Periodic Reporting for period 1 - CHERI (Chromatin targeting and remodelling by bacterial effectors in plant immunity)
Reporting period: 2016-04-01 to 2018-03-31
By establishing, designing and using innovative experiment, the project has led to a better understanding of how an immuno-receptor complex can be targeted by a bacterial effector and might modify its conformation at the chromatin level. Exciting data generated by objective 4 have brought new insights about a bacterial effector molecular function and virulence activity never suspected before. This project opens new research guidelines that could be easily followed up within a PhD thesis or postdoc project and lead to high quality scientific outputs and publications.
In animals, pathogen-triggered chromatin remodeling is well documented and considered as a very promising area for future research on infectious diseases. However, to date plant pathogen-triggered chromatin remodeling has received very little attention. The CHERI project working model offers the opportunity to evaluate the importance of this process in the plant responses to different pathogens.