Objective
For animals and humans to be successful in their environments, their motor and cognitive behavior must be adjusted to the constantly changing reality at a millisecond-timescale. For example, it is fairly simple for a brain to determine which muscles need to be activated to catch a falling object, but much harder to determine when and for how long. Without correct timing of the executive brain functions, as happens in some neurological disorders, the individual is unable to produce smooth and accurate movements and will also have difficulties with a range of cognitive functions requiring orchestration of distinct mental operations. The tripartite olivo-cerebellar system (OCS), which is formed by the inferior olive (IO), cerebellar cortex
(CCTX) and cerebellar nuclei (CN), is considered critical for generating proper timing for many motor and cognitive operations. Interestingly, all three areas, IO, CTX and CN, have intrinsic oscillatory properties and together they constitute a reverberating microcircuit, beating with well-timed responses to requests from the sensorimotor system. The ultimate timing of the output of this system, by which it imposes its effects upon the rest of the brain, is mediated by the CN. Indeed, decades of research on the OCS has resulted in detailed concepts as to how it may generate and control computations with high temporal complexity. However, due to methodological difficulties the function of the nucleo-olivary (NO) pathway, which links the CN with the IO, has been neglected, hindering completion of the cerebellar theory. To crack the relevant temporal
codes of this loop I have developed specific viral optogenetic tools that allow for targeted control of the NO pathway. Using them I will define the NO interactions that take place during behavior and learning, and examine how these interactions are perturbed in neurological disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology cognitive neuroscience
- natural sciences physical sciences optics microscopy confocal microscopy
- medical and health sciences basic medicine neurology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3015 GD Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.