Objective
As the world population continues to grow and a shortage of protein supply is foreseen, there is a need to identify new and sustainable protein sources. While these alternative proteins must be of high nutritional quality, they also need to be safe for consumption. Dietary proteins and their digestion products can influence a number of regulatory systems, including the immune system. By interacting with elements of the immune system, proteins can help balance and stabilize immune responses, but may also trigger adverse effects such as allergic reactions. While the effects of proteins and peptides on the adaptive immunity have been examined in a number of studies, few have studied how these molecules are absorbed through the small intestine and interact with the innate immune system. Since, in order to trigger an immune response proteins must first be transported across the intestinal wall and interact with the innate immune system, understanding these processes is key to determining the immunological effects of protein consumption. The aim of the proposed project is to develop an in vitro model to evaluate the impact of dietary proteins on the immune system. This research will first examine the uptake of proteins and their digests across the intestinal wall using cellular models mimicking the intestinal epithelium and subsequently investigate the effect of the absorbed proteins/peptides on the immune system’s key players, including the dendritic and T cells. The model system that this research aims to develop could help shed light on the roles played by dietary proteins in regulating intestinal immunity and serve as a tool to evaluate the immunological properties of novel and sustainable proteins. Thus, this research is of relevance not only to the European food industry, but also to public health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences nutrition
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6708 PB Wageningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.