard Schwaab, Robert G. Bergman, Kenneth N. Raymond, F. Dean Toste, Teresa Head-Gordon, Martina Havenith
Published in: Proceedings of the National Academy of Sciences, Issue 117/52, 2020, Page(s) 32954-32961, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2012545117

Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights

Author(s): Venkat Raghavan Krishnaswamy, Amit Benbenishty, Pablo Blinder, Irit Sagi
Published in: Cellular and Molecular Life Sciences, Issue 76/16, 2019, Page(s) 3229-3248, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-019-03182-6

Distinct extracellular–matrix remodeling events precede symptoms of inflammation

Author(s): Elee Shimshoni, Idan Adir, Ran Afik, Inna Solomonov, Anjana Shenoy, Miri Adler, Luca Puricelli, Fabio Sabino, Simonas Savickas, Odelia Mouhadeb, Nathan Gluck, Sigal Fishman, Lael Werner, Tomer-Meir Salame, Dror S. Shouval, Chen Varol, Ulrichauf dem Keller, Alessandro Podestàd, Tamar Geiger, Paolo Milani, Uri Alon, Irit Sagi
Published in: Matrix Biology, Issue 96, 2021, Page(s) 47-68, ISSN 0945-053X
Publisher: Elsevier BV
DOI: 10.1016/j.matbio.2020.11.001

Stripping away ion hydration shells in electrical double-layer formation: Water networks matter

Author(s): Serena R. Alfarano, Simone Pezzotti, Christopher J. Stein, Zhou Lin, Federico Sebastiani, Sarah Funke, Claudius Hoberg, Inga Kolling, Chun Yu Ma, Katja Mauelshagen, Thorsten Ockelmann, Gerhard Schwaab, Li Fu, Jean-Blaise Brubach, Pascale Roy, Martin Head-Gordon, Kristina Tschulik, Marie-Pierre Gaigeot, Martina Havenith
Published in: Proceedings of the National Academy of Sciences, Issue 118/47, 2021, Page(s) e2108568118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2108568118

Nonlinear TeraHertz Transmission by Liquid Water at 1 THz

Author(s): Fabio Novelli, Chun Yu Ma, Nidhi Adhlakha, Ellen M. Adams, Thorsten Ockelmann, Debasish Das Mahanta, Paola Di Pietro, Andrea Perucchi, Martina Havenith
Published in: Applied Sciences, Issue 10/15, 2020, Page(s) 5290, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app10155290

Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality

Author(s): Dalit Talmi-Frank, Zeev Altboum, Inna Solomonov, Yael Udi, Diego Adhemar Jaitin, Mordehay Klepfish, Eyal David, Alina Zhuravlev, Hadas Keren-Shaul, Deborah R. Winter, Irit Gat-Viks, Michal Mandelboim, Tamar Ziv, Ido Amit, Irit Sagi
Published in: Cell Host & Microbe, Issue 20/4, 2016, Page(s) 458-470, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2016.09.005

Mapping Hydration Water around Alcohol Chains by THz Calorimetry

Author(s): Fabian Böhm, Gerhard Schwaab, Martina Havenith
Published in: Angewandte Chemie International Edition, Issue 56/33, 2017, Page(s) 9981-9985, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201612162

Distinct Protein Hydration Water Species Defined by Spatially Resolved Spectra of Intermolecular Vibrations

Author(s): Viren Pattni, Tatiana Vasilevskaya, Walter Thiel, Matthias Heyden
Published in: The Journal of Physical Chemistry B, Issue 121/31, 2017, Page(s) 7431-7442, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.7b03966

Signatures of Solvation Thermodynamics in Spectra of Intermolecular Vibrations

Author(s): Rasmus A. X. Persson, Viren Pattni, Anurag Singh, Stefan M. Kast, Matthias Heyden
Published in: Journal of Chemical Theory and Computation, Issue 13/9, 2017, Page(s) 4467-4481, ISSN 1549-9618
Publisher: American Chemical Society
DOI: 10.1021/acs.jctc.7b00184

Role of Terahertz (THz) Fluctuations in the Allosteric Properties of the PDZ Domains

Author(s): Valeria Conti Nibali, Giulia Morra, Martina Havenith, Giorgio Colombo
Published in: The Journal of Physical Chemistry B, Issue 121/44, 2017, Page(s) 10200-10208, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.7b06590

Broadband terahertz pulse generation by optical rectification in GaP crystals

Author(s): Katsuyoshi Aoki, Janne Savolainen, Martina Havenith
Published in: Applied Physics Letters, Issue 110/20, 2017, Page(s) 201103, ISSN 0003-6951
Publisher: American Institute of Physics
DOI: 10.1063/1.4983371

Solvent water interactions within the active site of the membrane type I matrix metalloproteinase

Author(s): Elena Decaneto, Tatiana Vasilevskaya, Yuri Kutin, Hideaki Ogata, Moran Grossman, Irit Sagi, Martina Havenith, Wolfgang Lubitz, Walter Thiel, Nicholas Cox
Published in: Physical Chemistry Chemical Physics, Issue 19/45, 2017, Page(s) 30316-30331, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cp05572b

Integration of a rapid scanning technique into THz time-domain spectrometers for nonlinear THz spectroscopy measurements

Author(s): C. Hoberg, P. Balzerowski, M. Havenith
Published in: AIP Advances, Issue 9/3, 2019, Page(s) 035348, ISSN 2158-3226
Publisher: American Institute of Physics Inc.
DOI: 10.1063/1.5080653

LOXL2 inhibition paves the way for macrophage-mediated collagen degradation in liver fibrosis

Author(s): Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi
Published in: Frontiers in Immunology, Issue 11, 2020, Page(s) 480, ISSN 1664-3224
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.00480

Towards Intense THz Spectroscopy on Water: Characterization of Optical Rectification by GaP, OH1, and DSTMS at OPA Wavelengths

Author(s): Fabio Novelli, Biswajit Guchhait, Martina Havenith
Published in: Materials, Issue 13/6, 2020, Page(s) 1311, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma13061311

Cation enrichment in the ion atmosphere is promoted by local hydration of DNA

Author(s): Chun Yu Ma, Simone Pezzotti, Gerhard Schwaab, Magdalena Gebala, Daniel Herschlag, Martina Havenith
Published in: Physical Chemistry Chemical Physics, Issue 23, 2021, Page(s) 23203-23213, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cp01963e

The ECM path of senescence in aging: components and modifiers

Author(s): Naama Levi, Nurit Papismadov, Inna Solomonov, Irit Sagi, Valery Krizhanovsky
Published in: The FEBS Journal, Issue 287/13, 2020, Page(s) 2636-2646, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15282

MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

Author(s): Mark Owyong, Jonathan Chou, Renske JE van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard, Dalit Talmi-Frank, Inna Solomonov, Charlotte Koopman, Elin Hadler-Olsen, Mark Headley, Charlene Lin, Chih-Yang Wang, Irit Sagi, Zena Werb, Vicki Plaks
Published in: Life Science Alliance, Issue 2/6, 2019, Page(s) e201800226, ISSN 2575-1077
Publisher: Life Science Alliance LLC
DOI: 10.26508/lsa.201800226

The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS

Author(s): Jonas Ahlers, Ellen M. Adams, Verian Bader, Simone Pezzotti, Konstanze F. Winklhofer, Jörg Tatzelt, Martina Havenith
Published in: Biophysical Journal, Issue 120, 2021, Page(s) 266–1275, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2021.01.019

Spectroscopic fingerprints of cavity formation and solute insertion as a measure of hydration entropic loss and enthalpic gain

Author(s): Simone Pezzotti, Federico Sebastiani, Eliane P. van Dam, Sashary Ramos, Valeria Conti Nibali, Gerhard Schwaab, Martina Havenith
Published in: Angewandte Chemie International Edition, 2022, Page(s) e202203893, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202203893

The role of hydrophobic hydration in the free energy of chemical reactions at the gold/water interface: size and position effects

Author(s): Alessandra Serva, Martina Havenith, Simone Pezzotti
Published in: The Journal of Chemical Physics, Issue 155, 2021, Page(s) 204706, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0069498

Wrapping Up Hydrophobic Hydration: Locality Matters

Author(s): V. Conti Nibali, S. Pezzotti, F. Sebastiani, D. R. Galimberti, G. Schwaab, M. Heyden, M.-P. Gaigeot, M. Havenith
Published in: The Journal of Physical Chemistry Letters, Issue 11/12, 2020, Page(s) 4809-4816, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.1021/acs.jpclett.0c00846

Conference proceedings (1)

Designing a dielectric RF applicator cell for Terahertz transmission

Author(s): Kerstin Orend, Christoph Baer, Fabio Novelli, Dominik Welzel, Thomas Musch, Martina Havenith
Published in: 2021 International Conference on Electromagnetics in Advanced Applications (ICEAA), 2021, Page(s) 177-182
Publisher: IEEE
DOI: 10.1109/iceaa52647.2021.9539564

Other (1)

Spectral signatures of excess-proton waiting and transfer-path dynamics in aqueous hydrochloric acid solutions

Author(s): F. N. Brünig, M. Rammler, E. M. Adams, M. Havenith, R. R. Netz
Published in: arXiv [physics.chem-ph], 2022
Publisher: Cornell University
DOI: 10.48550/arxiv.2204.04334