Objective
Objectives: There is an unabated rise in the burden of type 2 diabetes (T2D) with associated premature morbidity, mortality and cost to individuals and society. There is an urgent need to identify modifiable factors that can prevent T2D. This Fellowship aims to use objectively measured nutritional biomarkers to improve the precision of dietary assessment for investigating the association between dietary factors and T2D risk. The use of biomarkers opens the possibility to investigate gene/diet interactions, which can lay the foundation for future stratified or personalised nutrition, and to address causality of associations using genetic-based approaches.
Method: Measurement of plasma vitamin C, six carotenoids and 25-hydroxyvitamin D is now complete in the EPIC-InterAct study across 26 centres within 8 European countries in the world’s largest study of T2D incidence with 12,403 new-onset T2D cases, and a random sub-cohort of 16,835 individuals. We will examine the distribution and determinants of these nutritional biomarkers within European populations and investigate the association between biomarkers and T2D, and biomarker-gene interaction on T2D. Combining these data with other studies, we will use Mendelian randomisation to examine potential causal association of biomarkers with T2D.
Relevance: Diet and nutrition are crucial for the prevention of non-communicable disease including T2D, but measurement error in self-report dietary assessment has posed a major challenge in identifying specific dietary components that elevate or mitigate disease risk. The systematic use of nutritional biomarkers on an unprecedented scale opens up an important new frontier to advance diet/health research. Specifically, this proposal will clarify the distribution and determinants of important biomarkers within European populations and as well as increasing aetiological understanding, will enable the estimation of the population impact of dietary factors on avoiding new cases of T2D
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences health sciences public health epidemiology
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences health sciences nutrition
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.