Objective
Oxidative damage to DNA is of considerable interest because of the key role-played by oxidation in aging, mutagenesis and carcinogenesis. The aim of this project is to help understanding the mechanisms of photooxidation of DNA induced in biological system s by various exo- and/or endogenous photosensitizers.
The experiments will involve the synthesis and photochemical studies of a range of DNA oligonucleotides of specially designed sequences, containing suitable photosenisitizers, namely fluorescent acridi nium or pyridinium cation derivatives as electron acceptors, and guanine residues, as electron donors, at defined positions. Techniques used include solid phase DNA synthesis, photoirradiation, laser flash photolysis, steady-state and time-resolved fluorimetry, high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences physical chemistry photochemistry
- natural sciences physical sciences optics microscopy fluorescence lifetime imaging
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
POZNAN
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.