Objective
There is an urgent need for new vaccines, but avoiding side effects is crucial for patient compliance. To address this, new generation vaccines with safe, but weakly immunogenic antigens are formulated with carriers and adjuvants to induce the desired immunological response. Inorganic nanoparticles (NP) have shown potential as carriers while immune stimulators of microbial origin are proven to ensure long lasting immune response. Their successful integration into nanovaccines requires thorough analysis of the inorganic/organic interface. Solution state NMR spectroscopy has recently been established as a potent characterisation tool towards this end.
My objective is twofold: I intend to elaborate new vaccine-carrier nanosystems and to develop NMR spectroscopic surface characterization methods for their analysis that may be generalized for application to other NPs.
I will use my expertise in preparative colloid chemistry to tailor series of new ZrO2- and hydroxyapatite-based NPs of varied size. For their characterisation I will be trained to carry out solution NMR measurements from the toolbox developed by the Host. The outcome will be invaluable for guiding the surface modification of these NPs to obtain vaccine carriers. The project also aims at the further development of NMR methodology. The potential of solid state NMR measurements in this respect will be explored as a secondment. Another secondment is devoted to the early study of in vitro stability, fate and toxicity of the new carriers.
The planned research will train me in a cutting-edge analysis technique, and by that means provide me more independence in my work. Furthermore, it will establish an interdisciplinary cooperation between Partner Institutes. The results and the planned outreach activities are also expected to have a positive impact on EU: these new characterization tools would be useful for food, cosmetic and nanomedicine industries and may contribute to improved customer and patient safety.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology nanomedicine
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
- medical and health sciences basic medicine immunology immunotherapy
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9000 GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.