The genetic basis for glial differentiation in the developing zebrafish retina.

Informations projet

Glial Patterning

N° de convention de subvention: 707668

DOI 10.3030/707668

Projet clôturé

Date de signature de la CE 24 Février 2016

Date de début 1 Mars 2016

Date de fin 28 Février 2018

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 195 454,80

Contribution de l’UE € 195 454,80

Coordonné par

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Royaume-Uni

Objectif

Glia far out number neurons in the brain and their defects are now known to be associated with many neurological diseases. Glial specification and physiological function are very well studied however, remarkably little is known about they way in which glia are positioned or shaped in order to perform their critical support functions. The goal of the present study is to broaden the field of glial development by using new techniques to ask previously unattainable questions. This central goal of this research project is carried out through an in-depth morphological, genetic and transcritpomic analyses of differentiating Müller Glia in the Zebrafish (Danio rerio) eye. Results from these studies will provide and the first extensive profiling of a differentiating glial population. Furthermore, the extensive data that will be generated in this proposal will provide a basis for many future studies on glial biology for both in the host laboratory and for the experienced researcher during his career development. Ultimately, these and future studies will provide a foundation for identifying the molecular networks that underlie glial patterning in the brain that will no doubt be informative in the study of glial related neurological disease.

Champ scientifique (EuroSciVoc)

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• sciences naturelles › sciences biologiques › neurobiologie
• sciences naturelles › sciences biologiques › génétique
• sciences médicales et de la santé › médecine clinique › ophtalmologie
• sciences médicales et de la santé › médecine fondamentale › physiologie
• sciences médicales et de la santé › médecine clinique › psychiatrie › schizophrénie

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Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thème(s)

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Appel à propositions

H2020-MSCA-IF-2015

Régime de financement

MSCA-IF-EF-ST -

Coordinateur

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• Contribution nette de l'UE: € 195 454,80
• Adresse: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; Royaume-Uni
• Région: East of England › East Anglia › Cambridgeshire CC
• Type d’activité: Établissements d’enseignement supérieur ou secondaire
• Coût total: € 195 454,80