An Ultra-sensitive Assay to Measure Oligomer Induced Toxicity in Human Cerebrospinal Fluid

Información del proyecto

Neurotoxic

Identificador del acuerdo de subvención: 701013

DOI 10.3030/701013

Proyecto cerrado

Fecha de la firma de la CE 24 Febrero 2016

Fecha de inicio 1 Agosto 2016

Fecha de finalización 31 Julio 2018

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total € 195 454,80

Aportación de la UE € 195 454,80

Coordinado por

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Publicaciones

Peer reviewed articles (8)

Ultrasensitive Measurement of Ca 2+ Influx into Lipid Vesicles Induced by Protein Aggregates

Autores: Patrick Flagmeier, Suman De, David C. Wirthensohn, Steven F. Lee, Cécile Vincke, Serge Muyldermans, Tuomas P. J. Knowles, Sonia Gandhi, Christopher M. Dobson, David Klenerman
Publicado en: Angewandte Chemie International Edition, Edición 56/27, 2017, Página(s) 7750-7754, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201700966

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

Autores: Franziska Kundel, Suman De, Patrick Flagmeier, Mathew H. Horrocks, Magnus Kjaergaard, Sarah L. Shammas, Sophie E. Jackson, Christopher M. Dobson, David Klenerman
Publicado en: ACS Chemical Biology, 2018, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.7b01039

Inhibiting the Ca 2+ Influx Induced by Human CSF

Autores: Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman
Publicado en: Cell Reports, Edición 21/11, 2017, Página(s) 3310-3316, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.11.057

Optical structural analysis of individual α-synuclein oligomers

Autores: Juan Alberto Varela, Margarida Rodrigues, Suman De, Patrick Flagmeier, Sonia Gandhi, Christopher M. Dobson, David Klenerman, Steven Lee
Publicado en: Angewandte Chemie International Edition, 2018, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201710779

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

Autores: Daniel R. Whiten, Dezerae Cox, Mathew H. Horrocks, Christopher G. Taylor, Suman De, Patrick Flagmeier, Laura Tosatto, Janet R. Kumita, Heath Ecroyd, Christopher M. Dobson, David Klenerman, Mark R. Wilson
Publicado en: Cell Reports, Edición 23/12, 2018, Página(s) 3492-3500, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.05.074

Quantifying Co-Oligomer Formation by α-Synuclein

Autores: Marija Iljina, Alexander J. Dear, Gonzalo A. Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R. Whiten, Thomas C. T. Michaels, Daan Frenkel, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman
Publicado en: ACS Nano, 2018, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.8b03575

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

Autores: Daniel R. Whiten, Yukun Zuo, Laura Calo, Minee-Liane Choi, Suman De, Patrick Flagmeier, David C. Wirthensohn, Franziska Kundel, Rohan T. Ranasinghe, Santiago E. Sanchez, Dilan Athauda, Steven F. Lee, Christopher M. Dobson, Sonia Gandhi, Maria-Grazia Spillantini, David Klenerman, Mathew H. Horrocks
Publicado en: ChemBioChem, Edición 19/19, 2018, Página(s) 2033-2038, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800209

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

Autores: Ji-Eun Lee, Jason C. Sang, Margarida Rodrigues, Alexander R. Carr, Mathew H. Horrocks, Suman De, Marie N. Bongiovanni, Patrick Flagmeier, Christopher M. Dobson, David J. Wales, Steven F. Lee, David Klenerman
Publicado en: Nano Letters, 2018, ISSN 1530-6984
Editor: American Chemical Society
DOI: 10.1021/acs.nanolett.8b02916