Molecular Basis of Toxoplasma gondii Encystation and Persistence

Project Information

ToxoPersist

Grant agreement ID: 695596

DOI 10.3030/695596

Project closed

EC signature date 6 June 2016

Start date 1 October 2016

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 297 606,00

EU contribution € 2 297 606,00

Coordinated by

UNIVERSITE DE GENEVE
Switzerland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (1)

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii.

Author(s): Kloehn, Joachim; Oppenheim, Rebecca,; Siddiqui, Ghizal; de Bock, Pieter-Jan; Kumar Dogga, Sunil; Couté, Yohann; Hakimi, Mohamed-Ali; Creek, Darren,; Soldati-Favre, Dominique
Published in: BMC Biology, Issue 18(1):67, 2020
Publisher: Europe PMC
DOI: 10.1186/s12915-020-00791-7

Peer reviewed articles (14)

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii

Author(s): Lunghi M, Kloehn J, Krishnan A, Varesio E, Vadas O, Soldati-Favre D.
Published in: Nature communications, Issue vol.13, issue 1, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-27996-4

Untargeted Metabolomics Uncovers the Essential Lysine Transporter in Toxoplasma gondii

Author(s): Kloehn, Joachim; Lunghi, Matteo; Varesio, Emmanuel; Dubois, David; Soldati-Favre, Dominique
Published in: Metabolites, Issue Vol 11, Iss 476, 2021, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo11080476

Ceramide biosynthesis is critical for establishment of the intracellular niche of Toxoplasma gondii

Author(s): Mary Akinyi Nyonda, Joachim Kloehn, Piotr Sosnowski, Aarti Krishnan, Gaëlle Lentini, Bohumil Maco, Jean-Baptiste Marq, J. Thomas Hannich, Gerard Hopfgartner, Dominique Soldati-Favre,
Published in: Cell Reports, Issue Volume 40, Issue 7, 2022,, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111224

Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism

Author(s): Krishnan A, Kloehn J, Lunghi M, Chiappino-Pepe A, Waldman BS, Nicolas D, Varesio E, Hehl A, Lourido S, Hatzimanikatis V, Soldati-Favre D.
Published in: Cell Host & Microbe, Issue volume 27, issue 2, 2020, Page(s) 290-306, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.01.002

Importance of aspartyl protease 5 in the establishment of the intracellular niche during acute and chronic infection of Toxoplasma gondii

Author(s): Sunil Kumar Dogga; Matteo Lunghi; Bohumil Maco; Jiagui Li; Beatrice Claudi; Jean‐Baptiste Marq; Natalia Chicherova; Tobias Kockmann; Dirk Bumann; Adrian B. Hehl; Dominique Soldati‐Favre; Pierre‐Mehdi Hammoudi
Published in: Molecular Microbiology, Issue 118(6), 2022, Page(s) 601-622, ISSN 0950-382X
Publisher: Blackwell Publishing Inc.
DOI: 10.5167/uzh-227664

The metabolic pathways and transporters of the plastid organelle in Apicomplexa.

Author(s): Joachim Kloehn; Clément Em Lacour; Dominique Soldati-Favre
Published in: Current Opinion in Microbiology, Issue 1, 2021, Page(s) 250-258, ISSN 1369-5274
Publisher: Elsevier BV
DOI: 10.1016/j.mib.2021.07.016

Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii

Author(s): Boillat M, Hammoudi PM, Dogga SK, Pagès S, Goubran M, Rodriguez I, Soldati-Favre D.
Published in: Cell Reports, Issue 30 (2), 2020, Page(s) 320-334.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.12.019

Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis

Author(s): Pierre-Mehdi Hammoudi, Bohumil Maco, Sunil Kumar Dogga, Karine Frénal, Dominique Soldati-Favre
Published in: Molecular Microbiology, 2018, ISSN 0950-382X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/mmi.13981

Insights into the molecular basis of host behaviour manipulation by Toxoplasma gondii infection

Author(s): Pierre-Mehdi Hammoudi, Dominique Soldati-Favre
Published in: Emerging Topics in Life Sciences, Issue 1/6, 2017, Page(s) 563-572, ISSN 2397-8554
Publisher: Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
DOI: 10.1042/ETLS20170108

Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii

Author(s): Karine Frénal, Damien Jacot, Pierre-Mehdi Hammoudi, Arnault Graindorge, Bohumil Maco, Dominique Soldati-Favre
Published in: Nature Communications, Issue 8, 2017, Page(s) 15710, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15710

The roles of Centrin 2 and Dynein Light Chain 8a in apical secretory organelles discharge of Toxoplasma gondii

Author(s): Gaëlle Lentini, David J. Dubois, Bohumil Maco, Dominique Soldati‐Favre, Karine Frénal
Published in: Traffic, 2019, ISSN 1398-9219
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/tra.12673

Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets

Author(s): Matteo Lunghi; Aarti Krishnan; Dominique Soldati-Favre; Taco Kooij; Laura De Vries
Published in: Plos Pathogens, 2021, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1010124

Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii

Author(s): Nicolò Tosetti, Nicolas Dos Santos Pacheco, Eloïse Bertiaux, Bohumil Maco, Lorène Bournonville, Virginie Hamel, Paul Guichard, Dominique Soldati-Favre
Published in: eLife, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56635

Evolution, Composition, Assembly, and Function of the Conoid in Apicomplexa.

Author(s): Nicolas Dos Santos Pacheco; Nicolò Tosetti; Ludek Koreny; Ross F. Waller; Dominique Soldati-Favre
Published in: Trends in Parasitology (2020), Issue 9, 2020, Page(s) 688-704, ISSN 1471-4922
Publisher: Elsevier BV
DOI: 10.1016/j.pt.2020.05.001