Objective Ebolaviruses comprise five virus species of which at least three are highly pathogenic for humans. Other mammalian species such as non-human primates, forest antelopes and pigs are susceptible to ebolavirus infection with different degree of severity. However, bats and laboratory mice are entirely resistant to ebolaviruses. Why do ebolaviruses cause severe disease in some species but not others? This question, which is paramount to understand ebolavirus pathogenesis is the central question of our proposal. To address it, we will build on technology developed by the host laboratory to develop xenochimeric mice, that is, severely immunodeficient mice whose hematopoietic system has been replaced with another from a donor species (e. g. bats, monkeys or humans). This novel in vivo system will allow us to investigate the kinetics of ebolavirus infection across species and to dissect the mechanisms responsible for pathogenicity. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinephysiologypathophysiologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesebolamedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2015 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Net EU contribution € 71 442,00 Address Bernhard nocht strasse 74 20359 Hamburg Germany See on map Region Hamburg Hamburg Hamburg Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all LEIBNIZ-INSTITUT FUR VIROLOGIE Participation ended Germany Net EU contribution € 100 018,80 Address Martinistrasse 52 20251 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
