Objective
The human gut hosts a large and diverse ecosystem of microbes termed the gut microbiome.
Microbiome imbalances, often affecting the interplay of the microbes with the host immune system, have been linked to a variety of diseases. Being amenable for modulation, for example via diet and probiotics, the gut microbiome is a potential target of high interest for promoting human well-being.
Since the proportion of Europeans above 65 is expected to double from 2010 to 2050, healthy aging is an important issue on the European policy agenda. Aging has been linked to an enhanced pro-inflammatory status, and many age-associated diseases involve inflammation.
Changes in the taxonomic composition of the gut microbiome with age that associate with increased frailty among the elderly have been described. However, the evidence is still limited and possible interventions remain to be explored. Moreover, changes in the pro-inflammatory potential of gut microbes can occur without coinciding compositional changes of the microbiome.
To address these issues, we propose an approach combining high-throughput sequencing, immunoglobulin A-based cell sorting, microscopy, and bioinformatics to explore differences in the composition and pro-inflammatory potential of the gut microbiome of young and older Danish individuals.
Using mouse as model system, we will further explore whether a periodic fasting scheme with established metabolic health benefits when applied from middle to old age promotes gut microbiome modulations.
The project will be supervised by associate professor Manimozhiyan Arumugam at the Center for Basic Metabolic Research (CBMR, University of Copenhagen). CBMR excels in research on the impact of the gut microbiome on metabolic and inflammatory disorders. This environment of expertise as well as access to human microbiome samples with associated information on health status will be a key asset to this project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences nutrition
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- natural sciences biological sciences microbiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.