Objective "In this Marie Skłodowska-Curie Fellowship project entitled “Multi-SIP Hydrogel” I will design a modular synthetic platform for preparing multifunctional self-immolative polymer (SIP) hydrogels designed to accelerate tissue regeneration in chronic skin wounds. The hydrogels will contain multiple SIP components, each designed to rapidly degrade and deliver a therapeutic payload in response to a specific biochemical stimulus typical of a chronic wound (e.g. reactive oxygen species or enzymatic action). During the two years of this Fellowship, I aim to establish a proof-of-principle SIP-hydrogel system that will undergo sequential stimuli-responsive degradation and promote cell proliferation in vitro. This Fellowship will be undertaken under the supervision of Prof. Molly Stevens in the Division of Biomaterials and Regenerative Medicine at the Karolinska Institute (KI), which has the world-leading expertise in polymer chemistry, biomaterials engineering, cell biology and tissue engineering crucial to the objectives of the proposed work plan. Due to the modular design of the ""Multi-SIP Hydrogel"" platform, there is broad scope for designing SIP-hydrogels matched to different tissue types once a proof-of-principle is established. This will initiate new research areas at the cutting edge of biomaterials science, which will help me to establish my own independent research career following the proposed Fellowship." Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesclinical medicineendocrinologydiabetesnatural scienceschemical sciencespolymer sciencesmedical and health scienceshealth sciencesnutritionobesity Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2015 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator KAROLINSKA INSTITUTET Net EU contribution € 173 857,20 Address Nobels Vag 5 17177 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 173 857,20
