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Iridium Catalyzed Reductive Cyclization Cascades

Objective

The aim of this fellowship is to develop new reductive cyclization cascades of lactams and amides that establish these feedstock chemicals as important chemical precursors to reactive iminium ions which can be intercepted by pendant nucleophiles and exploited in carbon-carbon bond formation. A range of indole nucleophiles linked to amide and lactam functionality will be investigated for performance in the iridium catalyzed reductive cyclization cascades, and, based on successful proof of concept studies already performed in the Dixon group, a range of semi-saturated nitrogen-containing polycyclic structures possessing one or more stereocentres distributed over an architecturally complex framework should result. As well as studying diastereocontrol in the cascades, catalytic enantioselective variants will also be investigated. Finally, the application of the indole (spiro)cyclization reaction to the total synthesis of aspidospermidine will showcase the utility of the developed chemistry. This multidisciplinary Fellowship, based on high-quality and novel research at the University of Oxford, one of the top-research centres worldwide, will complement Dr Xie’s skills and knowledge to improve his career possibilities and at the same time, Dr Xie’s experience in creating catalytically active transition metal complexes will be critical for developing chiral versions of the iridium catalyst during the development of a catalytic asymmetric version of the reductive cyclization cascade.

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 195 454,80
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00