Objective
Cold atmospheric plasma (CAP) has shown promise in minimally invasive surgery by selectively treating cancerous cells with little or no damage to healthy cells. The selective destruction of cancerous cells can be used to aid and enhance current cancer treatments and can also be the cure for forms of inoperable cancer. The selective treatment can be obtained by using the plasma to induce cell apoptosis, in which the cell self-destructs in a tightly controlled way without causing inflammation in the surrounding tissue. One of the major challenges of this research is that the exact mechanism of plasma induced apoptosis is not well understood. The fellow proposes to test the hypothesis CAP builds up electric fields across the cell membrane that cause electroporation for the cancerous but not the healthy cell because they have different electrical and physical properties. Electroporation allows for the penetration of reactive oxygen species (ROS) into the cancerous cell causing apoptosis while leaving the healthy cells intact. The fellow will develop numerical simulations to allow the study of cell surface electric fields and generation of ROS will explore the parameter space in which the electroporation and therefore apoptosis will be induced only for the cancerous cells. During his secondment the Fellow will perform experiments by applying CAP onto two Breast cell lines: MDA-MB-231 (cancerous) MCF-12F (healthy) and will use flow cytometry to measure electroporation and apoptosis. The results of this research will elucidate how CAP interacts with tissue and under what conditions it causes apoptosis. This will allow us to get closer to an actual medical device utilizing CAP to treat cancer on patients. The fellow will gain scientific skills in cell culture handling, storing, preparation, plasma sources and characterization and complementary skills and will reach a position of professional maturity and leadership in research and development in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry noble gases
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences optics laser physics
- natural sciences chemical sciences electrochemistry bioelectrochemistry electroporation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1678 Nicosia
Cyprus
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.