An Ultra-sensitive Assay to Measure Oligomer Induced Toxicity in Human Cerebrospinal Fluid

Project Information

Neurotoxic

Grant agreement ID: 701013

DOI 10.3030/701013

Project closed

EC signature date 24 February 2016

Start date 1 August 2016

End date 31 July 2018

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 195 454,80

EU contribution € 195 454,80

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Publications

Peer reviewed articles (8)

Ultrasensitive Measurement of Ca 2+ Influx into Lipid Vesicles Induced by Protein Aggregates

Author(s): Patrick Flagmeier, Suman De, David C. Wirthensohn, Steven F. Lee, Cécile Vincke, Serge Muyldermans, Tuomas P. J. Knowles, Sonia Gandhi, Christopher M. Dobson, David Klenerman
Published in: Angewandte Chemie International Edition, Issue 56/27, 2017, Page(s) 7750-7754, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201700966

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

Author(s): Franziska Kundel, Suman De, Patrick Flagmeier, Mathew H. Horrocks, Magnus Kjaergaard, Sarah L. Shammas, Sophie E. Jackson, Christopher M. Dobson, David Klenerman
Published in: ACS Chemical Biology, 2018, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.7b01039

Inhibiting the Ca 2+ Influx Induced by Human CSF

Author(s): Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman
Published in: Cell Reports, Issue 21/11, 2017, Page(s) 3310-3316, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.11.057

Optical structural analysis of individual α-synuclein oligomers

Author(s): Juan Alberto Varela, Margarida Rodrigues, Suman De, Patrick Flagmeier, Sonia Gandhi, Christopher M. Dobson, David Klenerman, Steven Lee
Published in: Angewandte Chemie International Edition, 2018, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201710779

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

Author(s): Daniel R. Whiten, Dezerae Cox, Mathew H. Horrocks, Christopher G. Taylor, Suman De, Patrick Flagmeier, Laura Tosatto, Janet R. Kumita, Heath Ecroyd, Christopher M. Dobson, David Klenerman, Mark R. Wilson
Published in: Cell Reports, Issue 23/12, 2018, Page(s) 3492-3500, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.05.074

Quantifying Co-Oligomer Formation by α-Synuclein

Author(s): Marija Iljina, Alexander J. Dear, Gonzalo A. Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R. Whiten, Thomas C. T. Michaels, Daan Frenkel, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman
Published in: ACS Nano, 2018, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b03575

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

Author(s): Daniel R. Whiten, Yukun Zuo, Laura Calo, Minee-Liane Choi, Suman De, Patrick Flagmeier, David C. Wirthensohn, Franziska Kundel, Rohan T. Ranasinghe, Santiago E. Sanchez, Dilan Athauda, Steven F. Lee, Christopher M. Dobson, Sonia Gandhi, Maria-Grazia Spillantini, David Klenerman, Mathew H. Horrocks
Published in: ChemBioChem, Issue 19/19, 2018, Page(s) 2033-2038, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800209

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

Author(s): Ji-Eun Lee, Jason C. Sang, Margarida Rodrigues, Alexander R. Carr, Mathew H. Horrocks, Suman De, Marie N. Bongiovanni, Patrick Flagmeier, Christopher M. Dobson, David J. Wales, Steven F. Lee, David Klenerman
Published in: Nano Letters, 2018, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.8b02916