Obiettivo Ebolaviruses comprise five virus species of which at least three are highly pathogenic for humans. Other mammalian species such as non-human primates, forest antelopes and pigs are susceptible to ebolavirus infection with different degree of severity. However, bats and laboratory mice are entirely resistant to ebolaviruses. Why do ebolaviruses cause severe disease in some species but not others? This question, which is paramount to understand ebolavirus pathogenesis is the central question of our proposal. To address it, we will build on technology developed by the host laboratory to develop xenochimeric mice, that is, severely immunodeficient mice whose hematopoietic system has been replaced with another from a donor species (e. g. bats, monkeys or humans). This novel in vivo system will allow us to investigate the kinetics of ebolavirus infection across species and to dissect the mechanisms responsible for pathogenicity. Campo scientifico natural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinephysiologypathophysiologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesebolamedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2015 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Contribution nette de l'UE € 71 442,00 Indirizzo BERNHARD NOCHT STRASSE 74 20359 Hamburg Germania Mostra sulla mappa Regione Hamburg Hamburg Hamburg Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 71 442,00 Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto LEIBNIZ-INSTITUT FUR VIROLOGIE Partecipazione conclusa Germania Contribution nette de l'UE € 100 018,80 Indirizzo MARTINISTRASSE 52 20251 Hamburg Mostra sulla mappa Regione Hamburg Hamburg Hamburg Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 100 018,80